gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger and BTB domain containing 17

Miz-1, Siz2, PIASxbeta, Miz
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: c-Myc, CAN, Smt3, Ubiquitin, V1a
Papers on Miz-1
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
New
Impact
Roussel et al., Memphis, United States. In Cancer Cell, Feb 2016
Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin.
Parsing Myc Paralogs in Oncogenesis.
New
Impact
Eisenman et al., Seattle, United States. In Cancer Cell, Feb 2016
In this issue of Cancer Cell, Vo and colleagues (2016) show that this phenotypic difference stems from the preferential ability of Myc, relative to MycN, to bind Miz1 and repress transcription.
SIZ1-Dependent Post-Translational Modification by SUMO Modulates Sugar Signaling and Metabolism in Arabidopsis thaliana.
New
Azevedo et al., Porto, Portugal. In Plant Cell Physiol, Dec 2015
The Arabidopsis SUMO E3 ligase SAP and Miz 1 (SIZ1) is the major SUMO conjugation enhancer in response to stress, and is implicated in several aspects of plant development.
Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study.
New
Wu et al., Shanghai, China. In Dig Dis Sci, Dec 2015
AIM: We tested our hypothesis that Myc-interacting zinc finger protein 1 (MIZ1), a cell cycle regulator, suppressed inflammation, and therefore, represented a useful prognostic marker in patients with acute necrotizing pancreatitis (ANP) complicated by acute lung injury.
Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death.
New
Liu et al., Chicago, United States. In Oncogene, Aug 2015
UNASSIGNED: The transcription factor Miz1 negatively regulates TNF-induced JNK activation and cell death by suppressing TRAF2 K63-polyubiquitination; upon TNF stimulation, the suppression is relieved by Mule/ARF-BP1-mediated Miz1 ubiquitination and subsequent degradation.
PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.
New
Ulisse et al., Roma, Italy. In J Biol Regul Homeost Agents, Jul 2015
In particular, we evaluated the expression of the SENP1 to SENP8 (SENtrin-specific proteases), SAE1 (SUMO1 activating enzyme subunit 1), UBA2 (UBiquitin-like modifier activating enzyme 2), UBC9 (UBiquitin conjugating enzyme 9), RanBP2 (RAN binding protein 2), MSMCE2 (Non- SMC element 2), CBX4 (ChromoBoX homolog 4), PIAS1 to PIAS4 (protein inhibitor of activated STAT), ZMIZ1 (zinc finger, MIZ-type containing 1) and ZMIZ2 (Zinc finger, MIZ-type containing 2) by means of quantitative RT-PCR.
Taming of the beast: shaping Myc-dependent amplification.
Review
New
Levens et al., Würzburg, Germany. In Trends Cell Biol, Apr 2015
The level of Myc binding at target genes and the transcriptional output are differentially modulated by additional regulators, including Miz1.
Sleeping Beauty Transposition.
Review
New
Izsvák et al., In Microbiol Spectr, Apr 2015
Through its association with the Miz-1 transcription factor, the SB transposase downregulates cyclin D1 expression that results in a slowdown of the cell-cycle in the G1 phase, where NHEJ is preferentially active.
Functional characterization of DnSIZ1, a SIZ/PIAS-type SUMO E3 ligase from Dendrobium.
Wang et al., Guangzhou, China. In Bmc Plant Biol, 2014
The PIAS (protein inhibitor of activated signal transducers and activators of transcription [STAT]) and SIZ (scaffold attachment factor A/B/acinus/PIAS [SAP] and MIZ) proteins are SUMO E3 ligases that modulate SUMO conjugation.
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
Impact
Eilers et al., Würzburg, Germany. In Nature, 2014
Third, complex formation with MIZ1 (also known as ZBTB17) mediates repression of multiple target genes by MYC and the ratio of MYC and MIZ1 bound to each promoter correlates with the direction of response.
The role of MIZ-1 in MYC-dependent tumorigenesis.
Review
Eilers et al., Würzburg, Germany. In Cold Spring Harb Perspect Med, 2013
We propose that the interaction of MYC with the zinc finger protein MIZ-1 mediates resistance to antimitogenic signals.
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.
Impact
Liu et al., Chicago, United States. In Nat Immunol, 2013
Here we report that the transcription factor Miz1 was required for terminating lipopolysaccharide (LPS)-induced inflammation.
Molecular mechanisms of hydrotropism in seedling roots of Arabidopsis thaliana (Brassicaceae).
Review
Takahashi et al., Sendai, Japan. In Am J Bot, 2013
We identified MIZU-KUSSEI1 (MIZ1) and MIZ2, essential genes for hydrotropism in roots; the former encodes a protein of unknown function, and the latter encodes an ARF-GEF (GNOM) protein involved in vesicle trafficking.
Root hydrotropism: an update.
Review
Campos et al., Cuernavaca, Mexico. In Am J Bot, 2013
Current genetic analysis of hydrotropism in Arabidopsis has offered new players, mainly AHR1, NHR1, MIZ1, and MIZ2, which seem to modulate how root caps sense and choose to respond hydrotropically as opposed to other tropic responses.
The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae.
GeneRIF
Mishra et al., Hyderābād, India. In Eukaryot Cell, 2012
The sumoylating activity of Siz2 at the nuclear periphery acts to maintain a balance of sumoylation that supports the localization of Sir2/Sir4 to these silent regions.
The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
GeneRIF
Zwerschke et al., Innsbruck, Austria. In Virology, 2012
study demonstrate that HPV-16 E7 forms a complex with Miz-1; These findings suggest that HPV-16 E7 protein can repress Miz-1-induced p21(Cip1) gene expression
Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1.
GeneRIF
Hu et al., Yangzhou, China. In Febs Lett, 2012
Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1.
Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.
GeneRIF
Lin et al., Chicago, United States. In Proc Natl Acad Sci U S A, 2012
The repression of TNF-alpha-induced JNK activation by Miz1 is de-repressed by its own site-specific ubiquitination and degradation.
Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
GeneRIF
Elsässer et al., Marburg an der Lahn, Germany. In Plos One, 2011
Our data demonstrate that Miz1-mediated attenuation of cell cycle arrest pathways via repression of cdkn1a has a critical role during tumorigenesis in the skin.
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.
Impact
GeneRIF
Gasser et al., Basel, Switzerland. In Nat Cell Biol, 2011
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.
share on facebooktweetadd +1mail to friends