RML prions act through Mahogunin and Attractin-independent pathways.
Great Falls, United States. In Prion, 2013
Mahogunin ring finger-1 (Mgrn1) and Attractin (Atrn) null mutant mice accumulate vacuoles throughout the brain that appear very similar to those associated with prion disease, but they do not accumulate the protease-resistant scrapie form of the prion protein or become sick.
The ubiquitin-proteasome system in spongiform degenerative disorders.
Atlanta, United States. In Biochim Biophys Acta, 2008
The link between aberrant ubiquitination and spongiform neurodegeneration has been strengthened by the discovery that a null mutation in the E3 ubiquitin-protein ligase mahogunin ring finger-1 (Mgrn1) causes an autosomal recessively inherited form of spongiform neurodegeneration in animals.
Biology of epidermal and hair pigmentation in cattle: a mini-review.
Ch'ŏnan, South Korea. In Vet Dermatol, 2007
The switching between the syntheses of melanin components depends on several genes like melanocortin-1receptor gene (MC1r) - also known as melanocyte-stimulating hormone receptor gene (MSHr)-, agouti (A), attractin (Atrn) and mahogunin (Mgrn1).