Papers on
mineralocorticoid receptor
Corticosteroids and the retina: a role for the mineralocorticoid receptor.Zhao et al., Paris, France. In Curr Opin Neurol, Feb 2016
RECENT FINDINGS: Recently, the over activation of the mineralocorticoid receptor (MR) pathway has been shown to cause fluid accumulation in the retina, choroidal vasodilation, and to promote retinal neovascularization in hypoxic conditions.
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.Hummler et al., Lausanne, Switzerland. In Pflugers Arch, Feb 2016
Germline loss-of-function mutations of the mineralocorticoid receptor (MR) in humans and in mice lead to the "renal" form of type 1 pseudohypoaldosteronism (PHA-1), a case of aldosterone resistance characterized by salt wasting, dehydration, failure to thrive, hyperkalemia, and metabolic acidosis.
Aldosterone alters the chromatin structure of the murine endothelin-1 gene.Wingo et al., Gainesville, United States. In Life Sci, Feb 2016
SIGNIFICANCE: The evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene.
Up-Regulation of FGF23 Release by Aldosterone.Lang et al., Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
Aldosterone further increased Fgf23 transcript levels in UMR106 cells, an effect reversed by mineralocorticoid receptor blockers spironolactone and eplerenone, SGK1 inhibitor EMD638683, NFκB-inhibitor withaferin A, and Ca(2+) channel blocker YM58483.
The Glucocorticoid Receptor: Cause or Cure for Obesity?Hinds et al., Toledo, Philippines. In Am J Physiol Endocrinol Metab, Jan 2016
Alternative mechanisms are then proposed for the lipogenic actions of GCs, including induction of GC resistance by the GRβ isoform, and promotion of lipogenesis by GC activation of the mineralocorticoid receptor (MR).
Reversing methanogenesis to capture methane for liquid biofuel precursors.Wood et al., United States. In Microb Cell Fact, Dec 2015
To capture methane, we cloned the enzyme methyl-coenzyme M reductase (Mcr) from an unculturable organism, anaerobic methanotrophic archaeal population 1 (ANME-1) from a Black Sea mat, into M. acetivorans to effectively run methanogenesis in reverse.
Mineralocorticoids in the heart and vasculature: new insights for old hormones.Hein et al., Freiburg, Germany. In Annu Rev Pharmacol Toxicol, 2014
Experimental studies using cell type-specific gene targeting of the mineralocorticoid receptor (MR) gene in mice have revealed the importance of extrarenal aldosterone signaling in cardiac myocytes, endothelial cells, vascular smooth cells, and macrophages.
Resistant hypertension: a review of diagnosis and management.Vongpatanasin, Dallas, United States. In Jama, 2014
An increasing body of evidence has suggested benefits of mineralocorticoid receptor antagonists, such as eplerenone and spironolactone, in improving blood pressure control in patients with resistant hypertension, regardless of circulating aldosterone levels.