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Spondin 2, extracellular matrix protein

Mindin, SPON2, spondin-2
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Top mentioned proteins: HAD, CAN, F-spondin, fibrillin-1, thrombospondin-1
Papers on Mindin
R-spondin2 activates hepatic stellate cells and promotes liver fibrosis.
Yu et al., Jiaxing, China. In Dig Dis Sci, 31 Oct 2014
As a potent Wnt pathway agonist, the role of roof plate-specific spondin-2 (R-Spondin2) in the hepatic fibrosis has not been well elucidated.
Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice.
Li et al., Wuhan, China. In J Hepatol, May 2014
Our previous studies indicated that Spondin 2 has a protective role in the context of cardiovascular and cerebrovascular diseases.
Capture and 3D culture of colonic crypts and colonoids in a microarray platform.
Allbritton et al., Chapel Hill, United States. In Lab Chip, Jan 2014
After supplying the essential growth factors, epidermal growth factor, Wnt-3A, R-spondin 2 and noggin, 63 ± 13% of the crypts and 77 ± 8% of the colonoids cultured in the microstrainers over a 48-72 h period formed viable 3D colonoids.
Spondin-2, a secreted extracellular matrix protein, is a novel diagnostic biomarker for prostate cancer.
Ditonno et al., Bari, Italy. In J Urol, Dec 2013
PURPOSE: SPON2 belongs to the F-spondin family of secreted extracellular matrix proteins.
RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.
Lu et al., Wenzhou, China. In Nat Commun, Dec 2013
One of the family members, R-spondin 2 (RSPO2), has an important role in embryonic development, bone formation and myogenic differentiation; however, its role in human cancers remains largely unknown.
Proteomic analysis of human osteoarthritis synovial fluid.
Pandey et al., Pune, India. In Clin Proteomics, Dec 2013
These novel proteins included ADAM-like decysin 1 (ADAMDEC1), alanyl (membrane) aminopeptidase (ANPEP), CD84, fibulin 1 (FBLN1), matrix remodelling associated 5 (MXRA5), secreted phosphoprotein 2 (SPP2) and spondin 2 (SPON2).
N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype.
Neal et al., Cambridge, United Kingdom. In Oncogene, Dec 2013
Expression arrays of the knockdown and overexpression cell lines have identified nine genes that co-expressed with NAALADL2, which included membrane proteins and genes known to be androgen regulated, including the prostate cancer biomarkers AGR2 and SPON2.
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.
Largaespada et al., Minneapolis, United States. In Cancer Discov, Jun 2013
In human neurofibromas and MPNSTs, activation of Wnt signaling increased with tumor grade and was associated with downregulation of β-catenin destruction complex members or overexpression of a ligand that potentiates Wnt signaling, R-spondin 2 (RSPO2).
Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2.
Smidt et al., Amsterdam, Netherlands. In Plos One, 2012
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification.
R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea.
Gruenheid et al., Montréal, Canada. In Nat Commun, 2012
Citrobacter rodentium is a natural mouse pathogen widely used as a model for enteropathogenic and enterohemorrhagic Escherichia coli infections in humans.
Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.
Li et al., Wuhan, China. In J Mol Med (berl), 2012
Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.
Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker.
Zhou et al., Beijing, China. In Plos One, 2011
Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa patients with metastasis.
Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
Li et al., Wuhan, China. In Cardiovasc Res, 2011
mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3beta and TGF-beta1-Smad signalling.
The role of the extracellular matrix protein mindin in airway response to environmental airways injury.
Hollingsworth et al., Durham, United States. In Environ Health Perspect, 2011
The data demonstrate that the extracellular matrix protein mindin modifies the airway response to both LPS and ozone.
Mindin: a novel marker for podocyte injury in diabetic nephropathy.
Tomino et al., Tokyo, Japan. In Nephrol Dial Transplant, 2011
High Mindin is associated with diabetic nephropathy in type 2 diabetes.
Role of mindin in diabetic nephropathy.
Tomino et al., Tokyo, Japan. In Exp Diabetes Res, 2010
Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins.
Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling.
Posey et al., Philadelphia, United States. In Curr Osteoporos Rep, 2010
R-spondins promote osteoblast differentiation and R-spondin-2 deficiency results in skeletal developmental defects.
Coat variation in the domestic dog is governed by variants in three genes.
Ostrander et al., Bethesda, United States. In Science, 2009
Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States.
The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities.
Klar et al., Jerusalem, Israel. In Int J Biochem Cell Biol, 2004
F-spondin and Mindin are members of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains.
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
Bevan et al., Durham, United States. In Nat Immunol, 2004
Mindin is a pattern-recognition molecule for microbial pathogens.
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