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Dual specificity phosphatase 1

MKP-1, VH1, VHI, MAP kinase phosphatase-1, DUSP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, p38, ERK, V1a, JNK
Papers using MKP-1 antibodies
Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity
Shen Beifen et al., In Molecular Cancer, 2003
... Antibodies against p38, DLC, actin, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Haugh Jason M et al., In Molecular Systems Biology, 1998
... Antibodies against Ras (Y13-259, agarose conjugated), Akt-1/2 N terminus, Erk-1 C terminus, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on MKP-1
AMP-activated Protein Kinase Suppresses Vascular Inflammation in vivo by Inhibiting Signal Transducer and Activator of Transcription-1.
Xie et al., Paris, France. In Diabetes, 09 May 2015
Mechanistically, we found that AMPK activation increased, whereas AMPK inhibition decreased, the levels of mitogen-activated protein kinase phosphatase-1 (MKP-1), an inducible nuclear phosphatase, by regulating proteasome-dependent degradation of MKP-1.
Global transcriptional changes following statin treatment in breast cancer.
Borgquist et al., Lund, Sweden. In Clin Cancer Res, 03 May 2015
Significantly up-regulated genes included DUSP1, RHOB1, GADD45B and RGS1.
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.
Stärkel et al., Brussels, Belgium. In Eur J Clin Invest, 01 May 2015
Down-regulation of several Ras/MAPK pathway inhibitors like GAPs, RASSF proteins, DUSP1, Sprouty and Spred proteins is largely implicated in the aberrant activation of this pathway in the context of wild-type Ras and Raf genes.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
Zou et al., Oklahoma City, United States. In Nat Med, 30 Apr 2015
Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 (AMPKα2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation.
MAP kinase phosphatase-1 expression is regulated by 15-deoxy-Δ(12,14)-prostaglandin J2 via a HuR-dependent post-transcriptional mechanism.
Jou et al., Suwŏn, South Korea. In Biochim Biophys Acta, 21 Apr 2015
UNASSIGNED: In the present study, we demonstrate a mechanism through which 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) induces MKP-1 expression in rat primary astrocytes, leading to the regulation of inflammatory responses.
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Lanzavecchia et al., Bellinzona, Switzerland. In Nature, Jan 2015
Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.
The effect of music performance on the transcriptome of professional musicians.
Järvelä et al., Helsinki, Finland. In Sci Rep, Dec 2014
Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production.
Targeting DUSPs in glioblastomas - wielding a double-edged sword?
Velpula et al., Lakeland, United States. In Cell Biol Int, Feb 2014
This review identifies and summarize the specific roles of DUSP1, DUSP4, DUSP6 and DUSP26 that have been implicated in GBM.
Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target.
Moilanen et al., Tampere, Finland. In Basic Clin Pharmacol Toxicol, 2014
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is an inducible nuclear phosphatase that dephosphorylates MAPKs, and thus, it is a negative feedback regulator of MAPK activity.
Mitogen-activated protein kinase signal transduction in solid tumors.
Wang et al., Nanchang, China. In Asian Pac J Cancer Prev, 2013
Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1.
The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
Chlubek et al., Szczecin, Poland. In J Physiol Pharmacol, 2013
NADPH oxidase increases the ROS levels, leading to inactivation of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein tyrosine phosphatase (PTP): MAPK phosphatase 1 (MKP-1).
MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus.
Ye et al., China. In Lupus, 2013
MKP-1, a prototypical member of the MKP family that can influence outcomes of autoimmune diseases and reduce the inflammatory cytokines by dephosphorylation of p38 and JNK MAPK, plays a critical role in the expression of inflammatory mediators at transcriptional and post-transcriptional levels.
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
Ammit et al., Sydney, Australia. In Biochim Biophys Acta, 2012
By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
Sobue et al., Nagoya, Japan. In Nat Med, 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Serrano et al., Madrid, Spain. In Cancer Cell, 2012
Mechanistically, we show that HES1 directly binds to and represses the promoter of DUSP1, encoding a dual phosphatase that is active against phospho-ERK.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Li et al., Atlanta, United States. In J Biol Chem, 2012
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
Moilanen et al., Tampere, Finland. In Mol Immunol, 2012
MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
Libert et al., Gent, Belgium. In J Clin Invest, 2012
GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation.
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
Chang et al., Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.
Chi et al., Memphis, United States. In Immunity, 2011
imprints distinct effector and regulatory T cell fates
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