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Microsomal glutathione S-transferase 1

microsomal glutathione S-transferase, microsomal GST, MGST1, microsomal glutathione S-transferase 1
enzyme that catalyzes the transfer of glutathione onto hydrophobic substrates [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GST, ACID, CAN, HAD, fibrillin-1
Papers on microsomal glutathione S-transferase
Soyabean glycinin depresses intestinal growth and function in juvenile Jian carp (Cyprinus carpio var Jian): protective effects of glutamine.
New
Feng et al., Chengdu, China. In Br J Nutr, Dec 2015
However, dietary glycinin exposure decreased both the activity and mRNA levels of nine isoforms of glutathione-S-transferase (GST) (α, μ, π, ρ, θ, κ, mGST1, mGST2 and mGST3), indicating toxicity to this enzyme activity and corresponding isoform gene expressions.
Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle.
New
Hayes et al., Australia. In Mamm Genome, Dec 2015
There was statistical support for imputed sequence variants in or close to BTRC, MGST1, SLC37A1, STAT5A, STAT5B, PAEP, VDR, CSF2RB, MUC1, NCF4, and GHDC associated with milk production, and EPGN for calving interval.
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
New
Rinaldo-Matthis et al., Stockholm, Sweden. In Biochim Biophys Acta, Oct 2015
In contrast to LTC4S, MGST2 displays a 1/3 the sites reactivity, a mechanism shared with the more distant family member MGST1 and recently suggested also for microsomal prostaglandin E synthase-1.
Expression profile of eight glutathione S-transferase genes in Crassostrea ariakensis after exposure to DSP toxins producing dinoflagellate Prorocentrum lima.
New
Yang et al., Guangzhou, China. In Toxicon, Oct 2015
In this study, changes in eight GSTs mRNA level including GST-α, GST-σ, GST-ω, GST-π, GST-μ, GST-ρ, GST-θ and microsomal GST (mGST) in the oyster Crassostrea ariakensis after exposure to Prorocentrum lima have been evaluated by quantitative real-time PCR.
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.
New
Beech et al., Leeds, United Kingdom. In Arterioscler Thromb Vasc Biol, Sep 2015
The signaling pathway coupling VEGF to the effect on Orai3 involved activation of phospholipase Cγ1, Ca(2+) release, cytosolic group IV phospholipase A2α, arachidonic acid production, and, in part, microsomal glutathione S-transferase 2, an enzyme which catalyses the formation of leukotriene C4 from arachidonic acid.
Rhodnius prolixus supergene families of enzymes potentially associated with insecticide resistance.
New
Mesquita et al., Rio de Janeiro, Brazil. In Insect Biochem Mol Biol, Jul 2015
One microsomal GST gene was found and the cytosolic GST gene count (14 genes) is extremely low when compared to the other hemipteran species with sequenced genomes.
Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.
New
Impact
GECCO et al., Atlanta, United States. In Jama, Apr 2015
near the MGST1 gene showed a genome-wide significant interaction with aspirin and/or NSAID use (P = 4.6 × 10(-9) for interaction).
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
Phelan et al., Tampa, United States. In Plos One, 2014
In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects.
The trabecular meshwork in normal eyes and in exfoliation glaucoma.
Review
Kaufman et al., Madison, United States. In J Glaucoma, 2014
Genes differentially expressed in diseased ocular tissue or in cultured HTM cell models, and thus implicated in the disease process, include SOD2, ALDH1A1, MGST1, LOX, and LOXL1, elements of the transforming growth factor-β/bone morphogenetic protein/SMAD signaling pathways, connective tissue growth factor, matrix metalloproteinase-2, a tissue inhibitor of metalloproteinases also known as TIMP-2, and endothelin-1 (ET-1).
Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance.
GeneRIF
Morgenstern et al., Stockholm, Sweden. In Mol Pharm, 2011
Two doxorubicin derivatives/prodrugs (DNS-DOX; MNS-DOX) are substrates for MGST1; neoplasm drug resistance can be overcome in cell lines over-expressing recombinant MGST1.
Role of MGST1 in reactive intermediate-induced injury.
Review
Schaffert, Omaha, United States. In World J Gastroenterol, 2011
Microsomal glutathione transferase (MGST1, EC 2.5.1.18)
Microsomal glutathione transferase 1: mechanism and functional roles.
Review
Johansson et al., Stockholm, Sweden. In Drug Metab Rev, 2011
Microsomal glutathione transferase 1 (MGST1) belongs to a superfamily named MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism).
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Review
Hayes et al., Dundee, United Kingdom. In Drug Metab Rev, 2011
In this article we have reviewed the literature describing the mechanisms by which cytosolic and microsomal GST are up-regulated by xenobiotics, drugs, cytokines and endotoxin.
Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation.
Review
Imaizumi et al., Okinawa, Japan. In Drug Metab Rev, 2011
In mitochondria, soluble (kappa, alpha, mu, pi, zeta) and membrane-bound glutathione transferases (GSTs) (MGST1) are distributed.
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1.
GeneRIF
Wang et al., Louisville, United States. In Mech Ageing Dev, 2011
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1.
Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study.
GeneRIF
Morgenstern et al., Stockholm, Sweden. In Free Radic Biol Med, 2011
MGST1 protects cells (and mitochondria) by both conjugation and glutathione peroxidase functions. A new protective mechanism against cisplatin is also indicated
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.
Impact
Picci et al., Bologna, Italy. In J Clin Oncol, 2009
The expression of MGST1, the microsomal glutathione S-transferase (GST), was found to clearly predict EWS prognosis.
Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores.
GeneRIF
Aniya et al., Okinawa, Japan. In Toxicol Appl Pharmacol, 2009
These results indicate that mitochondrial membrane glutathione transferase in the outer mitochondrial membrane is activated by gallic acid, which may contribute to mitochondrial permeability transition pore formation.
Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria.
GeneRIF
Aniya et al., Okinawa, Japan. In Toxicol Appl Pharmacol, 2008
Results indicate that mtMGST1 is activated through mixed disulfide bond formation that contributes to cytochrome c release from mitochondria through the MPT pore.
Glutathione transferases.
Review
Impact
Jowsey et al., Dundee, United Kingdom. In Annu Rev Pharmacol Toxicol, 2004
This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG.
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