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Interleukin 17F

mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, IL-21, CAN, Interleukin-6, HAD
Papers on mL-1
Self-Enhanced Electrochemiluminescence Nanorods of Tris(bipyridine) Ruthenium (II) Derivative and Its Sensing Application for detection of N-acetyl-β-D-glucosaminidase.
Yuan et al., In Anal Chem, 18 Feb 2016
Based on sandwiched immunoreactions, a simple and sensitive "signal-on" immunosensor is constructed for the detection of N-acetyl-β-D-glucosaminidase (NAG), a biomarker of diabetic nephropathy, with excellent linear in concentrations varying from 1 ng mL-1 to 0.5 pg mL-1 and a detection limit of 0.17 pg mL-1.
Cytotoxicityof Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity.
Hwu et al., Taiwan. In Chemistry, 12 Feb 2016
Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 is with higher cytotoxicity of ~30 g mL-1.
Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice.
Gao et al., In Reprod Fertil Dev, 11 Feb 2016
In in vitro-cultured ovaries, Rheb and GTP (is 100 ng mL-1 Rheb and 500 ng mL-1 GTP for 48 h) significantly increased follicle diameter, the percentage of primary and secondary follicles and the umber of thecal cells, and upregulated expression of mTOR, phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), eukaryotic initiation factor (eIF) 4F and cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1).
BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis.
Lu et al., Beijing, China. In Allergy, 11 Feb 2016
METHODS: Freshly isolated human blood Th17 cells and in vitro differentiated Th17 cells from IL-17F red fluorescent protein reporter mice were treated with dexamethasone, a potent glucocorticoid.
Proinflammatory T cells and IL-17 stimulate osteoblast differentiation.
Alblas et al., Utrecht, Netherlands. In Bone, 09 Feb 2016
IL-17 A and IL-17F, their main proinflammatory cytokines, similarly exhibited strong osteogenic effects when exposed directly to MSCs.
[Abnormal expression of IL- 23/IL- 17 axis in peripheral blood of 45 patients with primary immune thrombocytopenia].
Wu et al., Suzhou, China. In Zhonghua Xue Ye Xue Za Zhi, 14 Jan 2016
METHODS: The real-time quantitative reverse transcription-polymerase chain reaction(RT-PCR)was used to determine the expression of IL-23p19, p40, p35, IL-23R, IL-12Rβ1, IL-12Rβ2, IL-17A, IL-17F mRNA in the peripheral blood of 45 ITP patients and 30 healthy controls.
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Dixit et al., San Francisco, United States. In Nature, Mar 2015
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases.
Association of interleukin-17 gene polymorphisms and Helicobacter pylori infection with gastric cancer susceptibility: a cumulative and comprehensive meta-analysis.
Hu et al., Shiyan, China. In Int J Clin Exp Med, 2014
METHODS: PubMed, Embase, CNKI and Wanfang databases were researched on the associations between IL-17A rs2275913G>A, rs3748067C>T and IL-17F rs763780 T>C and gastric cancer risk.
Novel Bioactive Wild Medicinal Mushroom-Xylaria sp. R006 (Ascomycetes) against Multidrug Resistant Human Bacterial Pathogens and Human Cancer Cell Lines.
Rajendran et al., Madurai, India. In Int J Med Mushrooms, 2014
The fraction E showed a maximum inhibition zone of 27.9 mm against drug resistant S. aureus strain 3 and 29.4 mm against drug resistant P. aeruginosa strain 4. Minimal inhibitory concentration of fraction E showed potential result against all the drug resistant strains however, the lowest concentration of 75 µg/mL-1 was observed against S. aureus strains 1 and 6 and P. aeruginosa strain 3. Further, 60 µg/mL of fraction E had significant cytotoxic activity of 54.9, 55.1 and 54.9% against MDA-MB-231 (breast carcinoma cells), A-549 (lung carcinoma cells) and MCF-7 (breast carcinoma cells) human cancer cell lines, respectively.
Antioxidant Capacity and Total Phenolics Content of the Fruiting Bodies and Submerged Cultured Mycelia of Sixteen Higher Basidiomycetes Mushrooms from India.
Kumar et al., India. In Int J Med Mushrooms, 2014
The fruiting bodies and the culture mycelia of all the mushroom species exhibited varied antioxidant capacity; however, the fruiting bodies had more potent DPPH· scavenging than the corresponding mycelia irrespective of the mushroom species, as evident by the effective concentrations of extract that scavenges 50% of DPPH· (EC50) of the former (0.56-1.24 mg mL-1) being lower than those of the latter (2.51-8.39
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
Xu et al., Ann Arbor, United States. In Nat Med, 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
Anticytokine autoantibody-associated immunodeficiency.
Browne, Bethesda, United States. In Annu Rev Immunol, 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Casanova et al., New York City, United States. In Immunity, 2013
Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic mucocutaneous candidiasis (CMC).
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Rawlings et al., Córdoba, Argentina. In Nat Immunol, 2013
With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
Fuke et al., Hachiōji, Japan. In Gene, 2012
IL17F gene polymorphism 7488T>C influences bone mineral density.
Interleukin-33 induces interleukin-17F in bronchial epithelial cells.
Hizawa et al., Tsukuba, Japan. In Allergy, 2012
data suggest that the IL-33/IL-17F axis is involved in allergic airway inflammation
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer.
Pang et al., Harbin, China. In Plos One, 2011
Results suggested that single-nucleotide polymorphisms (SNPs) in IL-17A but not IL-17F were associated with the risk of breast cancer.
A protective role by interleukin-17F in colon tumorigenesis.
Dong et al., Wuhan, China. In Plos One, 2011
Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis
[Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease].
Efremov et al., In Eksp Klin Gastroenterol, 2010
Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease
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