Current understanding of mdig/MINA in human cancers.
Detroit, United States. In Genes Cancer, Jul 2015
UNLABELLED: Mineral dust-induced gene, mdig has recently been identified and is known to be overexpressed in a majority of human cancers and holds predictive power in the poor prognosis of the disease.
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Oxford, United Kingdom. In Nature, 2014
In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively.
Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics.
Hradec Králové, Czech Republic. In Int J Mol Sci, 2012
Current efforts at treatments for OPNA exposure are focused on non-quaternary reactivators, monoisonitrosoacetone oximes (MINA), and diacylmonoxime reactivators (DAM).
Transcriptional activation of Mina by Sp1/3 factors.
Memphis, United States. In Plos One, 2012
Mina is an epigenetic gene regulatory protein known to function in multiple physiological and pathological contexts, including pulmonary inflammation, cell proliferation, cancer and immunity.
Mina, an Il4 repressor, controls T helper type 2 bias.
Yokohama, Japan. In Nat Immunol, 2009
Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression.