GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 17F
mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
mL-1
Electrochemically assisted sorption on oxidized multiwalled carbon nanotubes for preconcentration of Cr, Mn, Co, Ni, Cu and Zn from water samples.
New
Katowice, Poland. In Analyst, 11 Apr 2013
If measurements are performed using the EDXRF spectrometer, the detection limits are 1 ng mL-1, 5 ng mL-1, 5 ng mL-1, 7 ng mL-1, 1 ng mL-1, 8 ng mL-1 for Cr(iii), Mn(ii), Co(ii), Ni(ii), Cu(ii) and Zn(ii), respectively.
New water-soluble polypyridine silver(i) derivatives of 1,3,5-triaza-7-phosphaadamantane (PTA) with significant antimicrobial and antiproliferative activities.
New
Wrocław, Poland. In Dalton Trans, 11 Apr 2013
Apart from representing the first examples of the metal-PTA derivatives bearing polypyridine ligands, also feature solubility in water (S25°C ≈ 4-18 mg mL-1).
Fabrication of a bowl-shaped silver cavity substrate for SERS-based immunoassay.
New
Suzhou, China. In Analyst, 11 Apr 2013
The labeled protein can be detected over a wide concentration range and the detection limit of TRITC and Atto610 labeled proteins were 50 and 5 pg mL-1, respectively.
Combination of solid phase extraction and surface-enhanced Raman spectroscopy for rapid analysis.
New
Jinan, China. In Analyst, 11 Apr 2013
As an example, the quantitative analysis of fluoranthene was accomplished in the concentration range of 0.01-100 μg mL-1 with this column.
An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.
New
Coimbra, Portugal. In Analyst, 08 Apr 2013
Calibration curves of both analytes were linear (r2 ≥ 0.997) in the concentration range of 25-3000 ng mL-1 and their limits of quantification were established to be 25 ng mL-1.
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.
New
Impact
Innsbruck, Austria. In Immunity, 24 Feb 2013
Consistently, Prkca(-/-) cells failed to mount appropriate IL-17A, but not IL-17F, responses in vitro and were resistant to induction of Th17-cell-dependent experimental autoimmune encephalomyelitis in vivo.
Emerging treatment for chronic migraine and refractory chronic migraine.
Review
New
Roma, Italy. In Expert Opin Emerg Drugs, Sep 2012
AREAS COVERED: State-of-the-art and future medical treatments of chronic migraine include: OnabotulinumtoxinA, antiepileptic drugs (Levetiracetam, Magnesium valproate hydrate, Lacosamide, BGG-492), 5-HT agonists (Lasmiditan, NXN-188, novel delivery systems of Sumatriptan, a well-established drug treatment for acute migraine), CGRP receptor antagonists (BMS-927711), ML-1 agonists (Ramelteon), orexin receptor antagonist (MK-6096), plant-derived compound (LLL-2011) and other multitarget drugs such as Tezampanel, Tonabersat, intranasal carbon dioxide and BOL-148.
Immunity to infection in IL-17-deficient mice and humans.
Review
New
New York City, United States. In Eur J Immunol, Sep 2012
In humans, the study of patients with various primary immunodeficiencies, including autosomal dominant hyper-IgE syndrome caused by dominant-negative STAT3 mutations and autosomal recessive autoimmune polyendocrinopathy syndrome type 1 caused by null mutations in AIRE, has suggested that IL-17A, IL-17F and/or IL-22 are essential for mucocutaneous immunity to Candida albicans.
Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies.
Review
New
Paris, France. In Am J Pathol, Jul 2012
Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4(+) T cells.
TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection.
Review
New
Zürich, Switzerland. In J Allergy Clin Immunol, Jun 2012
T(H)17 and T(H)22 cells are 2 emerging T(H) cell subsets that link the immune response to tissue inflammation; IL-17A and IL-17F and IL-22 are their respective prototype cytokines.
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
New
Impact
San Francisco, United States. In Nat Med, Apr 2012
Interleukin-17A (IL-17A), but not IL-17F or IL-22, enhanced contractile force generation of airway smooth muscle through an IL-17 receptor A (IL-17RA)-IL-17RC, nuclear factor κ light-chain enhancer of activated B cells (NF-κB)-ras homolog gene family, member A (RhoA)-Rho-associated coiled-coil containing protein kinase 2 (ROCK2) signaling cascade.
[Do Th17 cells play an important role in the pathogenesis and prognosis of ovarian cancer?].
Review
New
In Ginekol Pol, Apr 2012
Produce IL-17A, IL-17F, IL-21, IL-22, IL-26, IL-6, TNF-alpha.
Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.
New
Impact
Houston, United States. In Immunity, Feb 2012
T helper 17 (Th17) cells specifically transcribe the Il17 and Il17f genes, which are localized in the same chromosome region, but the underlying mechanism is unclear.
Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax.
GeneRIF
France. In Infect Immun, 2012
This work demonstrates the important roles of both IL-17 signaling and neutrophils in clearing this pathogen and surviving pulmonary Bacillus anthracis infection.
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Impact
San Francisco, United States. In Nat Immunol, 2011
IL-17C stimulated epithelial inflammatory responses, including the expression of proinflammatory cytokines, chemokines and antimicrobial peptides, which were similar to those induced by IL-17A and IL-17F.
IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice.
GeneRIF
New Haven, United States. In Biochem Biophys Res Commun, 2011
these results suggest the proinflammatory and essential role of IL-17F to develop spontaneous intestinal tumorigenesis in Apc(Min/+) mice in the presence of IL-17A.
Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia.
GeneRIF
Maebashi, Japan. In Eur J Haematol, 2011
IL-17F 7488 T allele is significantly associated with the development of chronic ITP, suggesting a role for IL-17F in the pathogenesis of chronic immune thrombocytopenia.
The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
GeneRIF
Haifa, Israel. In Eur J Immunol, 2011
Data show that Mel-18 and Ezh2 positively regulate the expression of Il17a and Il17f.
Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis.
GeneRIF
Tokyo, Japan. In Fertil Steril, 2011
These findings suggest that IL-17F may stimulate the development of endometriosis by up-regulation of IL-8 and COX2.
CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model.
Impact
Bethesda, United States. In Immunity, 2011
Here we explore why under Th17 cell polarizing conditions, Treg cells did not suppress, but rather upregulated, the expression of interleukin-17A (IL-17A), IL-17F, and IL-22 from responding CD4(+) T cells (Tresp cells).
