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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Oct 2014.

Dual specificity phosphatase 1

MKP-1, VH1, VHI, MAP kinase phosphatase-1, DUSP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, p38, ERK, JNK, V1a
Papers using MKP-1 antibodies
Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity
Shen Beifen et al., In Molecular Cancer, 2003
... Antibodies against p38, DLC, actin, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Haugh Jason M et al., In Molecular Systems Biology, 1998
... Antibodies against Ras (Y13-259, agarose conjugated), Akt-1/2 N terminus, Erk-1 C terminus, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on MKP-1
Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy.
Nawroth et al., München, Germany. In Br J Cancer, 04 Dec 2014
cDNA or siRNA transfections were used to manipulate the expression of specific proteins such as wild-type or mutant PIK3CA, DUSP1 or CREB.
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.
Kim et al., Chŏnju, South Korea. In J Am Soc Nephrol, 27 Nov 2014
In addition, SIRT2 interacted with mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), and SIRT2-knockdown increased the acetylation of MKP-1 and suppressed the phosphorylation of p38 MAPK and c-Jun N-terminal kinase in LPS-treated MPT cells.
Paracrine Effects of Mesenchymal Stem Cells-Conditioned Medium on Microglial Cytokines Expression and Nitric Oxide Production.
Sam Wah Tay et al., Singapore, Singapore. In Neuroimmunomodulation, 21 Nov 2014
This study aimed to elucidate the effects of MSC-conditioned medium (MSC-CM) in modulating microglial activation by analyzing microglial proinflammatory and anti-inflammatory factors [interleukin (IL)-6, tumor necrosis factor (TNF)-α, inducible nitric oxide synthase (iNOS) and IL-10], signaling pathway molecules [NFκB, c-Jun N-terminal kinase (JNK) and MKP-1) and NO production.
Hepatic MAP kinase phosphatase-1 Selectively Regulates Glucose Metabolism and Energy Homeostasis.
Bennett et al., Danvers, United States. In Mol Cell Biol, 13 Nov 2014
However, the physiological contribution of MAPK phosphatase-1 (MKP-1) as a nuclear antagonist of both p38 MAPK and JNK in liver is unknown.
DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma.
Kirkwood et al., Oral, Kazakhstan. In Cancer Res, 13 Nov 2014
UNLABELLED: DUSP1 is a dual-specificity phosphatase that regulates mitogen-activated protein (MAP) kinase activity.
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Lanzavecchia et al., Bellinzona, Switzerland. In Nature, 05 Nov 2014
Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.
Protein tyrosine phosphatases as potential therapeutic targets.
Zhang et al., Indianapolis, United States. In Acta Pharmacol Sin, 15 Oct 2014
This review summarizes recent findings on several highly recognized PTP family drug targets, including PTP1B, Src homology phosphotyrosyl phosphatase 2,(SHP2), lymphoid-specific tyrosine phosphatase (LYP), CD45, Fas associated phosphatase-1 (FAP-1), striatal enriched tyrosine phosphatases (STEP), mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1), phosphatases of regenerating liver-1 (PRL), low molecular weight PTPs (LMWPTP), and CDC25.
Mitogen-activated protein kinase phosphatase 1 as an inflammatory factor and drug target.
Moilanen et al., Tampere, Finland. In Basic Clin Pharmacol Toxicol, Jan 2014
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is an inducible nuclear phosphatase that dephosphorylates MAPKs, and thus, it is a negative feedback regulator of MAPK activity.
The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
Chlubek et al., Szczecin, Poland. In J Physiol Pharmacol, Aug 2013
NADPH oxidase increases the ROS levels, leading to inactivation of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein tyrosine phosphatase (PTP): MAPK phosphatase 1 (MKP-1).
MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus.
Ye et al., China. In Lupus, Feb 2013
MKP-1, a prototypical member of the MKP family that can influence outcomes of autoimmune diseases and reduce the inflammatory cytokines by dephosphorylation of p38 and JNK MAPK, plays a critical role in the expression of inflammatory mediators at transcriptional and post-transcriptional levels.
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
Ammit et al., Sydney, Australia. In Biochim Biophys Acta, 2012
By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
Sobue et al., Nagoya, Japan. In Nat Med, 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Serrano et al., Madrid, Spain. In Cancer Cell, 2012
Mechanistically, we show that HES1 directly binds to and represses the promoter of DUSP1, encoding a dual phosphatase that is active against phospho-ERK.
MKP-1: a critical phosphatase in the biology of macrophages controlling the switch between proliferation and activation.
Celada et al., Barcelona, Spain. In Eur J Immunol, 2012
The length of phosphorylation is controlled by the MAPK phosphatase-1 (MKP-1), a nuclear-localized dual-specificity phosphatase that dephosphorylates the MAPKs ERK, p38, and c-Jun NH(2) -terminal kinase (JNK).
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Li et al., Atlanta, United States. In J Biol Chem, 2012
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
Libert et al., Gent, Belgium. In J Clin Invest, 2012
GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation.
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
Moilanen et al., Tampere, Finland. In Mol Immunol, 2012
MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
Chang et al., Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.
Chi et al., Memphis, United States. In Immunity, 2011
imprints distinct effector and regulatory T cell fates
A negative regulator of MAP kinase causes depressive behavior.
Duman et al., New Haven, United States. In Nat Med, 2010
MKP-1 is identified as a key factor in major depressive disorder pathophysiology.
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