GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
Dual specificity phosphatase 1
MKP-1, VH1, VHI, MAP kinase phosphatase-1, DUSP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
MKP-1
antibodies
Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity
Supplier
In Molecular Cancer, 2003
... Antibodies against p38, DLC, actin, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Supplier
In Molecular Systems Biology, 1998
... Antibodies against Ras (Y13-259, agarose conjugated), Akt-1/2 N terminus, Erk-1 C terminus, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
MKP-1
Obstructive sleep apnea and intermittent hypoxia increase expression of dual specificity phosphatase 1.
New
Rochester, United States. In Atherosclerosis, 31 Dec 2013
OBJECTIVE: Dual specificity phosphatase 1 (DUSP1) inhibits mitogen activated protein kinase activity, and is activated by several stimuli such as sustained hypoxia, oxidative stress, and hormones.
A time-course analysis of mRNA expression during injury healing in human dermal injuries.
New
Auckland, New Zealand. In Int J Legal Med, 22 Dec 2013
In this study, the expression of the following 14 mRNAs was studied in human dermal injuries and their usefulness in the estimation of human dermal injury age was evaluated: dual specificity phosphate 1 (DUSP1), interleukin 7 (IL7), vascular cell adhesion molecule 1, tenascin C, cluster of differentiation 14, interleukin 6, tumour necrosis factor alpha (TNFα), interleukin 1beta (IL1β), chymase 1 (CMA1), collagen type III alpha I, interleukin 2, collagen type I alpha I, collagen type I alpha II and vascular endothelial growth factor A (VEGFA).
The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis.
New
Memphis, United States. In Apoptosis, 20 Dec 2013
MKP-1 knockdown by SiRNA increased ERK1/2, JNK1/2, and p38 phosphorylation and apoptosis.
MKP-1 Signaling Events are Required for Early Osteoclastogenesis in Lineage Defined Progenitor Populations by Disrupting RANKL-Induced NFATc1 Nuclear Translocation.
New
Charleston, United States. In Bone, 20 Dec 2013
MAPK phosphatase 1 (MKP-1), a serine and tyrosine phosphatase encoded by the gene Dusp1, functions to dephosphorylate and subsequently inactivate MAPK (p38 and JNK) signaling essential in osteoclastogenesis.
Proteomic, Cellular and Network Analyses Reveal New DUSP3 Interactions with Nucleolar Proteins in HeLa Cells.
New
In J Proteome Res, 18 Dec 2013
UNLABELLED: DUSP3 (or Vaccinia virus phosphatase VH1-related; VHR) is a small dual-specificity phosphatase known to dephosphorylate c-Jun N-terminal kinases (JNK) and extracellular signal-regulated kinases (ERK).
MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus.
Review
New
China. In Lupus, Feb 2013
MKP-1, a prototypical member of the MKP family that can influence outcomes of autoimmune diseases and reduce the inflammatory cytokines by dephosphorylation of p38 and JNK MAPK, plays a critical role in the expression of inflammatory mediators at transcriptional and post-transcriptional levels.
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
Review
New
Indianapolis, United States. In Febs J, Jan 2013
We also review available selective small molecule inhibitors developed for a number of PTPs, including PTP1B, TC-PTP, SHP2, lymphoid-specific tyrosine phosphatase, haematopoietic protein tyrosine phosphatase, CD45, PTPβ, PTPγ, PTPRO, Vaccinia H1-related phosphatase, mitogen-activated protein kinase phosphatase-1, mitogen-activated protein kinase phosphatase-3, Cdc25, YopH, mPTPA and mPTPB.
Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions.
Review
New
New Haven, United States. In Cell Mol Life Sci, Jan 2013
The archetypal MKP family member, MKP-1 has garnered much of the attention amongst its ten other MKP family members.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
New
Impact
Nagoya, Japan. In Nat Med, Oct 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
New
Impact
Madrid, Spain. In Cancer Cell, Sep 2012
Mechanistically, we show that HES1 directly binds to and represses the promoter of DUSP1, encoding a dual phosphatase that is active against phospho-ERK.
MKP-1: a critical phosphatase in the biology of macrophages controlling the switch between proliferation and activation.
Review
New
Barcelona, Spain. In Eur J Immunol, Aug 2012
The length of phosphorylation is controlled by the MAPK phosphatase-1 (MKP-1), a nuclear-localized dual-specificity phosphatase that dephosphorylates the MAPKs ERK, p38, and c-Jun NH(2) -terminal kinase (JNK).
S-Nitrosylation of mitogen activated protein kinase phosphatase-1 suppresses radiation-induced apoptosis.
New
GeneRIF
Beijing, China. In Cancer Lett, Feb 2012
S-nitrosylation of MKP-1 presents a novel mechanism underlying the enhanced MKP-1 expression levels and MKP-1-mediated radio-resistance in head and neck cancer.
[Research progress on MKP-1 in tumor drug resistance].
Review
Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2012
It has been reported that MKP-1 plays an important role in tumor drug resistance.
HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1.
GeneRIF
San Antonio, United States. In Ann N Y Acad Sci, 2011
TSA upregulates the expression of C/EBP-beta and MKP-1, which may downregulate pro-osteoclastogenic factors and signaling molecules, ultimately suppressing osteoclastogenesis.
Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus.
GeneRIF
Singapore, Singapore. In Virology, 2011
infectious bronchitis virus (IBV) infection of cultured cells activated p38 MAPK pathway and induced expression of IL6 and IL8; IBV has developed a strategy to counteract induction of IL6 and IL8 by inducing expression of dual-specificity phosphatase 1
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair.
GeneRIF
Barcelona, Spain. In J Cell Biol, 2011
novel regulatory mechanism involving the appropriate balance of p38, MKP-1, miR-21, and AKT activities may have implications in chronic inflammatory degenerative diseases.
Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma.
GeneRIF
Hangzhou, China. In J Zhejiang Univ Sci B, 2011
The imbalanced expression of MKP-1 and p-ERK(1/2) may play a role in the development of squamous cell carcinoma (SCC) and these two molecules may be new targets for the therapy and prognosis of SCC.
Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.
Impact
GeneRIF
Memphis, United States. In Immunity, 2011
imprints distinct effector and regulatory T cell fates
A negative regulator of MAP kinase causes depressive behavior.
Impact
GeneRIF
New Haven, United States. In Nat Med, 2010
MKP-1 is identified as a key factor in major depressive disorder pathophysiology.
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.
Review
Impact
Montréal, Canada. In Pharmacol Rev, 2008
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine dual-specificity phosphatases, one of more than 100 protein tyrosine phosphatases.
