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Mitogen-activated protein kinase kinase 3

Mitogen-Activated Protein Kinase 3, MKK3
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, MAPK, MKK6, JNK, V1a
Papers using Mitogen-Activated Protein Kinase 3 antibodies
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling
Supplier
Lowenstein Charles J. et al., In The Journal of Experimental Medicine, 2002
... ERK1/2, phospho-ERK1/2, phospho-MEK1/2, phospho-Raf, phospho-Elk-1, phospho-p90, p38, phospho-p38, JNK, phospho-JNK, phospho-Raf and acetyl-K, phospho-MKK3/6, and MKK3 were purchased from Cell Signaling Technology ...
Papers on Mitogen-Activated Protein Kinase 3
Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis.
New
Cao et al., Suzhou, China. In Biochem Pharmacol, Feb 2016
In addition, DHE markedly activated the stress response signaling pathway MEKK4-MKK3/6-p38-DDIT3, but significantly inhibited ERK signaling.
Suppression of phospho-p85α-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion.
New
Lin et al., Taiwan. In Mol Carcinog, Feb 2016
Treatment with TSWU-CD4 inhibited MMP-2 expression and cell invasion, which were restored by ectopic wild type (wt) p85α or a constitutively active form of MAPK kinase 3 (CA MKK3), CA MKK6, or CA p38α mitogen-activated protein kinase (MAPK).
Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts.
New
Zhao et al., Boston, United States. In Am J Physiol Cell Physiol, Feb 2016
The objective of this study is to elucidate the functional roles of MKK3 and Akt-1 in mediating exendin4-elicited protection in the infarcted hearts.
Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.
New
Swann et al., San Diego, United States. In Bioorg Med Chem Lett, Dec 2015
The Map Kinase Kinase isoforms 3 and 6 (MKK3 and MKK6) are responsible for the phosphorylation and activation of p38, and are hypothesized to play a key role in regulating this pathway without the redundancy seen in downstream effectors.
Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals.
Blaha et al., Czech Republic. In J Reprod Dev, 2014
All new evidence argues for a multiple roles of mitogen-activated protein kinase 3/1 (MAPK3/1) in the gonadotropin-induced ovulation processes.
Synergistic toxic interactions between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury.
Review
Wu et al., New York City, United States. In Adv Exp Med Biol, 2014
This activation of ASK-1 is followed by activation of the mitogen-activated kinase kinases MKK3/MKK6 and MKK4/MMK7 and subsequently p38 and JNK MAP kinases.
Role of caveolin-1 and caveolae signaling in endotoxemia and sepsis.
Review
Li et al., Jinan, China. In Life Sci, 2013
In this review, we present a number of studies addressing caveolae and sepsis and describe the signaling pathways involved, including the LPS-eNOS-TLR4-NFκB, MKK3/p38 MAPK, cPLA2/p38 MAPK, STAT3/NFκB and IL-1β-IL-1R1 pathways.
[Regulation of expression, function, and inflammatory responses of innate immune receptor Toll-like receptor-2 (TLR2) during inflammatory responses against infection].
Review
Shuto, Kumamoto, Japan. In Yakugaku Zasshi, 2012
We first showed that nontypeable Haemophilus influenzae (NTHi), an important human pathogen that exacerbates otitis media and chronic obstructive pulmonary diseases (COPD), induces inflammatory responses through activation of NF-κB via two distinct signals, NIK-IKKα/β-IκBα and MKK3/6-p38 pathways.
Translational control of NKT cell cytokine production by p38 MAPK.
GeneRIF
Boyson et al., Burlington, United States. In J Immunol, 2011
The p38 MAPK pathway transgene is dispensable for the development of natural killer (NK)T cells; however, NKT cell cytokine production and NKT-mediated liver damage are highly dependent on activation of this pathway.
Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy.
Review
Lim et al., Australia. In Am J Physiol Renal Physiol, 2011
These novel strains [ICAM-1-/-, CCL2-/-, MKK3-/-, osteopontin-/-, plasminogen activator inhibitor-1 (PAI-1)-/-, endothelial nitric oxide synthase-/-, SOD-Tg, rCAT-Tg] have provided valuable insights into the molecular mechanisms which promote diabetic renal injury.
Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.
GeneRIF
Sánchez-Prieto et al., Albacete, Spain. In Plos One, 2010
the balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC
Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancer.
GeneRIF
Souchelnytskyi et al., Stockholm, Sweden. In Proteomics Clin Appl, 2010
MAP2K3 is identified as a protein to promote senescence in human breast epithelial cells.
Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib.
GeneRIF
Parmar et al., Dallas, United States. In Leuk Lymphoma, 2009
Data provide evidence that p38 Map kinase (MAPK) pathway is activated leading to increased upregulation of mixed lineage kinase 3, MKK3/6, MSK1, and Mapkapk2, upon treatment of BCR/ABL expressing cells with dasatinib.
T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.
GeneRIF
Bender et al., New Haven, United States. In Plos One, 2009
LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade
Mirk/Dyrk1B in cancer.
Review
Friedman, Syracuse, United States. In J Cell Biochem, 2007
Mirk is activated by phosphorylation by the stress-activated SAPK kinases MKK3 and MKK6.
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Impact
Li et al., Rochester, United States. In Immunity, 2007
CYLD was highly induced by PLY, and it inhibited MKK3-p38 kinase-dependent expression of plasminogen activator inhibitor-1 (PAI-1) in lung, thereby potentiating ALI and mortality.
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.
Impact
Johnson et al., Chapel Hill, United States. In Nat Cell Biol, 2003
We have discovered a novel scaffold protein that binds to actin, the GTPase Rac, and the upstream kinases MEKK3 and MKK3 in the p38 MAPK phospho-relay module.
Different site, different splice.
Impact
Misteli, In Nat Cell Biol, 2000
The MKK3/6-p38 pathway has been found to induce the relocalization of premessenger-RNA splicing factors from the nucleus to the cytoplasm.
RAC1/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells.
Impact
Santoni et al., Roma, Italy. In Immunity, 2000
In addition, we identified some of the upstream events accompanying the beta1 integrin-mediated p38 MAPK activation, namely, the activation of the Rac guanine nucleotide exchange factor (GEF) p95 Vav, the small G protein Rac1, and the cytoplasmic kinases Pak1 and MKK3.
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Impact
Gotoh et al., Tokyo, Japan. In Science, 1997
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively.
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