The kindlin family: functions, signaling properties and implications for human disease.
Martinsried, Germany. In J Cell Sci, Feb 2016
Mutations in the KINDLIN-1 (also known as FERMT1) gene cause Kindler syndrome (KS) - in which mainly skin and intestine are affected, whereas mutations in the KINDLIN-3 (also known as FERMT3) gene cause leukocyte adhesion deficiency type III (LAD III), which is characterized by impaired extravasation of blood effector cells and severe, spontaneous bleedings.
Regulation of integrins in platelets.
Philadelphia, United States. In Biopolymers, Jul 2015
Second, the agonist-stimulated binding of the cytosolic proteins talin and kindlin-3 to the β3 cytosolic tail rapidly causes αIIbβ3 activation by disrupting the intramolecular interactions constraining αIIbβ3 activity.
Kindlin-3 in the immune system.
Helsinki, Finland. In Am J Clin Exp Immunol, 2013
In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system.