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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.


Midkine, MDK
Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis (summary by Reynolds et al., 2004 [PubMed 15197188]).[supplied by OMIM, Nov 2010] (from NCBI)
Papers on Midkine
Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis.
Walzog et al., M√ľnchen, Germany. In Am J Physiol Heart Circ Physiol, 2012
Identify endothelial cells as the source of soluble midkine in the vascular system during hypoxia and defined midkine as a pivotal player of angiogenesis during ischemia in nonmalignant tissue.
Novel functional proteins interact with midkine in hepatic cancer cells.
Zheng et al., Hangzhou, China. In Hepatobiliary Pancreat Dis Int, 2012
Identify midkine interacting proteins in liver tumor cells.
Plasma levels of midkine (neurite growth-promoting factor 2) are not associated with plasma fibrinolytic potential or risk of venous thrombosis.
Rosendaal et al., In J Thromb Haemost, 2012
Letter: Plasma levels of midkine are not associated with plasma fibrinolytic potential or risk of venous thrombosis.
Expression of midkine and vascular endothelial growth factor in gastric cancer and the association of high levels with poor prognosis and survival.
Lu et al., Putian, China. In Mol Med Report, 2012
Expression of MK and VEGF is increased in gastric cancer and increased expression is closely correlated with poor prognosis and survival
Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition.
Rohrer et al., Frankfurt am Main, Germany. In Development, 2011
Results demonstrate that the extent and timing of sympathetic neurogenesis is controlled by Midkine and Alk signaling.
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