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Mitogen-activated protein kinase kinase 1

mitogen-activated protein kinase, Mitogen-Activated Protein Kinase 1, MEK1
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, p38, V1a, ERK, CAN
Papers using mitogen-activated protein kinase antibodies
Adipocytes impair leukemia treatment in mice
Heisterkamp Nora et al., In Oncoimmunology, 2008
... The MEK1/2 inhibitor U0126 was from Cell Signaling (cat no 9903) ...
Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-κB, STAT3 and C/EBP signaling pathways
Yang Chia-Ron et al., In Journal of Biomedical Science, 2008
... Phosphor-MKK3/MKK6 (Ser189/207), MKK3, MEK1/2 and rabbit monoclonal antibodies against phosphor-IκBaα (Ser32), phosphor-p65 (Ser536), phosphor-JNK (Thr183/Tyr185), phosphor-MEK1/2 (Ser217/221) were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
Zheng Jialin Charles, In PLoS ONE, 2008
... inhibitor), 10 µM SB203580 (p38 MAPK inhibitor), 10 µM LY294002 (PI3K inhibitor) or 5 µM U-0126 (MEK1/2 inhibitor) (Cayman Chemicals, Ann Arbor, Michigan) ...
Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets
Wu Nanping et al., In Journal of Biomedicine and Biotechnology, 2005
... B inhibitor Helenalin, JAK2/3 inhibitor AG490, p38MAPK inhibitor SB202190, and the MEK1/2 inhibitor PD98059 were purchased from Merck (Gibbstown, USA) and used ...
The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF
van Wijnen Andre J et al., In Breast Cancer Research : BCR, 2004
... Inhibition of MAPK dependent signaling pathways was carried out by treatment with the MEK1 inhibitor PD98059 (#9900, Cell Signaling Technology, Inc., Beverly, MA, ...
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Papers on mitogen-activated protein kinase
Novel Drugs and Combination Therapies for the Treatment of Metastatic Melanoma.
Terjanian et al., United States. In J Clin Med Res, Feb 2016
In last two decades, treatment of melanoma took a dramatic turn with the discovery of targeted therapy which targets the mutations in mitogen-activated protein kinase (MAPK) pathway and immune checkpoint inhibitors.
A scaffold protein Ahk1 that associates with Hkr1, Sho1, Ste11 and Pbs2 inhibits cross-talk signaling from the Hkr1 osmosensor to the Kss1 MAPK.
Tatebayashi et al., Tokyo, Japan. In Mol Cell Biol, Feb 2016
UNASSIGNED: In the budding yeast Saccharomyces cerevisiae, osmostress activates the Hog1 mitogen-activated protein kinase (MAPK), which regulates diverse osmoadaptive responses.
Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells.
Kim et al., Taegu, South Korea. In Int Forum Allergy Rhinol, Feb 2016
Cadmium significantly activated phosphorylation of extracellular signal related kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and p38 MAPK.
Combination therapy with BRAF and MEK inhibitors for melanoma: latest evidence and place in therapy.
Ribas et al., Tampa, United States. In Ther Adv Med Oncol, Jan 2016
Preclinical studies have suggested that concurrent inhibition of the BRAF kinases and MEK of the mitogen-activated protein kinase (MAPK) pathway could decrease MAPK-driven acquired resistance, resulting in longer duration of responses, higher rate of tumor responses, and a decrease in the cutaneous toxicities observed from paradoxical MAPK pathway activation with BRAF inhibitor monotherapy.
Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities.
Buscail et al., Toulouse, France. In Eur J Cancer, Jan 2016
Targeting of KRAS to treat pancreatic adenocarcinoma has been applied at different stages of RAS molecular intracellular processes: at the transcription level with antisense or interference RNA, at the posttranslational level with inhibitors of farnesyl transferase or anti-RAS vaccination peptides, and to target multiple signalling pathways using inhibitors of mitogen-activated protein kinase, phosphoinositide 3-kinase, AKT, mammalian target of rapamycin, RAF.
Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network.
Lim et al., San Francisco, United States. In Science, Jan 2016
The misperception results from the capacity of the osmolarity-sensing mitogen-activated protein kinase (MAPK) network to retrigger with sequential osmotic stresses.
MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy.
Maverakis et al., Sacramento, United States. In Drug Des Devel Ther, Dec 2015
Unfortunately, complex compensation mechanisms, such as those of the mitogen-activated protein kinase (MAPK) pathway, have limited the clinical benefit of these treatments.
Morin Attenuates Ovalbumin-Induced Airway Inflammation by Modulating Oxidative Stress-Responsive MAPK Signaling.
Huang et al., Nanjing, China. In Oxid Med Cell Longev, Dec 2015
The supernatant was collected for the detection of the proinflammatory proteins, and the cells were collected for reactive oxygen species (ROS)/mitogen-activated protein kinase (MAPK) evaluations.
Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals.
Di Pietro et al., Córdoba, Spain. In Nature, Dec 2015
The chemotropic response requires conserved elements of the fungal cell integrity mitogen-activated protein kinase (MAPK) cascade and the seven-pass transmembrane protein Ste2, a functional homologue of the Saccharomyces cerevisiae sex pheromone α receptor.
The Genetic Evolution of Melanoma from Precursor Lesions.
Bastian et al., Australia. In N Engl J Med, Dec 2015
RESULTS: Precursor lesions were initiated by mutations of genes that are known to activate the mitogen-activated protein kinase pathway.
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Ashwell et al., Bethesda, United States. In Nat Med, Nov 2015
T cells possess a unique mechanism of p38 mitogen-activated protein kinase (MAPK) activation downstream of T cell receptor (TCR) engagement through the phosphorylation of Tyr323 (pY323).
RAF inhibitors that evade paradoxical MAPK pathway activation.
Bollag et al., Berkeley, United States. In Nature, Nov 2015
Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-independent mitogen-activated protein kinase (MAPK) pathway signalling.
Shock wave treatment enhances endothelial proliferation via autocrine vascular endothelial growth factor.
Guo et al., Kunming, China. In Genet Mol Res, 2014
We also determined the mechanism underlying SW-induced the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) using western blotting.
Glucagon-like peptide-1 receptor agonists inhibit hepatic stellate cell activation by blocking the p38 MAPK signaling pathway.
Lu et al., Hangzhou, China. In Genet Mol Res, 2014
We investigated the effects of glucagon-like peptide-1 receptor (GLP-1R) agonists on p38 mitogen-activated protein kinase (MAPK) signaling during inhibition of hepatic stellate cell (HSC) activity.
Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.
González et al., Málaga, Spain. In Antioxidants (basel), 2014
UV radiation reduces cellular antioxidant status by generating reactive oxygen species (ROS), and the resultant oxidative stress alters signal transduction pathways such as the mitogen-activated protein kinase (MAPK), the nuclear factor-kappa beta (NF-κB)/p65, the janus kinase (JAK), signal transduction and activation of transcription (STAT) and the nuclear factor erythroid 2-related factor 2 (Nrf2).
ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
Hellman et al., San Francisco, United States. In J Biol Chem, 2012
observed that, although MEK1 negatively regulates TLR2 signaling in EC, MEK1 promotes TLR2 signaling in monocytes
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Pao et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2012
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.
Messersmith et al., Nashville, United States. In Lancet Oncol, 2012
Define the maximum tolerated dose and recommended phase 2 dose of MEK1/2 inhibitor trametinib and to assess its safety, pharmacokinetics, pharmacodynamics, and response rate in individuals with advanced solid tumours.
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.
Fecher et al., Houston, United States. In Lancet Oncol, 2012
Data show substantial clinical activity of MEK1/2 inhibitor trametinib in melanoma and suggest that MEK is a valid therapeutic target.
Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.
Sugatani et al., Shizuoka, Japan. In Biochim Biophys Acta, 2012
These results suggest that EGF is secreted from A549 cells by MMP and increases claudin-2 expression mediated via the activation of an EGFR/MEK/ERK pathway.
More papers using mitogen-activated protein kinase antibodies
Purification, Identification, and Cloning of Lysoplasmalogenase, the Enzyme That Catalyzes Hydrolysis of the Vinyl Ether Bond of Lysoplasmalogen*
Jurkowitz Marianne S. et al., In The Journal of Biological Chemistry, 2002
... The antibodies against MEK1/2 and cytochrome c oxidase were from Cell Signaling (catalogue no ...
Role of MAP kinase in tumor progression and invasion
Wang Yanhong et al., In BMC Medicine, 2002
... The MEK1/2 inhibitor U0126 was purchased from Cell Signaling Technologies Inc ...
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Sundan Anders et al., In European Journal of Haematology, 2002
... The Shp2 inhibitor NSC-87877 and the MEK1/2 inhibitors PD98059 and U126 were from Merck Chemicals Ltd (Nottingham, UK) ...
Tanis: a link between Type 2 Diabetes and Inflammation?
Stadler Krisztian, In PLoS ONE, 2001
... All other primary antibodies and MEK1/2 inhibitor PD95059 were from Cell Signaling.
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway
van der Goot F. Gisou et al., In The Journal of Cell Biology, 2000
... Antibodies against the COOH terminus of MEK1 were purchased from Santa Cruz Biotechnology, Inc.; the NH ...
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3
Kholodenko Boris N et al., In Molecular Systems Biology, 2000
... Antibodies against doubly phosphorylated p44/42 ERK, ERK, phospho-Akt (Ser473), Akt, phospho-MEK1/2 (Ser217/221), and MEK were purchased from Cell Signaling Technology Inc ...
Catalytically inactive human cathepsin D triggers fibroblast invasive growth
Liaudet-Coopman Emmanuelle et al., In The Journal of Cell Biology, 1998
... In some experiments, cells were pretreated for 6 h with the MEK1/2 inhibitor, U0126 (10 μM; Cell Signaling Technology, Inc.) and embedded ...
The NS5A/NS5 Proteins of Viruses from Three Genera of the Family Flaviviridae Are Phosphorylated by Associated Serine/Threonine Kinases.
Jang Sung Key, In PLoS ONE, 1997
... ERK-1 mAb was from BD Biosciences (San Jose, CA), MEK1/2 mAb from Cell Signaling Technology (Danvers, MA), HCV ...
Regulation of the cell cycle by focal adhesion kinase
Ossowski Liliana et al., In The Journal of Cell Biology, 1997
... Mek1 inhibitor PD98059 was from New England Biolabs Inc.; purified human single ...
Active MAP kinase in mitosislocalization at kinetochores and association with the motor protein CENP-E
Malhotra Vivek et al., In The Journal of Cell Biology, 1997
... The anti–COOH-terminal MEK1 was purchased from Santa Cruz Biotechnology.
Colitis causes bone loss in rats through suppression of bone formation.
Guerrero-Hernandez Agustin, In PLoS ONE, 1995
... PD98059, a MEK1 inhibitor, was purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection.
Oresic Matej, In PLoS ONE, 1995
... ERK phosphorylation was inhibited using the MEK1 inhibitor PD98059 (Cell Signaling Technology, Beverly MA, USA) ...
TGFβ3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
Hay Elizabeth D. et al., In The Journal of Cell Biology, 1994
... (7) 15 μM MEK1/2 inhibitor UO126 (Cell Signaling).
Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process
van der Goot F. Gisou et al., In The Journal of Cell Biology, 1993
... Anti-COOH-terminal MEK1 antibodies were obtained from Santa Cruz Biotechnology, Inc., anti-NH ...
Expression of epidermal growth factor, transforming growth factor-alpha and their receptor genes in human gastric carcinomas: implication for autocrine growth
Ellis L M et al., In British Journal of Cancer, 1989
... The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (MEK) 1/2 inhibitor U0126 and MEK1 inhibitor PD98059 were obtained from New England Biolabs Inc ...
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.
Xu Wenqing, In PLoS ONE, 1986
... Anti-phospho-ERK1/2, anti-phospho-MEK1/2, anti-total MEK1/2 antibodies and U0126 were obtained from Cell Signaling (Beverly, MA, USA); anti-total ...
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