Targeting Th17 cells in autoimmune diseases.
Cambridge, United States. In Trends Pharmacol Sci, 14 Sep 2014
Given that Th17 cells express IL-17 together with many other proinflammatory cytokines [IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor (GM-CSF)], targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.
Interleukin-17 in human inflammatory diseases.
Tehrān, Iran. In Postepy Dermatol Alergol, Aug 2014
Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F.
Role of TH17 cytokines in the control of colorectal cancer.
Roma, Italy. In Oncoimmunology, Jan 2014
Studies with murine models of CRC have delineated the mechanisms by which TH17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs.
Anticytokine autoantibody-associated immunodeficiency.
Bethesda, United States. In Annu Rev Immunol, Dec 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
[Role of Th17 lymphocytes in pathogenesis of colorectal cancer].
In Postepy Hig Med Dosw (online), Dec 2013
Th17 lymphocytes produce a number of pro-inflammatory cytokines, such as interleukin (IL)-17A, IL-17F, IL-21, IL-22 and tumor necrosis factor (TNF)-a, and play a key role in mucosal defense against various pathogens.