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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ERBB receptor feedback inhibitor 1

Mig-6, gene 33, RALT, ERRFI1
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: EGFR, Epidermal Growth Factor, CAN, V1a, ERK
Papers on Mig-6
Alt a 15 is a new cross-reactive minor allergen of Alternaria alternata.
New
Martínez et al., Vitoria-Gasteiz, Spain. In Immunobiology, Feb 2016
Immunoblotting analyses revealed that IgE antibodies from A. alternata-sensitized patients (n=59) bound to rAlt a 15 with a prevalence of 10.2%.
Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells.
New
Xu et al., Valhalla, United States. In Oncotarget, Feb 2016
In this study, we investigated the potential role of Gene 33 (ERRFI1, Mig6), a multifunctional adaptor protein, in Cr(VI)-mediated lung carcinogenesis.
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
New
Zheng et al., Frederick, United States. In Nucleic Acids Res, Jan 2016
By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we found that SRSF3 regulates the expression of 60 genes including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLINT1, PKP4, KIF23, CHK1, SMC2, CKLF, MAP4, MBNL1, MELK, DDX5, PABPC1, MAP4K4, Sp1 and SRSF1, which are primarily associated with cell proliferation or cell cycle.
Overexpression and knockout of miR-126 both promote leukemogenesis.
New
Chen et al., Chicago, United States. In Blood, Nov 2015
Mechanistically, miR-126 overexpression activates genes that are highly expressed in LSCs/LICs and/or primitive hematopoietic stem/progenitor cells, likely through targeting ERRFI1 and SPRED1, whereas miR-126 knockout activates genes that are highly expressed in committed, more differentiated hematopoietic progenitor cells, presumably through inducing FZD7 expression.
Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics.
Review
New
Segatto et al., Roma, Italy. In Semin Cell Dev Biol, Nov 2015
This review focuses on MIG6, an IFI that restrains ErbB signaling by mediating ErbB kinase suppression and receptor down-regulation.
Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells.
New
Zhang et al., Zhengzhou, China. In Pharm Biol, Nov 2015
RESULTS AND CONCLUSION: DMU-212 was found to regulate a diverse range of genes, including cytokines (IL8, selectin E, MPZL2, EGR1, CCL20, ITGB8, CXCL1, VCAM1, KITLG, and AREG), transport proteins (TRPC4, SLC41A2, SLC17A5, and CREB5), metabolism (CYP1B1, CYP1A1, PDK4, CSNK1G1, MVK, TCEB3C, and CDKN3), enzymes (RAB23, SPHK1, CHSY3, PLAU, PLA2G4C, and MMP10), and genes involved in signal transduction (TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and GEM), cell migration and angiogenesis (ERRFI1, HBEGF, and NEDD9), and apoptosis (TNFSF15, TNFRSF9, CD274, BCL2L11, BIRC3, TNFAIP3, and TIFA), as well as other genes with unknown function (PGM5P2, SNORD1142, LOC151760, KRTAP5-2, C1orf110, SNORA14A, MIR31, C2CD4B, SCARNA4, C2orf66, SC4MOL, LOC644714, and LOC283392).
DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling.
New
Yoon et al., Seoul, South Korea. In Biochim Biophys Acta, Oct 2015
Mitogen-inducible gene 6 (MIG6) is a tumor suppressor implicated in the development of human cancers; however, the regulatory mechanisms of MIG6 remain unknown.
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
New
Eck et al., Boston, United States. In Nat Struct Mol Biol, Sep 2015
Loss of Mig6 is a driving event in human cancer; analysis of 1,057 gliomas reveals frequent focal deletions of ERRFI1, the gene that encodes Mig6, in EGFR-amplified glioblastomas.
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.
Zebisch et al., Dublin, Ireland. In Plos One, 2014
Mitogen-inducible gene-6 (MIG-6) is a potent inhibitor of the EGFR and has been demonstrated to function as a tumor suppressor.
NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma.
Li et al., Guangzhou, China. In Mol Cancer, 2014
The association between an RNA-induced silencing complex and QKI, mitogen-inducible gene 6 (MIG6), S-phase kinase-associated protein 1 (SKP1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA was tested with microribonucleoprotein immunoprecipitation and real-time PCR.
Mould allergens: Where do we stand with molecular allergy diagnostics?: Part 13 of the series Molecular Allergology.
Review
Raulf et al., Bochum, Germany. In Allergo J Int, 2013
These include rAlt a 1, the major allergen in Alternaria alternata-sensitized individuals, and enolase rAlt a 6 with it potential cross-reactivity to mould, food and natural latex allergens.
Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling.
GeneRIF
Wang et al., Shenyang, China. In Mol Carcinog, 2012
results indicate that downregulated Mig-6 in NSCLC tissues may serve as a new marker that can predict the activation of EGFR signaling pathway
Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling.
GeneRIF
Kitagawa et al., Hamamatsu, Japan. In Embo J, 2012
These results suggest that Chk1 phosphorylates Mig-6 on Ser 251, resulting in the inhibition of Mig-6, and that Chk1 acts as a positive regulator of EGF signalling.
Down-regulation of mitogen-inducible gene 6, a negative regulator of EGFR, enhances resistance to MEK inhibition in KRAS mutant cancer cells.
GeneRIF
Kim et al., Seoul, South Korea. In Cancer Lett, 2012
Treatment with AZD6244 reduced the expression of mitogen-inducible gene 6 (MIG6).
PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells.
GeneRIF
Jongstra et al., Toronto, Canada. In Oncotarget, 2011
Knockdown of PIM-1 but not of PIM-2 or PIM-3 also up regulates MIG6 expression, which identifies MIG6 as a PIM-1 regulated gene prostate cancer cells.
Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.
GeneRIF
Vande Woude et al., Grand Rapids, United States. In Plos One, 2011
MIG-6 gene is differentially regulated in lung cancer and melanoma and can be epigenetically silenced by inhibitors of methylation and histone deacetylation.
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors.
Review
Alemà et al., Roma, Italy. In J Cell Sci, 2011
In mammalian cells, four EGFR inducible feedback inhibitors (IFIs), namely LRIG1, RALT (also known as MIG6 and ERRFI1), SOCS4 and SOCS5, have been discovered recently.
Feedback inhibitors of the epidermal growth factor receptor signaling pathways.
Review
Gotoh, Tokyo, Japan. In Int J Biochem Cell Biol, 2009
The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Impact
GeneRIF
Kuriyan et al., Berkeley, United States. In Nature, 2007
Crystal structures of complexes between the EGFR kinase domain and a fragment of MIG6 show that a approximately 25-residue epitope (segment 1) from MIG6 binds to the distal surface of the C lobe of the kinase domain
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation.
Impact
GeneRIF
Klein et al., Martinsried, Germany. In Nat Med, 2006
Results indicate that Mig6 is a specific negative regulator of Egfr signaling in skin morphogenesis and is a novel tumor suppressor of Egfr-dependent carcinogenesis.
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