Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis.
Bern, Switzerland. In Sci Rep, 2014
Microarray expression profiling of normal versus starved H295R cells revealed fourteen differentially expressed genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction.
Relevance of vitamin D receptor target genes for monitoring the vitamin D responsiveness of primary human cells.
Kuopio, Finland. In Plos One, 2014
Network and self-organizing map analysis of these datasets together with that of the other 24 parameters was followed by relevance calculations and identified changes in parathyroid hormone serum levels and the expression of the newly selected genes STS, BCL6, ITGAM, LRRC25, LPGAT1 and TREM1 as well as of the previously reported genes DUSP10 and CD14 as the most relevant parameters for describing vitamin D responsiveness in vivo.
Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm.
United States. In Int J Mol Sci, 2014
Quantitative PCR assays confirmed a sub-set of the transcription factor binding sites including those in MTMR11, DUSP10, ITGAM, MARCH1, HDAC8, MMP14, MAGI1, THBD and SPOCK1.
Three-dimensional docking in the MAPK p38α.
Dallas, United States. In Sci Signal, 2012
The structure of a MAPK with a kinase-binding domain (KBD) from a MAPK phosphatase, MKP5, reveals that the contacts with the MAPK are made with the folded three-dimensional KBD, although the KBD occupies the same binding site on the kinase as canonical linear docking motifs found in substrates and MAPK kinases.