SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
Chŏnju, South Korea. In J Am Soc Nephrol, 27 Nov 2014
In addition, SIRT2 interacted with mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), and SIRT2-knockdown increased the acetylation of MKP-1 and suppressed the phosphorylation of p38 MAPK and c-Jun N-terminal kinase in LPS-treated MPT cells.
Protein tyrosine phosphatases as potential therapeutic targets.
Indianapolis, United States. In Acta Pharmacol Sin, 15 Oct 2014
This review summarizes recent findings on several highly recognized PTP family drug targets, including PTP1B, Src homology phosphotyrosyl phosphatase 2,(SHP2), lymphoid-specific tyrosine phosphatase (LYP), CD45, Fas associated phosphatase-1 (FAP-1), striatal enriched tyrosine phosphatases (STEP), mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1), phosphatases of regenerating liver-1 (PRL), low molecular weight PTPs (LMWPTP), and CDC25.