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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Interleukin 17F

mL-1, IL-17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-17, CAN, IL-21, ACID, HAD
Papers on mL-1
Ultrasensitive and Quantitative Detection of a New β-Agonist Phenylethanolamine A by a Novel Immunochromatographic Assay Based on Surface-Enhanced Raman Scattering (SERS).
New
Deng et al., In J Agric Food Chem, 24 Nov 2014
The IC50 and limit of detection (LOD) values of the ICA for PA detection were 0.06 ng mL-1 and 0.32 pg mL-1, respectively, which were one to three orders of magnitude lower than those obtained by other immunoassays, indicating ultra-sensitivity of this ICA.
Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma.
New
Kachlany et al., Newark, United States. In J Leukoc Biol, 23 Nov 2014
LtxA caused resolution of disease in mice, as demonstrated by a decrease in BALF WBCs, a reduction in pulmonary inflammation and tissue remodeling, and a decrease in proinflammatory cytokines IL-4, IL-5, IL-9, IL-17F, and IL-23α in lung tissue.
Reduced susceptibility to vancomycin and biofilm formation in methicillin-resistant Staphylococcus epidermidis isolated from blood cultures.
New
Cunha et al., Botucatu, Brazil. In Mem Inst Oswaldo Cruz, 21 Nov 2014
Determination of the MIC of subpopulations revealed that 64.7% had an MIC ≥ 4 μg mL-1, including 15.7% with an MIC of 8 μg mL-1 and 2% with an MIC of 16 μg mL-1.
The intracellular Ca(2+) channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
New
Impact
Xu et al., Ann Arbor, United States. In Nat Med, 31 Oct 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
[Th17 cells and aplastic anemia].
New
Shen et al., Taiyuan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 30 Sep 2014
During the past few years, a novel family of CD4(+)T cell lineage was detected and named as Th17 cells because of its unique ability expressing IL-17, which also can produce IL-17A, IL-17F, IL-21, IL-22 and IL-26.
Targeting Th17 cells in autoimmune diseases.
Review
New
Yamagata et al., Cambridge, United States. In Trends Pharmacol Sci, 14 Sep 2014
Given that Th17 cells express IL-17 together with many other proinflammatory cytokines [IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor (GM-CSF)], targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.
Interleukin-17 in human inflammatory diseases.
Review
New
Shahneh et al., Tehrān, Iran. In Postepy Dermatol Alergol, Aug 2014
Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F.
Role of TH17 cytokines in the control of colorectal cancer.
Review
New
Stolfi et al., Roma, Italy. In Oncoimmunology, Jan 2014
Studies with murine models of CRC have delineated the mechanisms by which TH17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs.
Anticytokine autoantibody-associated immunodeficiency.
New
Impact
Browne, Bethesda, United States. In Annu Rev Immunol, Dec 2013
Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma.
Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis.
Review
New
Santos-Silva et al., Portugal. In Core Evid, Dec 2013
Brodalumab is a human monoclonal antibody that targets IL-17 receptor A, blocking the effects of IL-17A, IL-17F, and IL-17E.
[Role of Th17 lymphocytes in pathogenesis of colorectal cancer].
Review
New
Adamski et al., In Postepy Hig Med Dosw (online), Dec 2013
Th17 lymphocytes produce a number of pro-inflammatory cytokines, such as interleukin (IL)-17A, IL-17F, IL-21, IL-22 and tumor necrosis factor (TNF)-a, and play a key role in mucosal defense against various pathogens.
Meta Analysis of Association of the IL-17F rs763780T>C Gene Polymorphism with Cancer Risk.
New
Pu et al., Chengdu, China. In Asian Pac J Cancer Prev, Dec 2013
PURPOSE: To investigate the association of IL-17F rs763780T>C with cancer risk.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
New
Impact
Casanova et al., New York City, United States. In Immunity, Nov 2013
Patients with inborn errors of interleukin-17F (IL-17F) or IL-17RA display chronic mucocutaneous candidiasis (CMC).
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
New
Impact
Rawlings et al., Córdoba, Argentina. In Nat Immunol, May 2013
With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.
New
Impact
Baier et al., Innsbruck, Austria. In Immunity, Feb 2013
Consistently, Prkca(-/-) cells failed to mount appropriate IL-17A, but not IL-17F, responses in vitro and were resistant to induction of Th17-cell-dependent experimental autoimmune encephalomyelitis in vivo.
The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.
GeneRIF
Fuke et al., Hachiōji, Japan. In Gene, 2012
IL17F gene polymorphism 7488T>C influences bone mineral density.
Interleukin-33 induces interleukin-17F in bronchial epithelial cells.
GeneRIF
Hizawa et al., Tsukuba, Japan. In Allergy, 2012
data suggest that the IL-33/IL-17F axis is involved in allergic airway inflammation
Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer.
GeneRIF
Pang et al., Harbin, China. In Plos One, 2011
Results suggested that single-nucleotide polymorphisms (SNPs) in IL-17A but not IL-17F were associated with the risk of breast cancer.
A protective role by interleukin-17F in colon tumorigenesis.
GeneRIF
Dong et al., Wuhan, China. In Plos One, 2011
Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis
[Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease].
GeneRIF
Efremov et al., In Eksp Klin Gastroenterol, 2010
Dynamics of serum IL-17A, IL-17F and IL-23 in patients with inflammatory bowel disease
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