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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2015.

Dual specificity phosphatase 1

MKP-1, VH1, VHI, MAP kinase phosphatase-1, DUSP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, p38, ERK, V1a, JNK
Papers using MKP-1 antibodies
Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity
Supplier
Shen Beifen et al., In Molecular Cancer, 2003
... Antibodies against p38, DLC, actin, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Supplier
Haugh Jason M et al., In Molecular Systems Biology, 1998
... Antibodies against Ras (Y13-259, agarose conjugated), Akt-1/2 N terminus, Erk-1 C terminus, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on MKP-1
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
New
Impact
Sodeoka et al., Wako, Japan. In Acc Chem Res, 19 Jun 2015
The resulting compounds showed dramatically improved cell membrane permeability and inhibitory selectivity and included VHR (vaccinia VH1-related)-selective RE12 and CDC25A/B (cell division cycle 25A/B)-selective RE44.
Vinpocetine Inhibits Streptococcus pneumoniae-Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media.
New
Li et al., Atlanta, United States. In J Immunol, 13 Jun 2015
Moreover, vinpocetine inhibited MUC5AC upregulation by inhibiting the MAPK ERK pathway in an MKP-1-dependent manner.
Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor.
New
Song et al., Inch'ŏn, South Korea. In Stem Cells Transl Med, 13 Jun 2015
MA also upregulated genes downstream of GR in ASCs, including ANGPTL4, DUSP1, ERRF11, FKBP5, GLUL, and TSC22D3.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
New
Impact
Zou et al., Oklahoma City, United States. In Nat Med, 30 Apr 2015
Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 (AMPKα2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation.
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
New
Impact
Lanzavecchia et al., Bellinzona, Switzerland. In Nature, Jan 2015
Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.
β-asarone from Acorus gramineus alleviates depression by modulating MKP-1.
New
Zhang et al., Qiqihar, China. In Genet Mol Res, Dec 2014
Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a negative regulatory protein of extracellular signal-regulated kinase signaling pathways.
Medical loss ratio as a potential regulatory tool in the Israeli healthcare system.
New
Kaplan et al., Beersheba, Israel. In Isr J Health Policy Res, Dec 2014
Our objective was to analyze how MLR is applied as a regulatory measure in the Israeli voluntary health insurance (VHI) market in order to promote the protection of beneficiaries.
Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids.
New
de-la-Hera et al., Madrid, Spain. In Mediators Inflamm, Dec 2014
In contrast, high GC doses did not change the expression of GILZ and DUSP1, while IGFBP1 was increased by 5-fold.
Protein tyrosine phosphatases as potential therapeutic targets.
Review
New
Zhang et al., Indianapolis, United States. In Acta Pharmacol Sin, Oct 2014
This review summarizes recent findings on several highly recognized PTP family drug targets, including PTP1B, Src homology phosphotyrosyl phosphatase 2(SHP2), lymphoid-specific tyrosine phosphatase (LYP), CD45, Fas associated phosphatase-1 (FAP-1), striatal enriched tyrosine phosphatases (STEP), mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1), phosphatases of regenerating liver-1 (PRL), low molecular weight PTPs (LMWPTP), and CDC25.
Targeting DUSPs in glioblastomas - wielding a double-edged sword?
Review
New
Velpula et al., Lakeland, United States. In Cell Biol Int, Feb 2014
This review identifies and summarize the specific roles of DUSP1, DUSP4, DUSP6 and DUSP26 that have been implicated in GBM.
Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target.
Review
Moilanen et al., Tampere, Finland. In Basic Clin Pharmacol Toxicol, 2014
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is an inducible nuclear phosphatase that dephosphorylates MAPKs, and thus, it is a negative feedback regulator of MAPK activity.
Mitogen-activated protein kinase signal transduction in solid tumors.
Review
Wang et al., Nanchang, China. In Asian Pac J Cancer Prev, 2013
Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1.
The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
Review
Chlubek et al., Szczecin, Poland. In J Physiol Pharmacol, 2013
NADPH oxidase increases the ROS levels, leading to inactivation of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein tyrosine phosphatase (PTP): MAPK phosphatase 1 (MKP-1).
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
GeneRIF
Ammit et al., Sydney, Australia. In Biochim Biophys Acta, 2012
By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
Impact
Sobue et al., Nagoya, Japan. In Nat Med, 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Impact
Serrano et al., Madrid, Spain. In Cancer Cell, 2012
Mechanistically, we show that HES1 directly binds to and represses the promoter of DUSP1, encoding a dual phosphatase that is active against phospho-ERK.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
GeneRIF
Li et al., Atlanta, United States. In J Biol Chem, 2012
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
GeneRIF
Moilanen et al., Tampere, Finland. In Mol Immunol, 2012
MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
GeneRIF
Libert et al., Gent, Belgium. In J Clin Invest, 2012
GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation.
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
GeneRIF
Chang et al., Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
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