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ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit

mitochondrial ATPase, mitochondrial ATPase 6
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2.[provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: ATPase, ACID, CAN, HAD, V1a
Papers on mitochondrial ATPase
Dimerization interface and dynamic properties of yeast IF1 revealed by Site-Directed Spin Labeling EPR spectroscopy.
New
Belle et al., Marseille, France. In Biochim Biophys Acta, Jan 2016
The mitochondrial ATPase inhibitor, IF1, regulates the activity of the mitochondrial ATP synthase.
The region from phenylalanine-28 to lysine-50 of a yeast mitochondrial ATPase inhibitor (IF1) forms an α-helix in solution.
New
Ichikawa et al., Ōsaka, Japan. In J Bioenerg Biomembr, Dec 2015
A mitochondrial ATPase inhibitor, IF1, is a 63 amino acid residue protein that regulates the activity of ATP synthase (F1Fo-ATPase).
Hints for panmixia in Scomberomorus commerson in Indian waters revealed by mitochondrial ATPase 6 and 8 genes.
New
Jena et al., Cochin, India. In Mitochondrial Dna, Sep 2015
The genetic stock structure of S. commerson distributed along the Indian waters was identified using mitochondrial ATPase 6 and 8 genes.
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.
New
Horn et al., Dundee, United Kingdom. In Proc Natl Acad Sci U S A, Aug 2015
Kinetoplastid parasites cause lethal diseases in humans and animals.
Induction of rat hepatic mitochondrial membrane permeability transition pore opening by leaf extract of Olax subscorpioidea.
New
Adebayo et al., Nigeria. In Pharmacognosy Res, Jun 2015
MEOS also significantly increased mitochondrial ATP hydrolysis by mitochondrial ATPase in all concentration of the extract used.
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Herrera González et al., Mexico. In Med Sci Monit, 2014
The objective of this work was to assess and compare the relative expression of mRNA of mitochondrial ATPase subunits between samples of thyroid cancer and benign nodules.
Mitobolites: the elixir of life.
Impact
Kapahi et al., Novato, United States. In Cell Metab, 2014
Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Impact
Paw et al., Boston, United States. In Nature, 2012
To investigate this we used zebrafish genetic screens and cloned mitochondrial ATPase inhibitory factor 1 (atpif1) from a zebrafish mutant with profound anaemia, pinotage (pnt (tq209)).
ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression.
Review
Rousseau et al., Grenoble, France. In J Bioenerg Biomembr, 2012
ATAD3 (ATPase family AAA Domain-containing protein 3) is a mitochondrial membrane bound ATPase whose function has not yet been discovered but its role is essential for embryonic development.
[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].
Review
Rousseau et al., Grenoble, France. In Med Sci (paris), 2011
ATAD3 (ATPase family AAA domain-containing protein 3) is a mitochondrial membrane bound ATPase whose function has not yet been discovered but its role is essential for the embryonic development.
Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c.
GeneRIF
Houstek et al., Praha, Czech Republic. In Biochim Biophys Acta, 2010
the epsilon subunit is essential for the assembly of F1 and plays an important role in the incorporation of the hydrophobic subunit c into the F1-c oligomer rotor of the mitochondrial ATP synthase complex
Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells.
GeneRIF
Park et al., Seoul, South Korea. In Cancer Sci, 2008
Galectin 3 co-localized with ATP synthase in the inner membrane of mitochondria and had an inhibitory effect on ATP synthase in human colon cancer cells.
Cytochrome c oxidase biogenesis: new levels of regulation.
Review
Barrientos et al., Miami, United States. In Iubmb Life, 2008
For example, COX assembly and stability of the fully assembled enzyme depend on the presence in the mitochondrial compartments of two partners of the oxidative phosphorylation system, the mobile electron carrier cytochrome c and the mitochondrial ATPase.
Linking mitochondrial function to diabetes mellitus: an animal's tale.
Review
Berdanier, United States. In Am J Physiol Cell Physiol, 2007
This rat has a mutated mitochondrial ATPase 6 gene.
Citicoline: pharmacological and clinical review, 2006 update.
Review
Lorenzo et al., Barcelona, Spain. In Methods Find Exp Clin Pharmacol, 2006
In addition, citicoline has been shown to restore the activity of mitochondrial ATPase and membrane Na+/K+ATPase, to inhibit activation of certain phospholipases, and to accelerate reabsorption of cerebral edema in various experimental models.
Mitochondrial DNA sequences in the nuclear genome of a locust.
Impact
Wyatt et al., In Nature, 1983
However, evidence at the DNA sequence level for gene transfer between these organelles has so far been limited to a single example, the demonstration that a mitochondrial ATPase subunit gene of Neurospora crassa has an homologous partner in the nuclear genome.
Assembly of the mitochondrial membrane system: sequence analysis of a yeast mitochondrial ATPase gene containing the oli-2 and oli-4 loci.
Impact
Tzagoloff et al., In Cell, 1980
The mitochondrial DNA (mtDNA) segments of several rho- mutants carrying the oli-2, oli-4 and pho-1 loci have been sequenced.
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