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Ras homolog gene family, member T2

Miro-2, Rasl
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: Arht1, Rhodopsin, RhoC, Actin, RhoA
Papers on Miro-2
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
Impact
GeneRIF
Schwarz et al., Boston, United States. In Cell, 2011
Study shows that both PINK1 and Parkin halt mitochondrial movement; PINK1 phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin- and proteasome-dependent pathway.
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
Rempe et al., Rochester, United States. In J Cell Biol, 2009
Interestingly, HUMMR interacts with Miro-1 and Miro-2, mitochondrial proteins that are critical for mediating mitochondrial transport.
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.
GeneRIF
Hajnóczky et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2009
Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.
GeneRIF
Aspenström et al., Uppsala, Sweden. In Biochem Biophys Res Commun, 2006
Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.
Rho GTPases have diverse effects on the organization of the actin filament system.
Saras et al., Uppsala, Sweden. In Biochem J, 2004
None of the RhoBTB or Miro GTPases had any major influence on the organization of the actin filament system; instead, RhoBTB1 and RhoBTB2 were present in vesicular structures, and Miro-1 and Miro-2 were present in mitochondria.
Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis.
Aspenström et al., Uppsala, Sweden. In J Biol Chem, 2003
These proteins, which were called Miro-1 and Miro-2 (for mitochondrial Rho), have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs.
Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis.
DiNardo et al., New York City, United States. In Development, 1997
In a screen for additional mutations affecting Engrailed cell fate, we identified anterior open/yan, a gene encoding an inhibitory ETS-domain transcription factor that is negatively regulated by the Rasl-MAP kinase signaling cascade.
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