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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MLX interacting protein-like

Mio, ChREBP, MLXIPL
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, Sterol Regulatory Element Binding Protein 1, CAN, V1a
Papers using Mio antibodies
Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin.
Supplier
Schneider-Stock Regine, In PLoS ONE, 2010
... ChREBP antibody was purchased from Novus Biologicals, (Littleton, CO) ...
Papers on Mio
Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota.
New
Patterson et al., State College, United States. In J Proteome Res, Feb 2016
Hepatic gene expression was significantly altered as demonstrated by an increase in Pepck and G6pase and a decrease in Hnf4a, ChREBP, Fabp1, and Cd36 mRNAs.
Nuclear Retention of mRNA in Mammalian Tissues.
New
Itzkovitz et al., Israel. In Cell Rep, Jan 2016
These include genes such as the transcription factor ChREBP, Nlrp6, Glucokinase, and Glucagon receptor.
Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice.
New
Shen et al., Hefei, China. In Parasit Vectors, Dec 2015
The inflammation was monitored by recording weight change, stool character and bleeding, colon length, macroscopic score (MAO), microscopic score (MIO), myeloperoxidase activity (MPO) and disease activity index (DAI).
Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers.
New
Chan et al., East Lansing, United States. In Sci Rep, Dec 2015
Our association analysis revealed a uniform pattern of Warburg effect mutations influencing prognosis across all tumor types, while copy number alterations in the electron transport chain gene SCO2, fatty acid uptake (CAV1, CD36) and lipogenesis (PPARA, PPARD, MLXIPL) genes were enriched in metastatic tumors.
Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism.
Review
New
Postic et al., Paris, France. In Physiology (bethesda), Nov 2015
Since glucose is the principal energy source for most cells, many organisms have evolved numerous and sophisticated mechanisms to sense glucose and respond to it appropriately.
Transcriptional regulation of hepatic lipogenesis.
Review
New
Impact
Sul et al., Berkeley, United States. In Nat Rev Mol Cell Biol, Nov 2015
Transcription factors, such as upstream stimulatory factors (USFs), sterol regulatory element-binding protein 1C (SREBP1C), liver X receptors (LXRs) and carbohydrate-responsive element-binding protein (ChREBP) have crucial roles in this process.
The role of TRIB1 in lipid metabolism; from genetics to pathways.
Review
New
Nakayama et al., Tochigi, Japan. In Biochem Soc Trans, Nov 2015
Recently, carbohydrate-responsive element-binding protein (ChREBP) emerged as a novel binding partner of TRIB1.
Benefits of the Mediterranean Diet: Insights From the PREDIMED Study.
Review
New
PREDIMED INVESTIGATORS et al., Pamplona, Spain. In Prog Cardiovasc Dis, Jul 2015
In nutrigenomic studies beneficial effects of the intervention with MedDiets showed interactions with several genetic variants (TCF7L2, APOA2, MLXIPL, LPL, FTO, M4CR, COX-2, GCKR and SERPINE1) with respect to intermediate and final phenotypes.
Diet rich in Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice.
Liu et al., Beijing, China. In Nutr Metab (lond), 2014
In analyzing hepatic gene expression pattern it was found that TG synthesis related genes, such as carbohydrate response element binding protein (ChREBP), stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (Fas) were upregulated in SKO mice compared to WT mice but were significantly decreased in SKO mice on DHA/EPA diet.
Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.
Forrest et al., Yokohama, Japan. In Front Genet, 2014
In the core TRN (i.e., TF-TF only), NEUROD1 directly transcriptionally activates the pancreatic TFs HSF4, INSM1, MLXIPL, MYT1, NKX6-3, ONECUT2, PAX4, PROX1, RFX6, ST18, DACH1, and SHOX2, while LMX1A directly transcriptionally activates DACH1, SHOX2, PAX6, and PDX1.
Discovery of Novel Anti-Diabetic Drugs by Targeting Lipid Metabolism.
Review
Ye et al., Melbourne, Australia. In Curr Drug Targets, 2014
We will particularly focus on AMPK, SIRT1, PGC-1α, SREBP-1c, ChREBP, ACC, PPARs and HSPs which either stimulate in fatty acid oxidation (energy expenditure) or inhibit de novo lipogenesis.
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.
Impact
Tontonoz et al., Los Angeles, United States. In Cell Metab, 2013
Impaired hepatic lipogenesis in LOKO mice is accompanied by reciprocal increases in adipose lipid storage, reflecting tissue-selective effects on the SREBP, PPARγ, and ChREBP lipogenic pathways.
ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.
GeneRIF
Scott et al., Pittsburgh, United States. In Diabetes, 2012
Depletion of ChREBP decreased glucose-stimulated proliferation in beta-cells isolated from ChREBP(-/-) mice, in INS-1-derived 832/13 cells, and in primary rat and human beta-cells
Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.
Impact
Postic et al., Paris, France. In Cell Metab, 2012
The ChREBP transcription factor is regulated by glucose and plays a role in insulin sensitivity, but the mechanism underlying these effects remains unclear.
Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity.
GeneRIF
Chan et al., Houston, United States. In Diabetologia, 2012
Data indicate that ChREBP is a key transcription factor that mediates many of the hyperglycaemia-induced activations in a gene expression programme that underlies beta cell glucotoxicity at the molecular, cellular and whole animal levels.
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.
GeneRIF
Postic et al., Paris, France. In J Clin Invest, 2012
ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conversion of saturated fatty acids (SFAs) into MUFAs
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
Impact
GeneRIF
Kahn et al., Boston, United States. In Nature, 2012
adipose ChREBP is a major determinant of adipose tissue fatty acid synthesis and systemic insulin sensitivity
Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells.
GeneRIF
Leclerc et al., London, United Kingdom. In Diabetes, 2012
sorcin retains ChREBP in the cytosol at low glucose concentrations and may act as a Ca(2+) sensor for glucose-induced nuclear translocation and the activation of ChREBP-dependent genes.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Impact
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
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