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Matrix Gla protein

MGP, matrix Gla protein
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: ACID, Osteocalcin, CAN, HAD, osteopontin
Papers on MGP
Functional characterization of Mammary Gland Protein-40, a chitinase-like glycoprotein expressed during mammary gland apoptosis.
Mohanty et al., Karnāl, India. In Apoptosis, Feb 2016
MGP-40 is a chitinase-like protein which is over expressed during mammary gland involution.
The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease.
Vermeer et al., Plzeň, Czech Republic. In Int J Cardiol, Feb 2016
BACKGROUND: Matrix Gla protein (MGP) is a natural inhibitor of tissue calcification.
Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and non-bleeding disorders.
Stafford et al., Chapel Hill, United States. In Blood, Feb 2016
Here we report the identification and characterization of novel GGCX mutations in a patient with both severe cerebral bleeding disorder and comorbid Keutel syndrome, a non-bleeding malady caused by functional defects of matrix Gla protein (MGP).
Unilateral Anterior Crossbite Induces Aberrant Mineral Deposition in Degenerative Temporomandibular Cartilage in Rats.
Wang et al., Xi'an, China. In Osteoarthritis Cartilage, Jan 2016
The expression of mineralization inhibitors, NPP1, ANK, CD73, and MGP was decreased from 2-8 weeks post-UAC, so were the chondrogenic markers, Col-2, Col-X and aggrecan.
Warfarin and Vascular Calcification.
Goldhaber et al., Boston, United States. In Am J Med, Jan 2016
This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate gla protein (MGP).
Abdominal aortic calcification: A reappraisal of epidemiological and pathophysiological data.
Szulc, Lyon, France. In Bone, Jan 2016
Vitamin K-dependent proteins protect vascular tunica media against formation of calcified deposits (matrix GLA protein, GLA-rich protein) and against VSMC apoptosis (Gas6).
Measurement of plasma vitamin K1 (phylloquinone) and K2 (menaquinones-4 and -7) using HPLC-tandem mass spectrometry.
Kema et al., In Clin Chem Lab Med, Jan 2016
Functional vitamin K insufficiency was defined as plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) >500 pmol/L.
Development of multigrain premixes-its effect on rheological, textural and micro-structural characteristics of dough and quality of biscuits.
Semwal et al., Mysore, India. In J Food Sci Technol, Dec 2015
Four different Multigrain Premixes (MGPs) namely MGP I, MGP II, MGP III, MGP IV were developed to select the best premix for preparation of biscuits based on nutritional value and biscuit quality.
Long-term warfarin therapy and biomarkers for osteoporosis and atherosclerosis.
Ako et al., Sagamihara, Japan. In Bba Clin, Dec 2015
Vitamin K-dependent matrix Gla protein (MGP) has been known as a potent inhibitor of arterial calcification and osteoporosis.
The role of carbonic anhydrase in the pathogenesis of vascular calcification in humans.
Martínez-Rodríguez et al., Ferrol, Spain. In Atherosclerosis, Jul 2015
In human tissues, carbonic anhydrase is implicated in calcification processes either directly by facilitating calcium carbonate deposition which in turn serves to facilitate calcium phosphate mineralization, or indirectly via its action upon γ-glutamyl-carboxylase, a carboxylase that enables the biological activation of proteins involved in calcification, such as matrix Gla protein, bone Gla protein, and Gla-rich protein.
[Vascular Calcification - Pathological Mechanism and Clinical Application - . Role of vascular smooth muscle cells in vascular calcification].
Kurabayashi, Japan. In Clin Calcium, May 2015
By using a genetic fate mapping strategy, VSMC of the vascular media give rise to the majority of the osteochondrogenic precursor- and chondrocyte-like cells observed in the calcified arterial media of MGP (- / -) mice.
Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health.
Maresz, Kraków, Poland. In Integr Med (encinitas), Feb 2015
An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls.
Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.
Hultström et al., Bergen, Norway. In Plos One, 2014
25 genes were upregulated in Mmp2+/+ OK compared to Mmp2+/+ CL: Adamts1, -2, Col1a1, -2, -3a1, -4a1, -5a1, -5a2, Dcn, Fbln1, -5, Fmod, Fn1, Itga2, Loxl1, Mgp, Mmp2, -3, Nid1, Pdgfb, Spp1, Tgfb1, Timp2, Trf, Vim.
Role of matrix Gla protein in angiotensin II-induced exacerbation of vascular calcification.
Agrawal et al., Omaha, United States. In Am J Physiol Heart Circ Physiol, 2012
Angiotensin II exacerbates vascular calcification through activation of transcription factors, and regulation of MGP and inflammatory cytokine expression in vascular smooth muscle cells.
Matrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis.
Neogi et al., Boston, United States. In J Rheumatol, 2011
There may be an association between hand osteoarthritis and genetic polymorphism at the matrix Gla protein (MGP) locus that is not reflected by total MGP serum concentrations.
Matrix Gla protein deficiency causes arteriovenous malformations in mice.
Boström et al., Los Angeles, United States. In J Clin Invest, 2011
Mgp gene deletion may have a role in arteriovenous malformations
[The frequency of allelic polymorphism of matrix Gla-protein gene in acute coronary syndrome patients].
Ataman et al., In Fiziol Zh, 2010
MGP A/A variant of MGP promoter G-7-->A polymorphism is a risk factor of ACS in Ukrainian population.
Serum matrix Gla protein concentrations in patients with mild and severe acute pancreatitis.
Kulig et al., Kraków, Poland. In Clin Lab, 2010
MGP level correlated negatively with proinflammatory cytokines & acute phase proteins in acute pancreatitis, & positively with lipase, fetuin A, & albumin, indicating a possible role in calcium & phosphate metabolism disturbances in AP.
Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome.
Chung et al., London, United Kingdom. In Nat Genet, 1999
MGP was a candidate on the basis of its localization to this chromosomal region and the known function of its protein.
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.
Karsenty et al., Houston, United States. In Nature, 1997
A candidate molecule is matrix GLA protein (Mgp), a mineral-binding ECM protein synthesized by vascular smooth-muscle cells and chondrocytes, two cell types that produce an uncalcified ECM.
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