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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Aug 2015.

Interleukin 17F

mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, CAN, IL-21, HAD, Interleukin-6
Papers on mL-1
IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies.
Review
New
Bissonnette et al., Portland, United States. In J Invest Dermatol, 31 Aug 2015
Generally, downstream deficiencies (e.g., IL-17A, IL-17F) are associated with fewer disorders compared with upstream deficiencies, suggesting that selectively blocking downstream targets may result in a narrower range of side effects.
Photoluminescent Lateral-Flow Immunoassay Revealed by Graphene Oxide: Highly Sensitive Paper-Based Pathogen Detection.
New
Merkoçi et al., In Anal Chem, 23 Aug 2015
The proposed device is able to display a highly specific and sensitive performance with a limit of detection of 10 CFU mL-1 in standard buffer and 100 CFU mL-1 in bottled water and milk.
Cigarette smoke affects IL-17A, IL-17F and IL-17 receptor expression in the lung tissue: Ex vivo and in vitro studies.
New
Profita et al., Palermo, Italy. In Cytokine, 18 Aug 2015
We aimed to evaluate the role of cigarette smoke on the expression of IL-17A, IL-17F and IL-17R in airways of COPD patients.
[Analysis of Cytokines Related to Helper T and Regulatory T Cells in the Vitreous of Uveitis Patients].
New
Takeuchi et al., In Nihon Ganka Gakkai Zasshi, Jun 2015
The vitreous levels of interleukin (IL)-1, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, interferon (IFN)-γ, soluble CD40 ligand (sCD40L) and tumor necrosis factor (TNF)-α were measured.
Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.
Review
New
Dumitraşcu et al., Cluj-Napoca / Kolozsvár, Romania. In World J Gastroenterol, Jun 2015
An efficient strategy for IBD therapy is represented by the combination of IL-17A and IL-17F in acute IL-17A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17F knockout, DSS-induced colitis have been observed.
Role of IL-25 in Immunity.
Review
New
Parizad et al., Īlām, Iran. In J Clin Diagn Res, Apr 2015
Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function.
The role of Th1 and Th17 cells in glomerulonephritis.
Review
New
Rafieian-Kopaei et al., Sārī, Iran. In J Nephropathol, Apr 2015
CONCLUSIONS: Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
New
Impact
Dixit et al., San Francisco, United States. In Nature, Mar 2015
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases.
Progress in Understanding Algal Bloom-Mediated Fish Kills: The Role of Superoxide Radicals, Phycotoxins and Fatty Acids.
New
Hallegraeff et al., Hobart, Australia. In Plos One, Dec 2014
Purified brevetoxins PbTx-2 and -3 (from Karenia brevis, LC50 of 22.1 versus 35.2 μg mL-1) and karlotoxin KmTx-2 (from Karlodinium; LC50 = 380 ng mL-1) could almost entirely account for the fish killing activity by those two dinoflagellates.
Correlation between acute myeloid leukemia and IL-17A, IL-17F, and IL-23R gene polymorphism.
New
Li et al., Chengdu, China. In Int J Clin Exp Pathol, Dec 2014
This CD4+ cell subgroup secretes highly homologous interleukin (IL)-17A and IL-17F, and also expresses IL-23 receptor (IL-23R) on the cell surface.
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
New
Impact
Xu et al., Ann Arbor, United States. In Nat Med, Oct 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
Anticytokine autoantibody-associated immunodeficiency.
Review
Impact
Browne, Bethesda, United States. In Annu Rev Immunol, 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Impact
Casanova et al., New York City, United States. In Immunity, 2013
Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic mucocutaneous candidiasis (CMC).
IL-17 cytokines in immunity and inflammation.
Review
Dong et al., Beijing, China. In Emerg Microbes Infect, 2013
Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology.
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Impact
Rawlings et al., Córdoba, Argentina. In Nat Immunol, 2013
With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
GeneRIF
Fuke et al., Hachiōji, Japan. In Gene, 2012
IL17F gene polymorphism 7488T>C influences bone mineral density.
Interleukin-33 induces interleukin-17F in bronchial epithelial cells.
GeneRIF
Hizawa et al., Tsukuba, Japan. In Allergy, 2012
data suggest that the IL-33/IL-17F axis is involved in allergic airway inflammation
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer.
GeneRIF
Pang et al., Harbin, China. In Plos One, 2011
Results suggested that single-nucleotide polymorphisms (SNPs) in IL-17A but not IL-17F were associated with the risk of breast cancer.
A protective role by interleukin-17F in colon tumorigenesis.
GeneRIF
Dong et al., Wuhan, China. In Plos One, 2011
Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis
[Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease].
GeneRIF
Efremov et al., In Eksp Klin Gastroenterol, 2010
Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease
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