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Mitogen-activated protein kinase kinase 6

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, MAPK, Mitogen-Activated Protein Kinase 3, JNK, AP-1
Papers using MKK6 antibodies
Rac and Rap GTPase activation assays.
Hartl Dominik, In PLoS ONE, 2006
... Cell Signaling (Danvers, MA); paxillin, E-cadherin, MKK2, and Rac1 from BD Biosciences (Franklin Lakes, NJ); MKK6 from Biolegend (San Diego, CA); MKK7 ...
Acute hypertension activates mitogen-activated protein kinases in arterial wall
Sobue Kenji et al., In The Journal of Cell Biology, 1995
... Polyclonal antibodies against PKB(Akt), ERK, JNK, p38MAPK, MEK1, and MKK6 were obtained from Santa Cruz Biotechnology ...
Papers on MKK6
Suppression of phospho-p85α-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion.
Lin et al., Taiwan. In Mol Carcinog, Feb 2016
Treatment with TSWU-CD4 inhibited MMP-2 expression and cell invasion, which were restored by ectopic wild type (wt) p85α or a constitutively active form of MAPK kinase 3 (CA MKK3), CA MKK6, or CA p38α mitogen-activated protein kinase (MAPK).
MKK6 from pacific white shrimp Litopenaeus vannamei is responsive to bacterial and WSSV infection.
Li et al., Guangzhou, China. In Mol Immunol, Jan 2016
UNASSIGNED: p38 mitogen-actived protein kinases (MAPKs) broadly exist from yeast to mammals and participate in diverse cellular responses to various stimuli, whose activation can be induced by the MAPK kinase 6 (MKK6).
Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK.
Shin et al., Ch'ŏnan, South Korea. In Mech Ageing Dev, Jan 2016
The early onset of senescence in chondrocyte harboring MKK6E, which is a constitutively-active form of MKK6 and increases p38MAPK phosphorylation, was blocked by CsA.
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.
Swann et al., San Diego, United States. In Bioorg Med Chem Lett, Dec 2015
The Map Kinase Kinase isoforms 3 and 6 (MKK3 and MKK6) are responsible for the phosphorylation and activation of p38, and are hypothesized to play a key role in regulating this pathway without the redundancy seen in downstream effectors.
Delivery of Constitutively Active Mutant MKK6(E) With TAT-OSBP Induces Apoptosis in Human Ovarian Carcinoma HO8910 Cells.
Shuai et al., Guangzhou, China. In Int J Gynecol Cancer, Nov 2015
In this study, we evaluated the tumor selectivity, cellular internalization, and biological activity of a cell-permeable ovarian cancer cell-specific therapeutic protein consisting of TAT-OSBP and constitutively active MKK6(E), an upstream kinase of the p38 signaling pathway that mediates cellular apoptosis.
[Study of Mechanism of Esophageal Cancer Development through MKK6 Over-expression Regulated SIRTI Expression Level].
In Sichuan Da Xue Xue Bao Yi Xue Ban, Jul 2015
OBJECTIVE: To observe the influence of silent information regulator of transcription 1 (SIRT1) level by regulation of MKK6 over-expression in esophageal cancer cell Eca109, and then to explore the relationship between p38-MAPK-SIRT1 axis and progressing of esophageal cancer.
Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury.
Wu et al., New York City, United States. In Adv Exp Med Biol, 2014
This activation of ASK-1 is followed by activation of the mitogen-activated kinase kinases MKK3/MKK6 and MKK4/MMK7 and subsequently p38 and JNK MAP kinases.
Mitogen-activated protein kinase kinase 6 mediates mechanical stretch-induced high-mobility group box 1 protein expression in pulmonary alveolar epithelial cells.
She et al., Guangzhou, China. In J Trauma Acute Care Surg, 2012
activation by mechanical stretch induces HMGB1 and cytokine expression in A549 cells
Translational control of NKT cell cytokine production by p38 MAPK.
Boyson et al., Burlington, United States. In J Immunol, 2011
Impaired cytokine production in natural killer (NK)T cells is demonstrated from MKK3-deficient6+/- mice.
Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes.
Datta et al., Philadelphia, United States. In J Cell Biochem, 2011
Results suggest that the p38alpha, MAPK, and MKK6 play prominent roles in IL-1beta and C/EBP-beta-mediated C3 gene expression in astrocytes.
Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding.
Wu et al., Hong Kong, Hong Kong. In Proc Natl Acad Sci U S A, 2011
MKK6 and other MAP2Ks are a distinct class of cellular redox sensors
Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.
Sánchez-Prieto et al., Albacete, Spain. In Plos One, 2010
the balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC
GRK2-dependent desensitization downstream of G proteins.
Murga et al., Madrid, Spain. In J Recept Signal Transduct Res, 2007
The T123phospho-mimetic mutant of p38 shows a reduced ability to bind to MKK6, concomitant with an impaired p38 activation, and a decreased phosphorylation of downstream substrates such as MEF2, MK2 and ATF2.
Mirk/Dyrk1B in cancer.
Friedman, Syracuse, United States. In J Cell Biochem, 2007
Mirk is activated by phosphorylation by the stress-activated SAPK kinases MKK3 and MKK6.
TGF beta signalling and its role in tumour pathogenesis.
Danilkiewicz et al., Warsaw, Poland. In Acta Biochim Pol, 2004
Furthermore, TGF-beta-activated kinase-1 (TAK1) is a component of TGF-beta signalling and activates stress-activated kinases: p38 through MKK6 or MKK3 and c-Jun N-terminal kinases (JNKs) via MKK4.
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.
Puri et al., Roma, Italy. In Nat Genet, 2004
The SWI-SNF subunit BAF60 could be phosphorylated by p38 alpha-beta in vitro, and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active MKK6 (refs.
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Ichijo et al., Tokyo, Japan. In Antioxid Redox Signal, 2002
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein (MAP) kinase kinase kinase family, which activates both the MKK4/MKK7-JNK and MKK3/MKK6-p38 MAP kinase pathways and constitutes a pivotal signaling pathway in various types of stress-induced apoptosis.
TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
Chen et al., Dallas, United States. In Nature, 2001
Moreover, the activity of TAK1 to phosphorylate MKK6, which activates the JNK-p38 kinase pathway, is directly regulated by K63-linked polyubiquitination.
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.
Takahama et al., Tsukuba, Japan. In Immunity, 1998
We also show that the MKK6-p38 signaling pathway is critically involved in inducing negative selection of thymocytes.
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Gotoh et al., Tokyo, Japan. In Science, 1997
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively.
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