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MID2 Mid2p

MID2, Mid2p, midline 2
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: Midline, CAN, Ubiquitin, Actin, HAD
Papers on MID2
The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.
Torres et al., Los Angeles, United States. In Cell Rep, Feb 2016
Mid1 and Mid2 are ubiquitin ligases that regulate microtubule dynamics and whose mutation is associated with X-linked developmental disorders.
Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.
Zou et al., Guangzhou, China. In Mol Genet Genomic Med, Jan 2016
MID2, a homolog of MID1, shares high structural and functional similarities with MID1.
A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation.
Huang et al., Shanghai, China. In Gene, Sep 2015
Ten genes (i.e., ZNF711, SRPX2, RAB40AL, MID2, ACSL4, PAK3, UBE2A, UPF3B, CUL4B, and GRIA3) in the duplication interval have been associated with mental retardation.
MID2 can substitute for MID1 and control exocytosis of lytic granules in cytotoxic T cells.
Geisler et al., Copenhagen, Denmark. In Apmis, Aug 2015
We wondered why the MID1 gene knock-out did not affect exocytosis and cytotoxicity more severely and speculated whether MID2, a close homologue of MID1, might partially compensate for the loss of MID1 in MID1(-/-) CTL.
Surface and boney landmarks for sacral neuromodulation: a cadaveric study.
Francis et al., Louisville, United States. In Int Urogynecol J, Feb 2015
RESULTS: Mean distance from the tip of coccyx to S3 was 9.26 cm (±0.84), from S3 to midline 2.30 cm (±0.2); from needle to S3 1.25 cm, and needle placement was as likely to be placed above or below S3; and S2-S3 and S3-S4 interforamenal distance 1.48 cm (±0.30) and 1.48 cm (±0.24), respectively.
Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex.
Lu et al., Shanghai, China. In J Cell Sci, 2014
In fission yeast (Schizosaccharomyces pombe), Spn1-Spn4 are assembled into a primary septin ring at the division site, and the subsequent recruitment of Mid2 to the structure results in a stable septin ring.
Targeted deep resequencing identifies MID2 mutation for X-linked intellectual disability with varied disease severity in a large kindred from India.
Thelma et al., New Delhi, India. In Hum Mutat, 2014
We report a novel missense mutation (c.1040G>A, p.Arg347Gln) in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred.
Minimally invasive intradural spinal dural arteriovenous fistula ligation.
Elbert et al., Phoenix, United States. In World Neurosurg, 2013
The procedure entailed localization with the use of fluoroscopy followed by a midline 2.2-cm skin opening.
Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle.
Yu et al., Ithaca, United States. In Am J Hum Genet, 2013
For example, TRIM27, a known cancer-associated protein, interacts with three proteins (MID2, TRIM42, and SIRPA) through two different interfaces.
The high-osmolarity glycerol- and cell wall integrity-MAP kinase pathways of Saccharomyces cerevisiae are involved in adaptation to the action of killer toxin HM-1.
Komiyama et al., Niigata, Japan. In Yeast, 2012
mid2, rom2 and bck1 cells showed HM-1-sensitive phenotypes and decreased inductions of phospho-Slt2p in response to HM-1.
Initial application of reduced port surgery using the single port access technique for laparoscopic canine ovariectomy.
Agnello et al., Philadelphia, United States. In Vet Surg, 2012
In an 18-kg mix breed dog (dog 3), a "single port rescue" was required and located on midline 2-cm caudal to the umbilicus.
TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance.
Huang et al., Beijing, China. In J Genet Genomics, 2011
Members of the TRIM-9/C-I subfamily of TRIM proteins, including TRIM-9, MID1 and MID2, have neuronal functions and are associated with neurological diseases.
Characterization of sensor-specific stress response by transcriptional profiling of wsc1 and mid2 deletion strains and chimeric sensors in Saccharomyces cerevisiae.
Arroyo et al., Madrid, Spain. In Omics, 2010
Cell wall damage is detected mainly by Wsc1 and Mid2, which are the dominant sensors of CWI pathway.
Midline Submental Orotracheal Intubation in Maxillofacial Injuries: A Substitute to Tracheostomy Where Postoperative Mechanical Ventilation is not Required.
Kang et al., Bareilly, India. In J Anaesthesiol Clin Pharmacol, 2010
cm skin incision was made in the submental region in the midline 2.0 cm behind the symphysis and endotracheal tube was taken out through this incision in all the cases.
Mid1p/anillin and the septation initiation network orchestrate contractile ring assembly for cytokinesis.
Simanis et al., Lausanne, Switzerland. In Genes Dev, 2008
Data show that Mid1p/anillin and the septation initiation network orchestrate contractile ring assembly for cytokinesis.
Protein N-glycosylation determines functionality of the Saccharomyces cerevisiae cell wall integrity sensor Mid2p.
Strahl et al., Heidelberg, Germany. In Mol Microbiol, 2008
The extent of the N-linked glycan and its distance from the plasma membrane affect Mid2p function, suggesting the N-glycan to be directly involved in Mid2p sensing.
Season-to-Season Variations of Physiological Fitness Within a Squad of Professional Male Soccer Players.
Butterly et al., London, United Kingdom. In J Sports Sci Med, 2007
The CMJ tests showed a test-to-test improvement of 6.3% (best of 3 jumps) (p = 0.03, p < 0.05) and 10.3% (20-s sustained jumping test) (p = 0.007, p < 0.01) between PPS2 and MID2 and thereafter remained stable.
Functional analyses of the extra- and intracellular domains of the yeast cell wall integrity sensors Mid2 and Wsc1.
Heinisch et al., Osnabrück, Germany. In Febs Lett, 2007
Chimers of MID2 fused to GFP have been employed to show that intracellular and membrane distribution is only dependent on a membrane-anchored cytoplasmic tail.
An Xq22.3 duplication detected by comparative genomic hybridization microarray (Array-CGH) defines a new locus (FGS5) for FG syndrome.
Passos-Bueno et al., São Paulo, Brazil. In Am J Med Genet A, 2006
MID2 is a candidate gene for FG syndrome.
Ace2p contributes to fission yeast septin ring assembly by regulating mid2+ expression.
Gould et al., Nashville, United States. In J Cell Sci, 2006
Mid2p production is controlled by Ace2p functioning downstream of Sep1p.
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