GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 28 Jan 2015.
Dual specificity phosphatase 1
MKP-1, VH1, VHI, MAP kinase phosphatase-1, DUSP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
MAPK, p38, ERK, JNK, V1a
Papers using
MKP-1
antibodies
Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity
Supplier
In Molecular Cancer, 2003
... Antibodies against p38, DLC, actin, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Supplier
In Molecular Systems Biology, 1998
... Antibodies against Ras (Y13-259, agarose conjugated), Akt-1/2 N terminus, Erk-1 C terminus, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
MKP-1
Pro‑apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells.
New
Bochum, Germany. In Int J Oncol, 27 Feb 2015
Microarray analysis revealed remarkable expression changes induced by pycnogenol in a variety of genes, which are involved in different apoptotic pathways of cancer cells [Janus kinase 1 (JAK1), DUSP1, RHOA, laminin γ1 (LAMC1), fibronectin 1 (FN1), catenin α1 (CTNNA1), ITGB1].
Regulation of Inflammatory Cytokine Production by MKP-5 in Macrophages.
New
Tampere, Finland. In Basic Clin Pharmacol Toxicol, 23 Feb 2015
MKP-1 is the most studied member of MKP family, and it is one of the anti-inflammatory factors induced by glucocorticoids.
Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression.
New
Chŏnju, South Korea. In J Hepatol, 21 Feb 2015
BACKGROUND & AIMS: Altered expression of dual specificity phosphatase 1 (DUSP1) is common in tumors including hepatocellular carcinoma (HCC), and is predictive of tumor progression and poor prognosis.
Mechanism of glutamine inhibition of cytosolic phospholipase A2 (cPLA2 ): Evidence of physical interaction between glutamine-induced MAPK phosphatase-1 and cPLA2.
New
Chŏnju, South Korea. In Clin Exp Immunol, 20 Feb 2015
We previously showed that Gln indirectly deactivated cPLA2 via dephosphorylating p38 MAPK, the major kinase for cPLA2 phosphorylation, through inducing MAPK phosphatase-1 (MKP-1).
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
New
Impact
Bellinzona, Switzerland. In Nature, 18 Jan 2015
Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.
Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands.
New
Calgary, Canada. In Plos One, 31 Dec 2014
Dexamethasone-induced DUSP1 mRNA was unaffected.
Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target.
Review
Tampere, Finland. In Basic Clin Pharmacol Toxicol, 2014
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is an inducible nuclear phosphatase that dephosphorylates MAPKs, and thus, it is a negative feedback regulator of MAPK activity.
Mitogen-activated protein kinase signal transduction in solid tumors.
Review
Nanchang, China. In Asian Pac J Cancer Prev, 2013
Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1.
The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
Review
Szczecin, Poland. In J Physiol Pharmacol, 2013
NADPH oxidase increases the ROS levels, leading to inactivation of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein tyrosine phosphatase (PTP): MAPK phosphatase 1 (MKP-1).
MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus.
Review
China. In Lupus, 2013
MKP-1, a prototypical member of the MKP family that can influence outcomes of autoimmune diseases and reduce the inflammatory cytokines by dephosphorylation of p38 and JNK MAPK, plays a critical role in the expression of inflammatory mediators at transcriptional and post-transcriptional levels.
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
GeneRIF
Sydney, Australia. In Biochim Biophys Acta, 2012
By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
Impact
Nagoya, Japan. In Nat Med, 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Impact
Madrid, Spain. In Cancer Cell, 2012
Mechanistically, we show that HES1 directly binds to and represses the promoter of DUSP1, encoding a dual phosphatase that is active against phospho-ERK.
MKP-1: a critical phosphatase in the biology of macrophages controlling the switch between proliferation and activation.
Review
Barcelona, Spain. In Eur J Immunol, 2012
The length of phosphorylation is controlled by the MAPK phosphatase-1 (MKP-1), a nuclear-localized dual-specificity phosphatase that dephosphorylates the MAPKs ERK, p38, and c-Jun NH(2) -terminal kinase (JNK).
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
GeneRIF
Atlanta, United States. In J Biol Chem, 2012
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
GeneRIF
Gent, Belgium. In J Clin Invest, 2012
GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation.
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
GeneRIF
Tampere, Finland. In Mol Immunol, 2012
MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
GeneRIF
Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.
Impact
GeneRIF
Memphis, United States. In Immunity, 2011
imprints distinct effector and regulatory T cell fates
A negative regulator of MAP kinase causes depressive behavior.
Impact
GeneRIF
New Haven, United States. In Nat Med, 2010
MKP-1 is identified as a key factor in major depressive disorder pathophysiology.
