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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Anti-Mullerian hormone receptor, type II

MIS type II receptor, Amhr2, MISRII, AMH type II receptor, AMHR, MISIIR
This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: AMH, AGE, HAD, CAN, TGF-beta
Papers on MIS type II receptor
Anti-Proliferative and Apoptotic Activities of Müllerian Inhibiting Substance Combined with Calcitriol in Ovarian Cancer Cell Lines.
Kim et al., Wŏnju, South Korea. In Yonsei Med J, Jan 2016
RESULTS: The cells showed specific staining for the MIS type II receptor.
Polymorphisms of anti-Müllerian hormone signaling pathway in healthy Singapore women: population differences, endocrine effects and reproductive outcomes.
Yong et al., Singapore, Singapore. In Gynecol Endocrinol, Jan 2016
The allele frequencies of the AMH Ile(49)Ser and AMHR2 -482A > G polymorphisms were analyzed in relation to female reproductive hormone levels, ovarian parameters, menstrual cycle lengths and pregnancy outcomes.
Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?
Cupp et al., Lincoln, United States. In J Endocrinol, Nov 2015
However, in vivo models using mice which selectively eliminated all VEGFA isoforms: in Sertoli and germ cells (pDmrt1-Cre;Vegfa(-/-)); Sertoli and Leydig cells (Amhr2-Cre;Vegfa(-/-)) or Sertoli cells (Amh-Cre;Vegfa(-/-) and Sry-Cre;Vegfa(-/-)) displayed testes with observably normal cords and vasculature at postnatal day 0 and onwards.
Molecular changes in the equine follicle in relation to variations in antral follicle count and anti-Müllerian hormone concentrations.
Scoggin et al., Lexington, United States. In Equine Vet J, Oct 2015
RESULTS: Within growing follicles, the expression of AMH, AMHR2, ESR2 and INHA in granulosa cells was positively correlated with AFC and plasma AMH concentrations.
Immuno-stimultory/regulatory gene expression patterns in advanced ovarian cancer.
Odunsi et al., Buffalo, United States. In Genes Cancer, Sep 2015
Three of these (MAGEA8, MPL, AMHR2) were validated and one (WT1) could not be evaluated.
AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer.
Donahoe et al., Boston, United States. In Proc Natl Acad Sci U S A, Sep 2015
Finally, we tested the frequency of MIS type II receptor expression in a tissue microarray of serous ovarian tumors by immunohistochemistry and found that 88% of patients bear tumors that express the receptor.
Expression of anti-Müllerian hormone and its type II receptor in germ cells of maturing rat testis.
Yamano et al., Japan. In Endocr J, 2014
This work aimed to clarify the expression and roles of anti-Müllerian hormone (AMH) and its type 2 receptor (AMHR2) in seminiferous tubules of maturing rat testes.
Attenuated AMH signaling pathway plays an important role in the pathogenesis of ovarian hyperstimulation syndrome.
Zhao et al., Wuhan, China. In Am J Transl Res, 2014
Although the mRNA expression level of AMH was hardly detectable in GCs, the mRNA expression level of AMHR2 in GCs from OHSS patients was significantly lower than the AMHR2 mRNA expression level in the control population.
Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II.
Tuohy et al., Cleveland, United States. In J Immunol Res, 2014
Anti-Müllerian hormone receptor, type II (AMHR2), is a differentiation protein expressed in 90% of primary epithelial ovarian carcinomas (EOCs), the most deadly gynecologic malignancy.
Possible involvement of single nucleotide polymorphisms in anti-Müllerian hormone signaling pathway in the pathogenesis of early OHSS in Han Chinese women.
Zhao et al., Wuhan, China. In Int J Clin Exp Pathol, 2014
To investigate the possible relationship between single nucleotide polymorphisms (SNPs) in the anti-Müllerian hormone (AMH) signaling pathway and the incidence of early OHSS, the genomic DNA was isolated from peripheral blood leukocytes of 122 participants (62 patients with early OHSS and 60 patients without OHSS who underwent IVF/ICSI), and SNPs of the AMH and AMHR2 exons were detected directly.
[What's new in 2014 about anti-Müllerian hormone?].
Grynberg et al., Bondy, France. In J Gynecol Obstet Biol Reprod (paris), 2014
Since then, AMH has been purified, its gene and specific receptor, AMHR-II have been cloned.
Novel sex-determining genes in fish and sex chromosome evolution.
Hamaguchi et al., Hamamatsu, Japan. In Dev Dyn, 2013
These include amhy in the Patagonian pejerrey, Gsdf in Oryzias luzonensis, Amhr2 in fugu and sdY in rainbow trout.
Mutations of the AMH type II receptor in two extended families with persistent Müllerian duct syndrome: lack of phenotype/genotype correlation.
Josso et al., Dhahran, Saudi Arabia. In Horm Res Paediatr, 2011
the diversity of clinical symptoms within sibship and lack of correlation between development of Mullerian derivatives and severity of molecular defects suggest highly variable penetrance of abnormal alleles
Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta.
Cate et al., Clamart, France. In Mol Endocrinol, 2010
AMH thus exemplifies a new mechanism for receptor engagement in which interaction with the type II receptor promotes pro-region dissociation to generate mature ligand.
Association study of AMH and AMHRII polymorphisms with unexplained infertility.
Clementi et al., Padova, Italy. In Fertil Steril, 2010
Genetic variants of AMH and AMHRII genes seem to be associated with infertility.
Association study of four key folliculogenesis genes in polycystic ovary syndrome.
Goodarzi et al., Los Angeles, United States. In Bjog, 2010
data demonstrate that polymorphisms in major folliculogenesis genes, GDF9, BMP15, AMH, and AMHR2, are not associated with polycystic ovary syndrome susceptibility.
Anti-Müllerian hormone (AMH): regulator and marker of ovarian function.
Visser et al., Rotterdam, Netherlands. In Ann Endocrinol (paris), 2010
Association studies of common variants of AMHRII suggests that antimullerian hormone may regulate the primordial graafian follicle recruitment.
The Müllerian duct: recent insights into its development and regression.
Englert et al., Jena, Germany. In Sex Dev, 2006
Besides AMH and its specific type II receptor AMHR2 two different type I receptors as well as different SMAD family members have been shown to be involved in the AMH signaling cascade.
AMH and AMH receptor defects in persistent Müllerian duct syndrome.
Picard et al., Clamart, France. In Hum Reprod Update, 2005
Mutations of the AMH and AMH receptor type II (AMHR-II) genes lead to persistence of the uterus and Fallopian tubes in males.
Requirement of Bmpr1a for Müllerian duct regression during male sexual development.
Behringer et al., Houston, United States. In Nat Genet, 2002
Amh induces regression by binding to a specific type II receptor (Amhr2) expressed in the mesenchyme surrounding the ductal epithelium.
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