CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology.
Leuven, Belgium. In J Leukoc Biol, Feb 2016
A large number of human chemokines, including CXCL2, CXCL6, CXCL9, CXCL10, CXCL11, CXCL12, CCL3L1, CCL4, CCL5, CCL11, CCL14, and CCL22, are cleaved by CD26; however, the efficiency is clearly influenced by the amino acids surrounding the cleavage site and although not yet proven, potentially affected by the chemokine concentration and interactions with third molecules.
[Roles of transient receptor potential melastatin 2 expressed on immune cells in neuropathic pain].
Kyoto, Japan. In Yakugaku Zasshi, 2013
In peripheral nerve injury-induced neuropathic pain models, TRPM2 deficiency diminished infiltration of neutrophils mediated through CXCL2 production from macrophages around the injured peripheral nerve and activation of spinal microglia, suggesting that TRPM2 expressed on macrophages and microglia aggravates peripheral and spinal pronociceptive inflammatory responses.
Nutritionally mediated oxidative stress and inflammation.
New York City, United States. In Oxid Med Cell Longev, 2012
Specifically the upregulation of CCL2/MCP-1, CCL3/MIP-1 α , CCL4/MIP-1 β , CXCL2/MIP-2 α , and CXCL3/MIP-2 β is noted because these changes have been observed in both adipocytes and PBMC of obese humans.
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.
Philadelphia, United States. In Immunity, 2010
CXCL5 increased the plasma concentrations of CXCL1 and CXCL2 in part through inhibiting chemokine scavenging, impairing chemokine gradients and desensitizing CXCR2, which led to decreased neutrophil influx to the lung, increased lung bacterial burden and mortality in an Escherichia coli pneumonia model.