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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MIS12, MIND kinetochore complex component, homolog

Mis12, hMis12, Mtw1, Mtw1p
Top mentioned proteins: HEC, Histone, Gli, Bub1, CENP-C
Papers on Mis12
Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.
Kops et al., Utrecht, Netherlands. In Chromosoma, 2014
Using rapamycin-induced heterodimerization of FKBP-MAD1 to FRB-MIS12 and live monitoring of cyclin B1 degradation, we show that timed relocalization of MAD1 during metaphase can stop cyclin B1 degradation without affecting chromosome-spindle attachments.
Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells.
Herrera et al., Mexico. In Cell Div, 2013
HP1 might participate in recruiting and directing Mis12 to the centromere during interphase, and HP1 disruption or abrogation might lead to the loss of Mis12 incorporation into the kinetochore.
Kinetochore KMN network gene CASC5 mutated in primary microcephaly.
Abramowicz et al., Brussels, Belgium. In Hum Mol Genet, 2013
CASC5 binds BUB1, BUBR1, ZWINT-1 and interestingly it binds to MIS12 through a protein domain which is truncated by the mutation.
Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules.
Yao et al., Hefei, China. In J Biol Chem, 2012
However, it remains elusive how kinetochore core microtubule binding activity KMN (KNL1-MIS12-NDC80) regulates microtubule plus-end dynamics.
Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
Liu et al., West Lafayette, United States. In Mol Cell Biol, 2012
This phosphorylation event enhances the association of the Hsp90-Sgt1 chaperone with the MIS12 complex to stabilize this complex at the kinetochores and thus coordinates the recruitment of the NDC80 complex to form efficient microtubule-binding sites.
Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
Impact
GeneRIF
De Wulf et al., Milano, Italy. In Nat Cell Biol, 2012
Cnn1 regulates KMN (KNL1, MIS12 and NDC80 activity in a spatiotemporal manner by inhibiting the interaction between its complexes
Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.
Ishizaka et al., Tokyo, Japan. In J Cell Biol, 2011
In Vpr-expressing cells, hRad21, hSgo1, and hMis12, which are crucial for proper chromosome segregation, were displaced from the centromeres of mitotic chromosomes, resulting in premature chromatid separation (PCS).
Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana.
Chan et al., Davis, United States. In Plos Genet, 2011
Loss of the GFP-tailswap CENH3 variant in meiosis affects recruitment of the essential kinetochore protein MIS12.
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
Chan et al., Edmonton, Canada. In Biochem J, 2011
In addition to hZw10, we have found that hZwint-1 interacts with components of the conserved Ndc80 and Mis12 complexes in yeast two-hybrid and GST (glutathione transferase) pull-down assays.
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
GeneRIF
Musacchio et al., Milano, Italy. In Curr Biol, 2011
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.
Yanagida et al., Kyoto, Japan. In Mol Cell Biol, 2011
Taken together, these results indicate that blinkin functions to connect Bub1 and BubR1 with the hMis12, Ndc80, and Zwint-1 complexes, and disruption of this connection may lead to tumorigenesis.
Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex.
Westermann et al., Vienna, Austria. In J Mol Biol, 2011
Among the biochemically distinct kinetochore complexes, the conserved four-protein Mtw1 complex is a central part of the kinetochore in all organisms.
Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability.
Larionov et al., Bethesda, United States. In Plos One, 2010
This analysis revealed that 17 genes encoding the constitutive centromere associated network of the kinetochore core (the CCAN complex) plus four additional genes with established importance in kinetochore maintenance (CENPE, CENPF, INCENP, and MIS12) exhibit similar patterns of expression in the NCI-60, suggesting a mechanism for co-regulated transcription of these genes which is maintained despite the multiple genetic and epigenetic rearrangements accumulated in these cells (such as variations in DNA copy number and karyotypic complexity).
Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites.
GeneRIF
Kaplan et al., Davis, United States. In J Cell Biol, 2010
These findings support a novel role for Hsp90-Sgt1 chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly.
Fused sister kinetochores initiate the reductional division in meiosis I.
Impact
Dawe et al., Athens, United States. In Nat Cell Biol, 2009
Here we pursue this issue using knockdown mutants of the core kinetochore protein MIS12 (minichromosome instability 12).
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.
GeneRIF
Desai et al., San Diego, United States. In J Cell Biol, 2006
These results indicate that a four-subunit Mis12 complex plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly.
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
Impact
Yanagida et al., Kyoto, Japan. In Nat Cell Biol, 2004
Mis12-Mtw1 is a conserved, essential kinetochore protein family.
Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway.
GeneRIF
Yanagida et al., Kyoto, Japan. In J Cell Biol, 2003
hMIS12 has a role in mitosis and localizes at kinetochores
Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast.
Impact
Yanagida et al., Kyoto, Japan. In Cell, 2000
Mtw1p, a homolog of fission yeast Mis12 required for biorientation, locates at the centromeres in an Ndc10p-dependent manner.
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