Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.
San Diego, United States. In Bioorg Med Chem Lett, Dec 2015
The Map Kinase Kinase isoforms 3 and 6 (MKK3 and MKK6) are responsible for the phosphorylation and activation of p38, and are hypothesized to play a key role in regulating this pathway without the redundancy seen in downstream effectors.
GRK2-dependent desensitization downstream of G proteins.
Madrid, Spain. In J Recept Signal Transduct Res, 2007
The T123phospho-mimetic mutant of p38 shows a reduced ability to bind to MKK6, concomitant with an impaired p38 activation, and a decreased phosphorylation of downstream substrates such as MEF2, MK2 and ATF2.
Mirk/Dyrk1B in cancer.
Syracuse, United States. In J Cell Biochem, 2007
Mirk is activated by phosphorylation by the stress-activated SAPK kinases MKK3 and MKK6.
TGF beta signalling and its role in tumour pathogenesis.
Warsaw, Poland. In Acta Biochim Pol, 2004
Furthermore, TGF-beta-activated kinase-1 (TAK1) is a component of TGF-beta signalling and activates stress-activated kinases: p38 through MKK6 or MKK3 and c-Jun N-terminal kinases (JNKs) via MKK4.