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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Spondin 2, extracellular matrix protein

Mindin, SPON2, spondin-2
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Top mentioned proteins: HAD, CAN, F-spondin, thrombospondin-1, ACID
Papers on Mindin
Multiple biomarkers biosensor with just-in-time functionalization: Application to prostate cancer detection.
New
Homs-Corbera et al., Barcelona, Spain. In Biosens Bioelectron, Apr 2016
As a proof-of-concept, the system has been tested and adjusted to quantify two proteins found in blood that are susceptible to be used combined, as a screening tool, to diagnose prostate cancer (PCa): prostate-specific antigen (PSA) and spondin-2 (SPON2).
SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.
New
Stein et al., Berlin, Germany. In Oncogene, Jan 2016
We identified more than 1300 genes at least twofold differentially expressed, including the gene SPON2 (Spondin 2) as 90-fold upregulated transcriptional target of MACC1.
Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.
New
Buchsbaum et al., Birmingham, United States. In Lab Invest, Jan 2016
Expression of R-spondin 2 (RSPO2), RSPO3, PORCN, WLS, AXIN2, and three previously characterized RSPO fusion transcripts were assessed using Taqman assays.
Mindin deficiency protects the liver against ischemia/reperfusion injury.
New
Li et al., Shanghai, China. In J Hepatol, Nov 2015
Our previous studies revealed that Mindin is involved in the pathogenesis of ischemic stroke.
Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics.
New
Liu et al., Shanghai, China. In Oncotarget, Nov 2015
Western blots confirmed the fibroblast-specific secretion of filamin C, COL6A3, COL4A1 and spondin-2.
Identification of tool use acquisition-associated genes in the primate neocortex.
New
Iriki et al., Wako, Japan. In Dev Growth Differ, Aug 2015
Using quantitative reverse transcription-polymerase chain reaction and histochemical analysis, we confirmed at least three genes (ADAM19, SPON2, and WIF1) with statistically different expression levels in neurons and glial cells.
Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
New
Jones et al., Oxford, United Kingdom. In J Struct Biol, Aug 2015
The four secreted R-spondin (Rspo1-4) proteins of vertebrates function as stem cell growth factors and potentiate canonical Wnt signalling.
Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients.
New
Liu et al., Shanghai, China. In Oncotarget, Jul 2015
Spondin-2 is a conserved secreted extracellular matrix protein and a candidate cancer biomarker.
Evaluation of Serum Spondin 2 Levels in the Different Stages of Type 2 Diabetic Nephropathy.
New
Esen et al., Bursa, Turkey. In Nephrology (carlton), Jun 2015
AIM: In this pilot study, we aimed to determine whether serum SPON2 is a useful biomarker in the detection of nephropathy in patients with Type 2 Diabetes (T2D) and to compare serum SPON2 levels with 24-hour urinary albumin excretion rate (UAER) in patients with Diabetic Nephropathy (DN) at different stages.
A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers.
Gambhir et al., Stanford, United States. In Plos One, 2014
To address this unmet clinical need, we report a piezeoelectric/magnetic bead-based assay to quantitate prostate specific antigen (PSA; free and total), prostatic acid phosphatase, carbonic anhydrase 1 (CA1), osteonectin, IL-6 soluble receptor (IL-6sr), and spondin-2.
Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.
GeneRIF
Li et al., Wuhan, China. In J Mol Med (berl), 2012
Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.
Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker.
GeneRIF
Zhou et al., Beijing, China. In Plos One, 2011
Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa patients with metastasis.
Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
GeneRIF
Li et al., Wuhan, China. In Cardiovasc Res, 2011
mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3beta and TGF-beta1-Smad signalling.
The role of the extracellular matrix protein mindin in airway response to environmental airways injury.
GeneRIF
Hollingsworth et al., Durham, United States. In Environ Health Perspect, 2011
The data demonstrate that the extracellular matrix protein mindin modifies the airway response to both LPS and ozone.
Mindin: a novel marker for podocyte injury in diabetic nephropathy.
GeneRIF
Tomino et al., Tokyo, Japan. In Nephrol Dial Transplant, 2011
High Mindin is associated with diabetic nephropathy in type 2 diabetes.
Role of mindin in diabetic nephropathy.
Review
Tomino et al., Tokyo, Japan. In Exp Diabetes Res, 2010
Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins.
Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling.
Review
Posey et al., Philadelphia, United States. In Curr Osteoporos Rep, 2010
R-spondins promote osteoblast differentiation and R-spondin-2 deficiency results in skeletal developmental defects.
Coat variation in the domestic dog is governed by variants in three genes.
Impact
Ostrander et al., Bethesda, United States. In Science, 2009
Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States.
The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities.
Review
Klar et al., Jerusalem, Israel. In Int J Biochem Cell Biol, 2004
F-spondin and Mindin are members of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains.
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
Impact
GeneRIF
Bevan et al., Durham, United States. In Nat Immunol, 2004
Mindin is a pattern-recognition molecule for microbial pathogens.
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