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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Sep 2015.

Interleukin 17F

mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, IL-21, CAN, Interleukin-6, HAD
Papers on mL-1
Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients.
New
Li et al., Jinan, China. In Neurol Sci, 04 Oct 2015
UNASSIGNED: Alleles of IL-17A and IL-17F genes were reported to be associated with many inflammatory and autoimmune disorders in Asian patients.
Dietary Vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium induced colitis.
New
Vallance et al., Colombia. In Am J Physiol Gastrointest Liver Physiol, 03 Oct 2015
Intestinal tissues of infected vitamin D3 deficient mice displayed increased inflammatory cell infiltrates as well as significantly higher gene transcript levels of inflammatory mediators TNF-α, IL-1β, IL-6, TGF-β, IL-17A and IL-17F as well as the antimicrobial peptide REG3γ.
Investigating the Occurrence and Environmental Significance of Methylated Arsenic Species in Atmospheric Particles by Overcoming Analytical Method Limitations.
New
Stephanou et al., In Environ Sci Technol, 03 Oct 2015
In the present study an HPLC (with an anion and cation exchange column connected in sereis)-arsine generation-ICP-MS system provided complete separation of all five As species and limits of detection from 10 to 25 pg As mL-1.
Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis.
New
Ramesh et al., Augusta, United States. In J Am Soc Nephrol, 02 Oct 2015
Protective effects were also observed after administration of IL-17F but not IL-17C or IL-17E.
Association between Th17-related cytokines and risk of non-small cell lung cancer among patients with or without chronic obstructive pulmonary disease.
New
Bai et al., Chongqing, China. In Cancer, 01 Oct 2015
Circulating levels of Th17-related cytokines, including interleukin (IL) 23 (IL-23), IL-17A, IL-17F, IL-22, and tumor necrosis factor-α, were measured.
IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies.
Review
New
Bissonnette et al., Portland, United States. In J Invest Dermatol, 31 Aug 2015
Generally, downstream deficiencies (e.g., IL-17A, IL-17F) are associated with fewer disorders compared with upstream deficiencies, suggesting that selectively blocking downstream targets may result in a narrower range of side effects.
Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.
Review
New
Dumitraşcu et al., Cluj-Napoca / Kolozsvár, Romania. In World J Gastroenterol, Jun 2015
An efficient strategy for IBD therapy is represented by the combination of IL-17A and IL-17F in acute IL-17A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17F knockout, DSS-induced colitis have been observed.
Role of IL-25 in Immunity.
Review
New
Parizad et al., Īlām, Iran. In J Clin Diagn Res, Apr 2015
Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function.
The role of Th1 and Th17 cells in glomerulonephritis.
Review
New
Rafieian-Kopaei et al., Sārī, Iran. In J Nephropathol, Apr 2015
CONCLUSIONS: Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
New
Impact
Dixit et al., San Francisco, United States. In Nature, Mar 2015
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases.
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
New
Impact
Xu et al., Ann Arbor, United States. In Nat Med, Oct 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
Anticytokine autoantibody-associated immunodeficiency.
Review
Impact
Browne, Bethesda, United States. In Annu Rev Immunol, 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Impact
Casanova et al., New York City, United States. In Immunity, 2013
Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic mucocutaneous candidiasis (CMC).
IL-17 cytokines in immunity and inflammation.
Review
Dong et al., Beijing, China. In Emerg Microbes Infect, 2013
Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology.
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Impact
Rawlings et al., Córdoba, Argentina. In Nat Immunol, 2013
With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
GeneRIF
Fuke et al., Hachiōji, Japan. In Gene, 2012
IL17F gene polymorphism 7488T>C influences bone mineral density.
Interleukin-33 induces interleukin-17F in bronchial epithelial cells.
GeneRIF
Hizawa et al., Tsukuba, Japan. In Allergy, 2012
data suggest that the IL-33/IL-17F axis is involved in allergic airway inflammation
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer.
GeneRIF
Pang et al., Harbin, China. In Plos One, 2011
Results suggested that single-nucleotide polymorphisms (SNPs) in IL-17A but not IL-17F were associated with the risk of breast cancer.
A protective role by interleukin-17F in colon tumorigenesis.
GeneRIF
Dong et al., Wuhan, China. In Plos One, 2011
Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis
[Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease].
GeneRIF
Efremov et al., In Eksp Klin Gastroenterol, 2010
Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease
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