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Nuclear receptor subfamily 3, group C, member 2

mineralocorticoid receptor, MLR, MCR, aldosterone receptor
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Angiotensin II, CAN, HAD, V1a, Renin
Papers on mineralocorticoid receptor
Mineralocorticoid Receptor Antagonists in End-Stage Renal Disease: Efficacy and Safety.
New
Bomback, New York City, United States. In Blood Purif, Feb 2016
UNASSIGNED: Mineralocorticoid receptor antagonists (MRAs) that block aldosterone's effects on both epithelial and non-epithelial receptors have become a mainstay of therapy for chronic heart failure.
Aldosterone alters the chromatin structure of the murine endothelin-1 gene.
New
Wingo et al., Gainesville, United States. In Life Sci, Feb 2016
SIGNIFICANCE: The evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene.
Therapy modifications during hospitalization in patients with chronic heart failure.
New
Lainscak et al., Ljubljana, Slovenia. In Eur J Intern Med, Feb 2016
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists were prescribed to 78%, 58% and 20% of patients on admission and 72%, 65% and 23% at discharge, respectively.
Up-Regulation of FGF23 Release by Aldosterone.
New
Lang et al., Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
Aldosterone further increased Fgf23 transcript levels in UMR106 cells, an effect reversed by mineralocorticoid receptor blockers spironolactone and eplerenone, SGK1 inhibitor EMD638683, NFκB-inhibitor withaferin A, and Ca(2+) channel blocker YM58483.
Emerging Roles of the Mineralocorticoid Receptor in Pathology: Toward New Paradigms in Clinical Pharmacology.
Review
New
Impact
Farman et al., Paris, France. In Pharmacol Rev, Jan 2016
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators of hormone-regulated renal sodium reabsorption.
Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease.
Review
New
Schmieder et al., Germany. In Eur J Heart Fail, Jan 2016
Pharmaceutical antagonism of the mineralocorticoid receptor (MR) can protect against organ damage caused by elevated aldosterone levels in patients experiencing heart failure (HF), chronic kidney disease (CKD), primary aldosteronism, and hypertension.
The Glucocorticoid Receptor: Cause or Cure for Obesity?
Review
New
Hinds et al., Toledo, Philippines. In Am J Physiol Endocrinol Metab, Jan 2016
Alternative mechanisms are then proposed for the lipogenic actions of GCs, including induction of GC resistance by the GRβ isoform, and promotion of lipogenesis by GC activation of the mineralocorticoid receptor (MR).
Reversing methanogenesis to capture methane for liquid biofuel precursors.
New
Wood et al., United States. In Microb Cell Fact, Dec 2015
To capture methane, we cloned the enzyme methyl-coenzyme M reductase (Mcr) from an unculturable organism, anaerobic methanotrophic archaeal population 1 (ANME-1) from a Black Sea mat, into M. acetivorans to effectively run methanogenesis in reverse.
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages.
New
Hu et al., Shanghai, China. In Plos One, Dec 2015
Eplerenone, a mineralocorticoid receptor (MR) antagonist, almost completely blocked Aldo-induced C18 ceramide production and HUVEC damages.
Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.
New
Impact
Mineralocorticoid Receptor Antagonist Tolerability Study–Diabetic Nephropathy (ARTS-DN) Study Group et al., Hong Kong, Hong Kong. In Jama, Oct 2015
IMPORTANCE: Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events.
Mineralocorticoids in the heart and vasculature: new insights for old hormones.
Review
Impact
Hein et al., Freiburg, Germany. In Annu Rev Pharmacol Toxicol, 2014
Experimental studies using cell type-specific gene targeting of the mineralocorticoid receptor (MR) gene in mice have revealed the importance of extrarenal aldosterone signaling in cardiac myocytes, endothelial cells, vascular smooth cells, and macrophages.
Mineralocorticoid Receptor Antagonists Therapy in Resistant Hypertension: Time to Implement Guidelines!
Review
Rossi et al., Padova, Italy. In Front Cardiovasc Med, 2014
Notwithstanding a complex pathogenesis, an abundance of data suggests a key contribution for the mineralocorticoid receptor (MR) in RH, thus fostering a potential role for its antagonists in RH.
[In Process Citation].
Review
Wängberg et al., Göteborg, Sweden. In Lakartidningen, 2014
An effective treatment is available for patients with primary aldosteronism, with mineralocorticoid receptor antagonists in bilateral, and minimal invasive adrenal surgery in unilateral disease, which emphasizes the importance of early detection, adequate diagnostic work-up and treatment.
Resistant hypertension: a review of diagnosis and management.
Review
Impact
Vongpatanasin, Dallas, United States. In Jama, 2014
An increasing body of evidence has suggested benefits of mineralocorticoid receptor antagonists, such as eplerenone and spironolactone, in improving blood pressure control in patients with resistant hypertension, regardless of circulating aldosterone levels.
Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia.
Impact
Lifton et al., New Haven, United States. In Cell Metab, 2013
The mineralocorticoid receptor (MR) is normally activated by aldosterone, which is produced in both volume depletion and hyperkalemia, states that require different homeostatic responses.
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.
Impact
GeneRIF
Jaffe et al., Boston, United States. In Nat Med, 2012
M<ice with smooth muscle cell-specific deficiency of the mineralocorticoid receptor have decreased blood pressure as they age without defects in renal sodium handling or vascular structure.
Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis.
GeneRIF
Young et al., Australia. In Endocrinology, 2012
macrophage MR are necessary for the translation of inflammation and oxidative stress into interstitial and perivascular fibrosis after NO deficiency, even when plasma aldosterone is not elevated
Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only.
GeneRIF
Yamamoto et al., Yokosuka, Japan. In Neurosci Lett, 2012
These results suggest that immobilization and immobilization with chewing differentially affect these two types of glucocorticoid receptors in the rat hippocampus.
Multiple folding states and disorder of ribosomal protein SA, a membrane receptor for laminin, anticarcinogens, and pathogens.
GeneRIF
Bedouelle et al., Paris, France. In Biochemistry, 2012
a high plasticity of RPSA, which could be important for its multiple cellular localizations and functional interactions
Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity.
GeneRIF
Hariri et al., Durham, United States. In Am J Psychiatry, 2012
Iso/Val (rs5522) genotype and childhood emotional neglect associated with greater amygdala reactivity
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