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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Major histocompatibility complex, class I, E

MHC
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD4, CD8, V1a, HAD
Papers using MHC antibodies
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
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Brooks David G. et al., In The Journal of Experimental Medicine, 2009
... Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral ...
Semiquantitation of mouse dendritic cell migration in vivo using cellular MRI
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Hu Qingang et al., In International Journal of Nanomedicine, 2008
... Breda, the Netherlands), recombinant murine granulocyte-macrophage colony-stimulating factor, recombinant murine interleukin-4, CD11c, B7-1 (CD80), B7-2(CD86), MHC II, and chemokine receptor 7 (eBioscience, San Diego, CA), tumor ...
Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice.
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Zhang Xiao-Rong et al., In Molecular Vision, 2007
... anti-mouse CD80 (clone 16–10A1) and CD3 (clone 145–2C11), FITC-conjugated rat anti-mouse CD86 (clone GL1) and MHC II(clone M5/114.15.2), and the respective isotype-matched antibodies were purchased from eBioscience (San Diego, CA) ...
CD36 deficiency rescues lipotoxic cardiomyopathy
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Peng Tianqing, In PLoS ONE, 2006
... ) mice and male MHC-PPARα transgenic mice (404-3) in C57BL/6J ...
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration
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Burridge Keith et al., In The Journal of Cell Biology, 2005
... mAbs against Rac1, Cdc42, and MHC class I (MHC-A, -B, and -C) were purchased from BD Biosciences.
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Papers on MHC
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.
New
Impact
Chen et al., New York City, United States. In Nature, Feb 2016
UNASSIGNED: Cellular immunity against viral infection and tumour cells depends on antigen presentation by major histocompatibility complex class I (MHC I) molecules.
MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.
New
Dinarello et al., Milano, Italy. In Proc Natl Acad Sci U S A, Feb 2016
Autoimmune vitiligo is strongly associated with the MHC class II region.
Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo.
New
Spritz et al., Milano, Italy. In Proc Natl Acad Sci U S A, Feb 2016
Vitiligo risk associated with the MHC class I region thus derives from combined quantitative and qualitative phenomena: a SNP haplotype in a transcriptional regulator that induces gain-of-function, elevating expression of HLA-A RNA in vivo, in strong linkage disequilibrium with an HLA-A allele that confers *02:01 specificity.
A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature.
New
Impact
Malissen et al., Gent, Belgium. In Immunity, Feb 2016
emphasized that even by focusing on CD11c(+)MHC II(+) cells, this model yields a mixed bag of myeloid cells that derive from both common dendritic cell (DC) precursors and common monocyte precursors and showed gene-expression profiles distantly mimicking those expressed by their in vivo counterparts.
MAIT cells in autoimmunity, immune mediated diseases and airways disease.
Review
New
Hinks, Melbourne, Australia. In Immunology, Feb 2016
UNASSIGNED: Mucosal associated invariant T (MAIT) cells are a novel class of innate-like T cells, expressing a semi-invariant T cell receptor and able to recognize small molecules presented on the non-polymorphic MHC-related protein 1.
ESCRT-III on endosomes: new functions, new activation pathway.
Review
New
Woodman, Manchester, United Kingdom. In Biochem J, Feb 2016
They show that ubiquitin-dependent sorting of major histocompatibility complex (MHC) class I to the MVB requires the central ESCRT-III complex but does not involve either ESCRT-II or functional links between ESCRT-II and ESCRT-III.
Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.
Review
New
Taylor et al., Duarte, United States. In Poult Sci, Feb 2016
Among these, the best known is the polymorphic major histocompatibility complex-B ( MHC-B: ) region containing genes for classical peptide antigen presentation.
T Cell Epitope Peptide Therapy for Allergic Diseases.
Review
New
Rolland et al., Melbourne, Australia. In Curr Allergy Asthma Rep, Jan 2016
Careful selection of dominant T cell epitope peptides of major allergens that display degeneracy for binding to a wide array of MHC class II molecules allows induction of clinical and immunological tolerance to allergen in a refined treatment strategy.
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
New
Impact
Garcia et al., Stanford, United States. In Nat Immunol, Jan 2016
The T cell antigen receptor (TCR)-peptide-major histocompatibility complex (MHC) interface is composed of conserved and diverse regions, yet the relative contribution of each in shaping recognition by T cells remains unclear.
Chemical and microbial properties of shidal, a traditional fermented fish of Northeast India.
New
Bhaskar et al., India. In J Food Sci Technol, Jan 2016
Poly acrylamide gel electrophoretic study of protein revealed disappearance of myosin head chain (MHC) in the dry puntius fish (raw material of shidal).
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.
New
Impact
Rudensky et al., New York City, United States. In Nature, Jan 2016
Precursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and major histocompatibility complex (MHC) undergo positive selection and differentiate into naive T cells expressing a highly diverse self-MHC-restricted TCR repertoire.
MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.
New
Gendler et al., Scottsdale, United States. In Plos One, Dec 2015
Failure to revaccinate post challenge was associated with down-regulated tumor MUC1 and MHC molecules.
MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
New
Impact
Tokunaga et al., Tokyo, Japan. In Nat Med, Dec 2015
MARCH8 downregulates several host transmembrane proteins, including major histocompatibility complex (MHC)-II, CD86, interleukin (IL)-1 receptor accessory protein, TNF-related apoptosis-inducing ligand (TRAIL) receptor 1 and the transferrin receptor.
Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway.
New
Cao et al., Xi'an, China. In J Geriatr Cardiol, Nov 2015
Elevated amount of α-myosin heavy chain (α-MHC) and cardiac troponin I (cTn I) positive cells were detected by immunofluorescence staining and flow cytometry analysis in CT-1 group.
Natural Killer Cell Recognition of Melanoma: New Clues for a More Effective Immunotherapy.
Review
Solana et al., Cáceres, Spain. In Front Immunol, 2014
However, melanoma cells frequently escape to CD8 T cell recognition by the down-regulation of major histocompatibility complex (MHC) class I molecules.
HLA-E contributes to an immune-inhibitory phenotype of glioblastoma stem-like cells.
GeneRIF
Eisele et al., Zürich, Switzerland. In J Neuroimmunol, 2012
we investigate the contribution of the non-classical MHC molecule HLA-E to the immunosuppressive phenotype of glioma-initiating cells
Genetic polymorphisms inside and outside the MHC improve prediction of AS radiographic severity in addition to clinical variables.
GeneRIF
Mulero et al., Spain. In Rheumatology (oxford), 2012
Prediction of radiographic severity in Ankolysing Spondylitis based on clinical variables can be significantly improved by including Single Nucleotide Polymorphisms both inside and outside the MHC region
Characterization of HLA-E polymorphism in four distinct populations in Mainland China.
GeneRIF
Tian et al., Changsha, China. In Tissue Antigens, 2012
these data unraveled the peculiarity in terms of HLA-E allelic and haplotypic repertoire in four main ethnic groups in Mainland China, findings shown here are valuable for future studies of the potential role of HLA-E in allogeneic organ transplantation a
Human leukocyte antigen E in human cytomegalovirus infection: friend or foe?
Review
GeneRIF
Jiang et al., Wuxi, China. In Acta Biochim Biophys Sin (shanghai), 2012
Studies indicate that HLA-E interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function.
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness.
GeneRIF
Bernstein et al., San Diego, United States. In Mol Biol Cell, 2012
The abnormalities observed in myosin function and muscle ultrastructure likely contribute to muscle weakness observed in our flies and patients.
More papers using MHC antibodies
Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis
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Cho Myeong-Chan et al., In Korean Circulation Journal, 2004
... Purity of rCMCs was more than 98% in morphometric analysis, and immunohistochemical stating with MHC (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells
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Steinman Ralph M. et al., In The Journal of Experimental Medicine, 2001
... OVA-specific, MHC class II–restricted, TCR transgenic mice were DO11.10 (H-2 ...
Transdifferentiation of polymorphonuclear neutrophils: acquisition of CD83 and other functional characteristics of dendritic cells
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Foster Thomas H. et al., In Theranostics, 2000
... Major histocompatibility complex class II cells were labeled with antibodies against MHC-II (1.5 μg; Clone M5/114.15.2, Biolegend).
Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits
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Sonnenberg Arnoud et al., In The Journal of Cell Biology, 1999
... respectively) were from Santa Cruz Biotechnology, Inc.; mouse anti-HA (12CA5) were from Boehringer; mouse anti-sarcomeric MHC (MF20) were from the Developmental Studies Hybridoma Bank; and rabbit and mouse anti-GFP (B34) were from CLONTECH Laboratories, Inc ...
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
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Yang Xiao et al., In Cell Research, 1999
... were bred with α-MHC-Cre transgenic mice, in which the ...
Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study
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Lakka S S et al., In British Journal of Cancer, 1998
... factor receptor, fibroblast growth factor receptor (FGFR), PDGFR, VEGFR2, CD31, MMP-9 and major histocompatibility complex (MHC) class-I (Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
Antiviral CD4+ memory T cells are IL-15 dependent
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Surh Charles D. et al., In The Journal of Experimental Medicine, 1998
... Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral ...
Regulation of macrophage phagocytosis of apoptotic cells by cAMP.
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Neyrolles Olivier, In PLoS ONE, 1997
... All experiments were conducted using 2-mo-old virgin female C57BL/6 mice or ovalbumin (OVA)-specific, MHC II-restricted, T-cell-receptor transgenic mice (OT-II mice) ...
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
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Serhan Charles N. et al., In The Journal of Experimental Medicine, 1994
... I-MHC binding peptide was prepared by Phoenix Pharmaceuticals, Inc ...
Sunburn and p53 in the onset of skin cancer
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Vogel Jonathan C et al., In The Journal of Investigative Dermatology, 1993
... was performed using standard techniques with the following primary antibodies: pancytokeratin (Dako, clone AE1/3), Mouse MHC class I (AbD Serotec, clone 2G5), Human HLA ...
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