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TAO kinase 1

microtubule affinity regulating kinase, PSK2, TAO1, MARKK
protein kinase; involved in regulation of the p38-containing stress-responsive MAP kinase pathway [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, MARK, ACID, V1a, PAK1
Papers on microtubule affinity regulating kinase
Identification of Psk2, Skp1, and Tub4 as trans-acting factors for uORF-containing ROK1 mRNA in Saccharomyces cerevisiae.
New
Kim et al., Taejŏn, South Korea. In J Microbiol, Sep 2015
We identified Psk2 (PAS kinase), Skp1 (kinetochore protein) and Tub4 (γ-tubulin protein) as ROK1 5'UTR-interacting proteins using yeast three-hybrid system.
Phytosulfokine peptide signaling controls pollen tube growth and funicular pollen tube guidance in Arabidopsis thaliana.
New
Sauter et al., Kiel, Germany. In Physiol Plant, Apr 2015
Expression analysis revealed PSK precursor and PSK receptor gene activity in reproductive organs with strong expression of PSK2 in pollen.
A protein kinase screen of Neurospora crassa mutant strains reveals that the SNF1 protein kinase promotes glycogen synthase phosphorylation.
Bertolini et al., Almozara, Spain. In Biochem J, 2015
We identified multiple kinases that have already been described as controlling glycogen metabolism in different organisms, such as NcSNF1, NcPHO85, NcGSK3, NcPKA, PSK2 homologue and NcATG1.
MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.
Jan et al., San Francisco, United States. In Neuron, 2015
Furthermore, using stable isotope labeling by amino acids in culture (SILAC), we show that phosphorylated TAO1/2 associates with Myosin Va and is necessary for its dendritic localization, thus revealing a mechanism for excitatory synapse development in the mammalian CNS.
AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for Alzheimer disease.
Roberson et al., Birmingham, United States. In J Biomol Screen, 2014
We used these assays to map the binding site on Tau for Fyn to the fifth and sixth PXXP motifs to show that AD-associated phosphorylation at microtubule affinity regulating kinase sites increases the affinity of the Tau-Fyn interaction and to identify Tau-Fyn interaction inhibitors by high-throughput screening.
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.
Draviam et al., Cambridge, United Kingdom. In Open Biol, 2014
Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes.
PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast.
Xu et al., Quanzhou, China. In Fems Microbiol Lett, 2014
In yeast, PSK1 and PSK2 are two partially redundant PASK homologs.
Emerging modes of PINK1 signaling: another task for MARK2.
Review
Mandelkow et al., Hamburg, Germany. In Front Mol Neurosci, 2013
The first identified activating kinase of PINK1 is MAP/microtubule affinity regulating kinase 2 (MARK2), which phosphorylates T313, a frequent mutation site linked to PD. Kinases of the MARK2 family perform diverse functions in neuronal polarity, transport, migration, and neurodegeneration such as Alzheimer disease (AD).
Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
Review
Li et al., Hong Kong, Hong Kong. In Int J Mol Sci, 2013
LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc.
MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.
von Euler et al., Södertälje, Sweden. In Acta Neuropathol Commun, 2013
One of the earliest phosphorylated sites on tau is Ser262 that is preferentially phosphorylated by microtubule affinity regulating kinase (MARK), of which four isoforms exist.
Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.
Peters et al., In Toxicol Sci, 2013
Microtubule-associated protein/microtubule affinity regulating kinase (MARK) inhibitors decrease blood pressure in dogs, whereas checkpoint kinase (Chk) inhibitors (AZD7762, SCH900776) exhibit dose-limiting CV toxicities in clinical trials.
Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.
Morris et al., London, United Kingdom. In J Biol Chem, 2013
Here we show that tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases.
The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
GeneRIF
Harvey et al., Melbourne, Australia. In Dev Cell, 2011
Human TAO1 can phosphorylate and activate human MST2
PSK2 coordinates glucose metabolism and utilization to maintain ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast.
GeneRIF
Xu et al., Japan. In Arch Biochem Biophys, 2011
S. cerevisiae in culture showed oscillation in PSK2 mRNA levels with a definite phase relationship to the respiratory oscillation.
Re-evaluating the role of Tao1 in the spindle checkpoint.
GeneRIF
Taylor et al., Manchester, United Kingdom. In Chromosoma, 2010
Data do not support the notion that Tao1 is a component of the spindle checkpoint.
Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
GeneRIF
Nigg et al., München, Germany. In Chromosoma, 2010
the apparent role of the Tao1 kinase in spindle checkpoing signaling might in reality reflect an off-target effect produced by particular Tao1-directed siRNA oligonucleotides on Mad2
Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
GeneRIF
Mandelkow et al., Hamburg, Germany. In Mol Biol Cell, 2008
Spred1-MARKK binding has no effect on the activity of MARKK; therefore, it does not change microtubule (MT) stability.
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Impact
GeneRIF
Elledge et al., Cambridge, United States. In Nat Cell Biol, 2007
Functional analysis of the human Tao1 ortholog.
Tau therapeutic strategies for the treatment of Alzheimer's disease.
Review
Churcher, Stevenage, United Kingdom. In Curr Top Med Chem, 2005
In order to intervene pharmacologically in this disease process, much effort has been expended in order to identify and inhibit the kinases responsible for pathogenic hyperphosphorylation and many candidate kinases have been investigated including glycogen synthase kinase (GSK-3), cyclin-dependant kinase-5 (Cdk-5), MAPK family members (extracellular signal-regulated kinases 1 and 2 [Erk-1 and 2], MEK [MAP kinase kinase], c-Jun NH(2)-terminal kinases (JNKs) and p38), casein kinase, calcium calmodulin-dependant kinase II (CaMK-II), microtubule affinity regulating kinase (MARK), protein kinase A (PKA/cAMP-dependant protein kinase) and others.
Multiresistant Staphylococcus aureus: genetics and evolution of epidemic Australian strains.
Review
May et al., Australia. In J Antimicrob Chemother, 1988
Molecular and genetic analysis of multiresistant isolates of Staphylococcus aureus from widely separated hospitals in Australia has demonstrated that these are clearly related, and that the predominant strains possess up to three different plasmids, which fall into the following classes: (i) small 1.6 kb plasmids, such as pSK3, which are phenotypically cryptic, (ii) 4.5 kb chloramphenicol resistance plasmids, such as pSK2, and (iii) the pSK1 family of multiresistance plasmids, which range in size from 20 to 42 kb and variously encode resistance to antiseptics and disinfectants, trimethoprim (Tpr), penicillin (Pcr) and the aminoglycosides gentamicin, tobramycin and kanamycin (Gmr Tmr Kmr).
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