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Makorin ring finger protein 2

MKRN2, HSPC070
Members of the makorin family, including MKRN2, have a characteristic zinc finger composition that suggests that they are ribonucleoproteins (Gray et al., 2001 [PubMed 11597136]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Raf, TMPRSS3, FADS1, miR, MTMR4
Papers on MKRN2
Genetic Variations in MicroRNA-Binding Sites Affect MicroRNA-Mediated Regulation of Several Genes Associated With Cardio-metabolic Phenotypes.
New
Dehghan et al., Rotterdam, Netherlands. In Circ Cardiovasc Genet, Jun 2015
These cotransfection experiments showed that rs174545 (FADS1:miR-181a-2), rs1059611 (LPL:miR-136), rs13702 (LPL:miR-410), rs1046875 (FN3KRP:miR-34a), rs7956 (MKRN2:miR-154), rs3217992 (CDKN2B:miR-138-2-3p), and rs11735092 (HSD17B13:miR-375) decrease or abrogate miRNA-dependent regulation of the genes.
Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity.
Li et al., Hong Kong, Hong Kong. In Plos One, 2013
Makorin-2 (MKRN2) is a highly conserved protein and yet its functions are largely unknown.
Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications.
Swierniak et al., Gliwice, Poland. In Cancer Res, 2005
It included the following 19 genes: DPP4, GJB3, ST14, SERPINA1, LRP4, MET, EVA1, SPUVE, LGALS3, HBB, MKRN2, MRC2, IGSF1, KIAA0830, RXRG, P4HA2, CDH3, IL13RA1, and MTMR4, and correctly discriminated 17 of 18 additional PTC/normal thyroid samples and all 16 samples published in a previous microarray study.
Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.
GeneRIF
Nicholls et al., Cleveland, United States. In Genomics, 2001
MKRN2 and RAF1 are co-expressed in tissues and cell lines
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
Chen et al., Shanghai, China. In Genome Res, 2000
Interestingly, a new gene named as HSPC070 on 3p was found to share a sequence of 105bp in 3' UTR with RAF gene in reversed transcription orientation.
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