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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Centromere protein I

Mis6, CENP-I, LRPR1
The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gli, CENP-C, CENP-H, Histone, CAN
Papers on Mis6
CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
New
Masumoto et al., Nagoya, Japan. In J Cell Sci, Jan 2016
Furthermore, we found that CENP-I can also recruit M18BP1 and, as a consequence, enhances M18BP1 assembly on centromeres in the downstream of CENP-C.
Inner Kinetochore Protein Interactions with Regional Centromeres of Fission Yeast.
New
Henikoff et al., Seattle, United States. In Genetics, Oct 2015
Inner kinetochore proteins CENP-A, CENP-C, CENP-T, CENP-I, and Scm3 are highly enriched throughout the central domain except at tRNA genes, with no evidence for preferred kinetochore assembly sites.
The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.
New
Desai et al., San Diego, United States. In Curr Biol, Mar 2015
N-tail mutants specifically reduced localization of the CCAN proteins Cnp20/CENP-T and Mis6/CENP-I, but not Cnp3/CENP-C.
CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.
Stukenberg et al., Charlottesville, United States. In J Cell Biol, 2014
Here we demonstrate that the centromere protein CENP-I is required to generate a stable association of RZZ and Mad1 with kinetochores.
The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A.
Sato et al., Tokyo, Japan. In Plos One, 2013
We also found that the inner kinetochore proteins Mis6/CENP-I and Cnp1/CENP-A were delocalized from kinetochores in the kis1 cells and that kinetochore-microtubule attachment was defective.
The pseudo GTPase CENP-M drives human kinetochore assembly.
Musacchio et al., Milano, Italy. In Elife, 2013
We show that CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches.
The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly.
Fukagawa et al., Mishima, Japan. In J Cell Biol, 2013
Ectopic targeting of full-length HJURP, CENP-C, CENP-I, or the CENP-C C terminus generated engineered kinetochores containing major kinetochore components, including CENP-A.
Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases.
GeneRIF
Valdivia et al., Cadiz, Spain. In Clin Chim Acta, 2011
demonstrates that CENPI, a centromere protein that localizes to the inner kinetochore structure, is a human autoantigen. The significance of anti-CENPI autoantibodies could be relevant in scleroderma patients as a marker for autoimmune liver disease
The ABCs of CENPs.
Review
Fukagawa et al., Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase.
Review
Dasso et al., Bethesda, United States. In Cell Cycle, 2010
This gross mislocalization of IKPs is due to proteolytic degradation of CENP-I and CENP-H via the SUMO targeted Ubiquitin Ligase (STUbL) pathway.
Molecular control of kinetochore-microtubule dynamics and chromosome oscillations.
Impact
Meraldi et al., Z├╝rich, Switzerland. In Nat Cell Biol, 2010
We also show that the abundance of the CENP-A NAC/CAD subunits CENP-H and CENP-I dynamically change on individual sister kinetochores in vivo, because they preferentially bind the sister kinetochore attached to growing microtubules, and that one other subunit, CENP-Q, binds microtubules in vitro.
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.
Impact
Straight et al., Palo Alto, United States. In Nat Cell Biol, 2009
Mutations in CENP-N that reduced its affinity for CENP-A nucleosomes caused defects in CENP-N localization and had dominant effects on the recruitment of CENP-H, CENP-I and CENP-K to centromeres.
KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.
GeneRIF
Desai et al., San Diego, United States. In Mol Biol Cell, 2008
the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins.
Early human use of marine resources and pigment in South Africa during the Middle Pleistocene.
Impact
Williams et al., Tempe, United States. In Nature, 2007
From 195-130 kyr ago, the world was in a fluctuating but predominantly glacial stage (marine isotope stage MIS6); much of Africa was cooler and drier, and dated archaeological sites are rare.
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.
Impact
GeneRIF
Fukagawa et al., Mishima, Japan. In Nat Cell Biol, 2006
The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres.
Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles.
GeneRIF
Takahashi et al., Kurume, Japan. In Mol Biol Cell, 2005
Mis6-complex, in collaboration with the Nuf2-complex, monitors the spindle-kinetochore attachment state and acts as a platform for Mad2 to accumulate at unattached kinetochores
Building the centromere: from foundation proteins to 3D organization.
Review
Choo et al., Melbourne, Australia. In Trends Cell Biol, 2004
CENP-A, Mis12, CENP-C, CENP-H and CENP-I localize to a core domain of centromeric chromatin.
Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis.
Impact
Yen et al., Philadelphia, United States. In Nat Cell Biol, 2003
Here we report that human CENP-I, a constitutive protein of the kinetochore that shares limited similarity with Mis6 of Schizosaccharomyces pombe, is required for the localization of CENP-F and the checkpoint proteins MAD1 and MAD2 to kinetochores.
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