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MHC class I polypeptide-related sequence A

MICA, HLA class I antigen
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (from NCBI)
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Top mentioned proteins: NKG2D, MHC, CAN, HAD, HLA-B
Papers using MICA antibodies
Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells
Supplier
Ridley Anne J. et al., In The Journal of Cell Biology, 1995
... growth supplement, bromodeoxyuridine (BrdU), cytochalasin D, 2,3-butanedione 2-monoxime, TRITC-phalloidin, 2,2′-azino-bis(3-ethylbenz-thiazoline-6-sulphonic acid), and mouse monoclonal anti–human HLA class I antigen antibody (Sigma Chemical Co.); TNF-α (Insight Biotechnology); mouse monoclonal anti-CD45 and ...
Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.
Supplier
Hill Ann B., In PLoS Pathogens, 1985
... U373 cells stably expressing the NKG2D ligands ULBP1, ULBP2, or ULBP3, or MICA or MICB were generated by retroviral transduction using the vector, pLNCX (Clontech, Mountain View, CA) ...
Papers on MICA
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients.
New
Molina et al., Santiago, Chile. In Oncol Rep, Jan 2016
In the present study, MICA and MICB expression was analyzed, by flow cytometry, in 23 and 20 pairs of gastric tumor and adjacent non-neoplasic gastric mucosa, respectively.
[An immunological approach to acute myeloid leukaemia].
New
Pérez-Martínez et al., Madrid, Spain. In An Pediatr (barc), Dec 2015
The mean fluorescence intensities of HLA-I, MICA/B and ULBP1-4, ligands for NK cell receptors, were also analysed in ten new diagnosed leukaemia cases, five myeloid and five lymphoid.
Impact of NK cells on chronic hepatitis C and hepatocellular carcinoma.
Review
New
Takehara et al., Suita, Japan. In Hepatol Res, Dec 2015
Recently the role of MHC class I-related chain A (MICA), a human ligand of NKG2D, has attracted attention in the development of HCC.
The immunogenetics of Psoriasis: A comprehensive review.
Review
New
Bowcock et al., New York City, United States. In J Autoimmun, Nov 2015
These genes span an array of functions that involve antigen presentation (HLA-Cw6, ERAP1, ERAP2, MICA), the IL-23 axis (IL12Bp40, IL23Ap19, IL23R, JAK2, TYK2), T-cell development and T-cells polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1), and negative regulators of immune responses (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1).
Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease. A meta-analysis.
Review
New
Song et al., Seoul, South Korea. In Z Rheumatol, Oct 2015
OBJECTIVE: The purpose of this work was to investigate whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to Behcet's disease (BD).
NKG2D Receptor and Its Ligands in Host Defense.
Review
New
Lanier, San Francisco, United States. In Cancer Immunol Res, Jun 2015
Although NKG2D is encoded by a highly conserved gene (KLRK1) with limited polymorphism, the receptor recognizes an extensive repertoire of ligands, encoded by at least eight genes in humans (MICA, MICB, RAET1E, RAET1G, RAET1H, RAET1I, RAET1L, and RAET1N), some with extensive allelic polymorphism.
MHC I-related chain a expression in gastric carcinoma and the efficacy of immunotherapy with cytokine-induced killer cells.
Ye et al., Fuzhou, China. In Am J Cancer Res, 2014
Previous studies showed that cell signaling through MHC I-related Chain A (MICA)-Natural killer group 2, member D (NKG2D) results in CIK cell activation leading to cytolytic activities against tumor cells.
Regulated Control of the Assembly and Diversity of LPS by Noncoding sRNAs.
Review
Raina et al., Gdańsk, Poland. In Biomed Res Int, 2014
LPS composition is highly heterogeneous and dynamically altered upon stress and other challenges in the environment because of the transcriptional activation of RpoE regulon members and posttranslational control by RpoE-regulated Hfq-dependent RybB and MicA sRNAs.
Quantification of anti-sperm antibody and soluble MICA/MICB levels in the serum of infertile people of the Li ethnic group in China.
Yu et al., Changsha, China. In Int J Clin Exp Med, 2014
OBJECTIVE: To investigate the presence of anti-sperm antibodies (AsAb) and the correlation between AsAb positivity and the expression of soluble major histocompatibility complex class I chain-related A and B (sMICA or sMICB) in the sera of infertile people of the Li nationality from Hainan, China.
Expression of MICA in oral squamous carcinoma cells and its effect on NK cells.
Liu et al., Fuzhou, China. In Int J Clin Exp Med, 2014
OBJECTIVE: This study aims to observe the expression of MHC-class I chain related protein A (MICA) in oral squamous carcinoma cell and explore its effects on NK cells.
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
Impact
Matsuda et al., Tokyo, Japan. In Nat Genet, 2011
We found a previously unidentified locus in the 5' flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 × 10(-13), odds ratio = 1.39) to be strongly associated with HCV-induced HCC.
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D.
Impact
Mandelboim et al., Jerusalem, Israel. In Nat Immunol, 2008
MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D.
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis.
Impact
Girardi et al., London, United Kingdom. In Nat Immunol, 2008
The self-encoded ligands MICA (human) and Rae-1 (mouse) for the cytotoxic lymphocyte activating receptor NKG2D are highly expressed in carcinomas and inflammatory lesions and have been linked to immunosurveillance and graft rejection.
A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase.
GeneRIF
Mason et al., Boston, United States. In Biochem J, 2007
Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA]
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.
Impact
Spies et al., Seattle, United States. In Nature, 2007
However, many progressing tumours in humans counter this anti-tumour activity by shedding the soluble major histocompatibility complex class-I-related ligand MICA, which induces internalization and degradation of NKG2D and stimulates population expansions of normally rare NKG2D+CD4+ T cells with negative regulatory functions.
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance.
Impact
Hayday et al., London, United Kingdom. In Nat Immunol, 2005
Upregulation of the inducible gene products MICA (human) and Rae-1 (mouse) may promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D on natural killer (NK) cells and T cells.
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