GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Nuclear receptor subfamily 3, group C, member 2
mineralocorticoid receptor, MLR, MCR, aldosterone receptor
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from
NCBI)
Top mentioned proteins:
Angiotensin II, CAN, HAD, V1a, Renin
Papers on
mineralocorticoid receptor
Corticosteroids and the retina: a role for the mineralocorticoid receptor.
Review
New
Paris, France. In Curr Opin Neurol, Feb 2016
RECENT FINDINGS: Recently, the over activation of the mineralocorticoid receptor (MR) pathway has been shown to cause fluid accumulation in the retina, choroidal vasodilation, and to promote retinal neovascularization in hypoxic conditions.
Mineralocorticoid Receptor Antagonists in End-Stage Renal Disease: Efficacy and Safety.
Review
New
New York City, United States. In Blood Purif, Feb 2016
UNASSIGNED: Mineralocorticoid receptor antagonists (MRAs) that block aldosterone's effects on both epithelial and non-epithelial receptors have become a mainstay of therapy for chronic heart failure.
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.
New
Lausanne, Switzerland. In Pflugers Arch, Feb 2016
Germline loss-of-function mutations of the mineralocorticoid receptor (MR) in humans and in mice lead to the "renal" form of type 1 pseudohypoaldosteronism (PHA-1), a case of aldosterone resistance characterized by salt wasting, dehydration, failure to thrive, hyperkalemia, and metabolic acidosis.
Aldosterone alters the chromatin structure of the murine endothelin-1 gene.
New
Gainesville, United States. In Life Sci, Feb 2016
SIGNIFICANCE: The evidence supports a model in which aldosterone activation of the mineralocorticoid receptor (MR) results in the MR-hormone complex binding at HRE at -671bp to open chromatin structure around other regulatory elements in the Edn1 gene.
Therapy modifications during hospitalization in patients with chronic heart failure.
New
Ljubljana, Slovenia. In Eur J Intern Med, Feb 2016
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists were prescribed to 78%, 58% and 20% of patients on admission and 72%, 65% and 23% at discharge, respectively.
Up-Regulation of FGF23 Release by Aldosterone.
New
Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
Aldosterone further increased Fgf23 transcript levels in UMR106 cells, an effect reversed by mineralocorticoid receptor blockers spironolactone and eplerenone, SGK1 inhibitor EMD638683, NFκB-inhibitor withaferin A, and Ca(2+) channel blocker YM58483.
Emerging Roles of the Mineralocorticoid Receptor in Pathology: Toward New Paradigms in Clinical Pharmacology.
Review
New
Impact
Paris, France. In Pharmacol Rev, Jan 2016
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators of hormone-regulated renal sodium reabsorption.
The Glucocorticoid Receptor: Cause or Cure for Obesity?
Review
New
Toledo, Philippines. In Am J Physiol Endocrinol Metab, Jan 2016
Alternative mechanisms are then proposed for the lipogenic actions of GCs, including induction of GC resistance by the GRβ isoform, and promotion of lipogenesis by GC activation of the mineralocorticoid receptor (MR).
Reversing methanogenesis to capture methane for liquid biofuel precursors.
New
United States. In Microb Cell Fact, Dec 2015
To capture methane, we cloned the enzyme methyl-coenzyme M reductase (Mcr) from an unculturable organism, anaerobic methanotrophic archaeal population 1 (ANME-1) from a Black Sea mat, into M. acetivorans to effectively run methanogenesis in reverse.
Mineralocorticoid Receptor Antagonists and Clinical Outcomes in Primary Aldosteronism: As Good as Surgery?
Review
New
Udine, Italy. In Horm Metab Res, Dec 2015
Treatment with mineralocorticoid receptor antagonists (MRAs) is currently recommended for PA patients with bilateral adrenal disease, but these agents effectively decrease blood pressure also in patients with unilateral disease, although concern remains for possible sex-related side effects.
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages.
New
Shanghai, China. In Plos One, Dec 2015
Eplerenone, a mineralocorticoid receptor (MR) antagonist, almost completely blocked Aldo-induced C18 ceramide production and HUVEC damages.
Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.
New
Impact
Hong Kong, Hong Kong. In Jama, Oct 2015
IMPORTANCE: Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events.
Mineralocorticoids in the heart and vasculature: new insights for old hormones.
Review
Impact
Freiburg, Germany. In Annu Rev Pharmacol Toxicol, 2014
Experimental studies using cell type-specific gene targeting of the mineralocorticoid receptor (MR) gene in mice have revealed the importance of extrarenal aldosterone signaling in cardiac myocytes, endothelial cells, vascular smooth cells, and macrophages.
Resistant hypertension: a review of diagnosis and management.
Review
Impact
Dallas, United States. In Jama, 2014
An increasing body of evidence has suggested benefits of mineralocorticoid receptor antagonists, such as eplerenone and spironolactone, in improving blood pressure control in patients with resistant hypertension, regardless of circulating aldosterone levels.
Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia.
Impact
New Haven, United States. In Cell Metab, 2013
The mineralocorticoid receptor (MR) is normally activated by aldosterone, which is produced in both volume depletion and hyperkalemia, states that require different homeostatic responses.
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.
Impact
GeneRIF
Boston, United States. In Nat Med, 2012
M<ice with smooth muscle cell-specific deficiency of the mineralocorticoid receptor have decreased blood pressure as they age without defects in renal sodium handling or vascular structure.
Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis.
GeneRIF
Australia. In Endocrinology, 2012
macrophage MR are necessary for the translation of inflammation and oxidative stress into interstitial and perivascular fibrosis after NO deficiency, even when plasma aldosterone is not elevated
Combination of chewing and stress up-regulates hippocampal glucocorticoid receptor in contrast to the increase of mineralocorticoid receptor under stress only.
GeneRIF
Yokosuka, Japan. In Neurosci Lett, 2012
These results suggest that immobilization and immobilization with chewing differentially affect these two types of glucocorticoid receptors in the rat hippocampus.
Multiple folding states and disorder of ribosomal protein SA, a membrane receptor for laminin, anticarcinogens, and pathogens.
GeneRIF
Paris, France. In Biochemistry, 2012
a high plasticity of RPSA, which could be important for its multiple cellular localizations and functional interactions
Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity.
GeneRIF
Durham, United States. In Am J Psychiatry, 2012
Iso/Val (rs5522) genotype and childhood emotional neglect associated with greater amygdala reactivity
