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Mitogen-activated protein kinase kinase 7

MKK7, Mitogen-Activated Protein Kinase 7, JNKK2
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JNK, AP-1, MKK4, MAPK, p38
Papers using MKK7 antibodies
Rac and Rap GTPase activation assays.
Supplier
Hartl Dominik, In PLoS ONE, 2006
... MKK2, and Rac1 from BD Biosciences (Franklin Lakes, NJ); MKK6 from Biolegend (San Diego, CA); MKK7 (ab18565) was from Abcam (Cambridge, MA); cortactin (p80/85 ...
Papers on MKK7
Krüppel-like factor 5 promotes apoptosis triggered by tumor necrosis factor α in LNCaP prostate cancer cells via up-regulation of mitogen-activated protein kinase kinase 7.
New
Guo et al., Xi'an, China. In Urol Oncol, Feb 2016
We found that knockdown of KLF5 not only decreased the phosphorylation of JNK induced by TNFα, but also down-regulated the transcription of mitogen-activated protein kinase kinase 7 (MKK7), an upstream kinase of JNK, by binding to the MKK7 promoter.
Identification and characterization of MKK7 as an upstream activator of JNK in Litopenaeus vannamei.
New
Li et al., Guangzhou, China. In Fish Shellfish Immunol, Jan 2016
Mitogen-activated protein kinase kinase 7 (MKK7) is a key signal transduction regulator in c-Jun N-terminal kinase (JNK) signaling pathway, which is involved in a wide range of physiological and pathological processes.
HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells.
New
Yuan et al., Guangzhou, China. In Oncotarget, Jan 2016
Unexpectedly, HDACI treatment caused MKK7 downregulation at both the protein and mRNA levels.
Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.
New
Lynch et al., Philadelphia, United States. In Genes Dev, Nov 2015
Here we demonstrate that, in response to T-cell activation, the Jun kinase (JNK) kinase MAP kinase kinase 7 (MKK7) is alternatively spliced to favor an isoform that lacks exon 2. This isoform restores a JNK-docking site within MKK7 that is disrupted in the larger isoform.
CIP2A overexpression induces autoimmune response and enhances JNK signaling pathway in human lung cancer.
Zhang et al., El Paso, United States. In Bmc Cancer, 2014
Furthermore, the expression level of CIP2A also affected the phosphorylation of the upstream kinase of JNK, MKK4/MKK7.
Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors.
Impact
Franzoso et al., Napoli, Italy. In Cancer Cell, 2014
Here, we identify the interaction between the NF-κB-regulated antiapoptotic factor GADD45β and the JNK kinase MKK7 as a therapeutic target in MM.
Whipping NF-κB to Submission via GADD45 and MKK7.
Impact
Karin, San Diego, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Tornatore and colleagues solve this problem by targeting the GADD45:MKK7 module mediating NF-κB-induced survival of multiple myelomas.
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.
Impact
Zender et al., Hannover, Germany. In Cell, 2013
Mechanistically, induction of MKK7 and a JNK1-dependent activation of the AP1 transcription factor ATF2 and the Ets factor ELK1 are crucial for increased regeneration of hepatocytes with MKK4 silencing.
Gadd45 in the liver: signal transduction and transcriptional mechanisms.
Review
Locker et al., Pittsburgh, United States. In Adv Exp Med Biol, 2012
Gadd45β binds MKK7-downstream of TNFα and its receptors-to prevent this kinase from activating JNK2.
HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module.
GeneRIF
Zheng et al., Xuzhou, China. In World J Gastroenterol, 2012
Data show that HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression.
Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis-diammined dichloridoplatium.
GeneRIF
Wang et al., Dalian, China. In Oncol Rep, 2012
Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis-diammined dichloridoplatium.
Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock.
GeneRIF
Nishina et al., Tokyo, Japan. In J Biol Chem, 2012
a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.
Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies.
Review
Tournier et al., Manchester, United Kingdom. In Biochem Soc Trans, 2012
The remaining level of JNK activity in cells lacking MKK4 expression led to the discovery of a second activator of JNK, named MKK7.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
GeneRIF
Xia et al., Cincinnati, United States. In J Biol Chem, 2012
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
GeneRIF
Nishina et al., Tokyo, Japan. In J Neurosci, 2011
This study demonistrated that Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7.
Review
Waetzig et al., Kiel, Germany. In Eur J Cell Biol, 2011
MKK4 and MKK7 share similar molecular characteristics as well as several upstream activators and scaffold proteins.
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Impact
Penninger et al., Vienna, Austria. In Nat Genet, 2011
Here we report that tissue-specific inactivation of the stress signaling kinase MKK7 in KRas(G12D)-driven lung carcinomas and NeuT-driven mammary tumors markedly accelerates tumor onset and reduces overall survival.
Diverse physiological functions of MKK4 and MKK7 during early embryogenesis.
Review
Nishina et al., Tokyo, Japan. In J Biochem, 2010
Two MAPKKs that are crucial transducers upstream of JNK signalling are MKK4 and MKK7.
The role of metastasis suppressor genes in metastatic dormancy.
Review
Steeg et al., Bethesda, United States. In Apmis, 2008
MKK4, MKK7 and Nm23-H1 appear to promote dormancy of micrometastatic colonies, after disseminated tumor cells have undergone several rounds of proliferation.
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.
Impact
Lin et al., Houston, United States. In Immunity, 2007
This CARMA1-dependent regulation of JNK2 worked through the scaffold molecule Bcl10, which was inducibly associated with JNK2 and served as a JNK-interacting protein (JIP)-like scaffold to assemble the kinases JNK2, MKK7, and TAK1.
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