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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Interleukin 17F

mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, IL-21, CAN, Interleukin-6, HAD
Papers on mL-1
Self-Enhanced Electrochemiluminescence Nanorods of Tris(bipyridine) Ruthenium (II) Derivative and Its Sensing Application for detection of N-acetyl-β-D-glucosaminidase.
New
Yuan et al., In Anal Chem, Feb 2016
Based on sandwiched immunoreactions, a simple and sensitive "signal-on" immunosensor is constructed for the detection of N-acetyl-β-D-glucosaminidase (NAG), a biomarker of diabetic nephropathy, with excellent linear in concentrations varying from 1 ng mL-1 to 0.5 pg mL-1 and a detection limit of 0.17 pg mL-1.
Cytotoxicityof Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity.
New
Hwu et al., Taiwan. In Chemistry, Feb 2016
Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 is with higher cytotoxicity of ~30 g mL-1.
Proinflammatory T cells and IL-17 stimulate osteoblast differentiation.
New
Alblas et al., Utrecht, Netherlands. In Bone, Feb 2016
IL-17 A and IL-17F, their main proinflammatory cytokines, similarly exhibited strong osteogenic effects when exposed directly to MSCs.
[Abnormal expression of IL- 23/IL- 17 axis in peripheral blood of 45 patients with primary immune thrombocytopenia].
New
Wu et al., Suzhou, China. In Zhonghua Xue Ye Xue Za Zhi, Jan 2016
METHODS: The real-time quantitative reverse transcription-polymerase chain reaction(RT-PCR)was used to determine the expression of IL-23p19, p40, p35, IL-23R, IL-12Rβ1, IL-12Rβ2, IL-17A, IL-17F mRNA in the peripheral blood of 45 ITP patients and 30 healthy controls.
IL-17 polymorphisms and asthma risk: a meta-analysis of 11 single nucleotide polymorphisms.
Review
New
Li et al., Ningbo, China. In J Asthma, Dec 2015
OBJECTIVE: There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time.
IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies.
Review
New
Bissonnette et al., Portland, United States. In J Invest Dermatol, Aug 2015
Generally, downstream deficiencies (e.g., IL-17A, IL-17F) are associated with fewer disorders compared with upstream deficiencies, suggesting that selectively blocking downstream targets may result in a narrower range of side effects.
Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.
Review
New
Dumitraşcu et al., Cluj-Napoca / Kolozsvár, Romania. In World J Gastroenterol, Jun 2015
An efficient strategy for IBD therapy is represented by the combination of IL-17A and IL-17F in acute IL-17A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17F knockout, DSS-induced colitis have been observed.
Role of IL-25 in Immunity.
Review
New
Parizad et al., Īlām, Iran. In J Clin Diagn Res, Apr 2015
Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
New
Impact
Dixit et al., San Francisco, United States. In Nature, Mar 2015
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases.
Association of interleukin-17 gene polymorphisms and Helicobacter pylori infection with gastric cancer susceptibility: a cumulative and comprehensive meta-analysis.
Hu et al., Shiyan, China. In Int J Clin Exp Med, 2014
METHODS: PubMed, Embase, CNKI and Wanfang databases were researched on the associations between IL-17A rs2275913G>A, rs3748067C>T and IL-17F rs763780 T>C and gastric cancer risk.
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
Impact
Xu et al., Ann Arbor, United States. In Nat Med, 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
Anticytokine autoantibody-associated immunodeficiency.
Review
Impact
Browne, Bethesda, United States. In Annu Rev Immunol, 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Impact
Casanova et al., New York City, United States. In Immunity, 2013
Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic mucocutaneous candidiasis (CMC).
IL-17 cytokines in immunity and inflammation.
Review
Dong et al., Beijing, China. In Emerg Microbes Infect, 2013
Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology.
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Impact
Rawlings et al., Córdoba, Argentina. In Nat Immunol, 2013
With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
GeneRIF
Fuke et al., Hachiōji, Japan. In Gene, 2012
IL17F gene polymorphism 7488T>C influences bone mineral density.
Interleukin-33 induces interleukin-17F in bronchial epithelial cells.
GeneRIF
Hizawa et al., Tsukuba, Japan. In Allergy, 2012
data suggest that the IL-33/IL-17F axis is involved in allergic airway inflammation
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer.
GeneRIF
Pang et al., Harbin, China. In Plos One, 2011
Results suggested that single-nucleotide polymorphisms (SNPs) in IL-17A but not IL-17F were associated with the risk of breast cancer.
A protective role by interleukin-17F in colon tumorigenesis.
GeneRIF
Dong et al., Wuhan, China. In Plos One, 2011
Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis
[Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease].
GeneRIF
Efremov et al., In Eksp Klin Gastroenterol, 2010
Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease
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