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Spondin 2, extracellular matrix protein

Mindin, SPON2, spondin-2
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Top mentioned proteins: HAD, CAN, F-spondin, thrombospondin-1, fibrillin-1
Papers on Mindin
Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.
Li et al., In Clin Sci (lond), 09 Apr 2015
UNASSIGNED: Mindin/spondin 2, an extracellular matrix (ECM) component that belongs to the thrombospondin type 1 (TSR) class of molecules, plays prominent roles in the regulation of inflammatory responses, angiogenesis and metabolic disorders.
TALEN-mediated mutagenesis in zebrafish reveals a role for r-spondin 2 in fin ray and vertebral development.
Yokoi et al., Sendai, Japan. In Febs Lett, Jan 2015
R-spondin (Rspo) encodes a multi-domain protein that modulates the Wnt-signaling pathway.
Distinct human stem cell populations in small and large intestine.
Lagasse et al., Pittsburgh, United States. In Plos One, Dec 2014
Here, we examine intrinsic differences between primary epithelial cells isolated from human fetal small and large intestine, after in vitro expansion, using the Wnt agonist R-spondin 2. We utilized flow cytometry, fluorescence-activated cell sorting, gene expression analysis and a three-dimensional in vitro differentiation assay to characterize their stem cell properties.
Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH]₂ vitamin D₃ potency to stimulate osteocalcin.
Reboul et al., Vandœuvre-lès-Nancy, France. In Biomed Mater Eng, Dec 2014
Osteocalcin (OCN), TGF-β1, Dickkopf-related protein 2 (DKK2), R-spondin 2 (Rspo2), Wnt5b, and low density lipoprotein related-receptor 1 (LRP1) were evaluated by real time RT-PCR.
N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype.
Neal et al., Cambridge, United Kingdom. In Oncogene, Dec 2014
Expression arrays of the knockdown and overexpression cell lines have identified nine genes that co-expressed with NAALADL2, which included membrane proteins and genes known to be androgen regulated, including the prostate cancer biomarkers AGR2 and SPON2.
R-spondin2 activates hepatic stellate cells and promotes liver fibrosis.
Yu et al., Jiaxing, China. In Dig Dis Sci, Oct 2014
As a potent Wnt pathway agonist, the role of roof plate-specific spondin-2 (R-Spondin2) in the hepatic fibrosis has not been well elucidated.
Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice.
Li et al., Wuhan, China. In J Hepatol, May 2014
Our previous studies indicated that Spondin 2 has a protective role in the context of cardiovascular and cerebrovascular diseases.
Capture and 3D culture of colonic crypts and colonoids in a microarray platform.
Allbritton et al., Chapel Hill, United States. In Lab Chip, 2014
After supplying the essential growth factors, epidermal growth factor, Wnt-3A, R-spondin 2 and noggin, 63 ± 13% of the crypts and 77 ± 8% of the colonoids cultured in the microstrainers over a 48-72 h period formed viable 3D colonoids.
Proteomic analysis of human osteoarthritis synovial fluid.
Pandey et al., Pune, India. In Clin Proteomics, 2013
These novel proteins included ADAM-like decysin 1 (ADAMDEC1), alanyl (membrane) aminopeptidase (ANPEP), CD84, fibulin 1 (FBLN1), matrix remodelling associated 5 (MXRA5), secreted phosphoprotein 2 (SPP2) and spondin 2 (SPON2).
RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.
Lu et al., Wenzhou, China. In Nat Commun, 2013
One of the family members, R-spondin 2 (RSPO2), has an important role in embryonic development, bone formation and myogenic differentiation; however, its role in human cancers remains largely unknown.
Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.
Li et al., Wuhan, China. In J Mol Med (berl), 2012
Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.
Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker.
Zhou et al., Beijing, China. In Plos One, 2011
Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa patients with metastasis.
Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
Li et al., Wuhan, China. In Cardiovasc Res, 2011
mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3beta and TGF-beta1-Smad signalling.
The role of the extracellular matrix protein mindin in airway response to environmental airways injury.
Hollingsworth et al., Durham, United States. In Environ Health Perspect, 2011
The data demonstrate that the extracellular matrix protein mindin modifies the airway response to both LPS and ozone.
Mindin: a novel marker for podocyte injury in diabetic nephropathy.
Tomino et al., Tokyo, Japan. In Nephrol Dial Transplant, 2011
High Mindin is associated with diabetic nephropathy in type 2 diabetes.
Role of mindin in diabetic nephropathy.
Tomino et al., Tokyo, Japan. In Exp Diabetes Res, 2010
Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins.
Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling.
Posey et al., Philadelphia, United States. In Curr Osteoporos Rep, 2010
R-spondins promote osteoblast differentiation and R-spondin-2 deficiency results in skeletal developmental defects.
Coat variation in the domestic dog is governed by variants in three genes.
Ostrander et al., Bethesda, United States. In Science, 2009
Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States.
The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities.
Klar et al., Jerusalem, Israel. In Int J Biochem Cell Biol, 2004
F-spondin and Mindin are members of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains.
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
Bevan et al., Durham, United States. In Nat Immunol, 2004
Mindin is a pattern-recognition molecule for microbial pathogens.
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