GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Dual specificity phosphatase 1
MKP-1, VH1, VHI, MAP kinase phosphatase-1, DUSP1
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Top mentioned proteins:
MAPK, p38, ERK, V1a, JNK
Papers using
MKP-1
antibodies
Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity
Supplier
In Molecular Cancer, 2003
... Antibodies against p38, DLC, actin, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Supplier
In Molecular Systems Biology, 1998
... Antibodies against Ras (Y13-259, agarose conjugated), Akt-1/2 N terminus, Erk-1 C terminus, and MKP-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
MKP-1
Heparin decreases in TNFα;-induced endothelial stress responses require transmembrane protein 184A and induction of dual specificity phosphatase-1.
New
Lehigh Acres, United States. In J Biol Chem, Feb 2016
Studies with vascular smooth muscle cells (VSMCs)5 indicate a role for induction of dual specificity phosphatase 1 (DUSP1) that decreases ERK activity and results in decreased cell proliferation, which depends upon specific heparin binding.
Effect of Postoperative Proton Pump Inhibitor Therapy on Voice Outcomes Following Phonomicrosurgery for Vocal Fold Polyp: A Randomized Controlled Study.
New
Seoul, South Korea. In Clin Otolaryngol, Jan 2016
MAIN OUTCOME MEASURES: Voice handicap index (VHI) and perceptual and acoustic voice analysis were evaluated at baseline and 2 months after surgery.
9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury by suppressing MAPK signaling in mice.
New
Suwŏn, South Korea. In Br J Pharmacol, Jan 2016
9a decreased MKP-1 association with HDAC1 and enhanced MKP-1 acetylation and enhanced MKP-1 association with p-p38 and p-ERK.
Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm, Bombyx mori.
New
Chongqing, China. In Dev Comp Immunol, Jan 2016
Among the 36 PTP genes, ptp-h, which was proposed to be the origin of baculovirus ptp belongs to atypical VH1-like dual-specific PTP subset and encodes a catalytic active protein.
Regulation of Vascular Endothelium Inflammatory Signalling by Shear Stress.
New
Bristol, United Kingdom. In Curr Vasc Pharmacol, Jan 2016
In this review, we summarise the available evidence regarding the effect of shear stress on vascular EC and smooth muscle cells, the regulation of MAPK and NF-кB including the production of different negative regulators of inflammation such as MKP-1 and NRF2, and the production of microRNAs.
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.
Review
New
Brussels, Belgium. In Eur J Clin Invest, Jun 2015
Downregulation of several Ras/MAPK pathway inhibitors such as GAPs, RASSF proteins, DUSP1, Sprouty and Spred proteins is largely implicated in the aberrant activation of this pathway in the context of wild-type Ras and Raf genes.
Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases.
Review
New
Suwŏn, South Korea. In Exp Neurobiol, Jun 2015
This work has shown that the JAK-STAT pathway and its downstream are negatively regulated by phosphatases (SHP2 and MKP-1), inhibitory proteins (SOCS1 and SOCS3) and a nuclear receptor (LXR).
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
New
Impact
Wako, Japan. In Acc Chem Res, Jun 2015
The resulting compounds showed dramatically improved cell membrane permeability and inhibitory selectivity and included VHR (vaccinia VH1-related)-selective RE12 and CDC25A/B (cell division cycle 25A/B)-selective RE44.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
New
Impact
Oklahoma City, United States. In Nat Med, Apr 2015
Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 (AMPKα2) in adipocytes, which in turn phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, initiating its proteasome-dependent degradation.
Mitogen-activated protein kinase phosphatase-1: a critical phosphatase manipulating mitogen-activated protein kinase signaling in cardiovascular disease (review).
Review
New
Shanghai, China. In Int J Mol Med, Apr 2015
In recent years, accumulating and compelling evidence from studies mainly employing cultured cells and mouse models has suggested that the archetypal MKP family member, MKP-1, plays a pivotal role in cardiovascular disease as a major negative modulator of MAPK signaling pathways.
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Impact
Bellinzona, Switzerland. In Nature, 2015
Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonstrate that they bind to the haemagglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.
Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head.
Review
In Microbiol Spectr, 2014
The germ line-encoded Phe54 residue of the CDR-H2 of the VH1-69 germ line sequence appears to be ideally suited not only to reach into a conserved, hydrophobic pocket on the HA stem, but also to reach into the conserved, hydrophobic pocket that is the RBD.
Mitogen-activated protein kinase signal transduction in solid tumors.
Review
Nanchang, China. In Asian Pac J Cancer Prev, 2013
Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1.
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
GeneRIF
Sydney, Australia. In Biochim Biophys Acta, 2012
By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1.
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.
Impact
Nagoya, Japan. In Nat Med, 2012
Naratriptan, a serotonin 1B/1D (5-hydroxytryptamine 1B/1D, or 5-HT1B/1D) receptor agonist, decreased CGRP1 expression via the induction of dual-specificity protein phosphatase 1 (DUSP1), attenuated JNK activity and mitigated pathogenic AR-mediated neuronal damage in cellular and mouse SBMA models.
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Impact
Madrid, Spain. In Cancer Cell, 2012
Mechanistically, we show that HES1 directly binds to and represses the promoter of DUSP1, encoding a dual phosphatase that is active against phospho-ERK.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
GeneRIF
Atlanta, United States. In J Biol Chem, 2012
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
GeneRIF
Tampere, Finland. In Mol Immunol, 2012
MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.
GeneRIF
Gent, Belgium. In J Clin Invest, 2012
GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation.
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
GeneRIF
Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
