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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate receptor, metabotropic 1

mGluR1, metabotropic glutamate receptor, metabotropic glutamate receptor 1
may play a role in synaptic transmission; may modulate perception of pain in arthritis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: metabotropic glutamate receptor, mGluR, CAN, ACID, V1a
Papers using mGluR1 antibodies
Intracortical excitation of spiny neurons in layer 4 of cat striate cortex in vitro
Supplier
Sherman S. Murray et al., In Frontiers in Systems Neuroscience, 1998
... To block the group 1 mGluRs, LY367385 (20 μM) for mGluR1 and MPEP (30 μM) for mGluR5 (TOCRIS, Ellisville, MO, USA) were ...
Papers on mGluR1
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.
New
Logothetis et al., Richmond, United States. In Pflugers Arch, Feb 2016
UNASSIGNED: We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011-1023, 2011) results in inverse cross-signaling, where for either receptor, strong agonists suppress and inverse agonists potentiate the signaling of the partner receptor.
The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats.
New
Gorji et al., Tehrān, Iran. In Mol Neurobiol, Feb 2016
UNASSIGNED: Modulatory function of metabotropic glutamate type 1 (mGlu1) receptors plays a crucial role in the pathophysiology of some neurological disorders, including schizophrenia and epilepsy.
Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.
Review
New
Tipre et al., Stony Brook, United States. In Eur J Nucl Med Mol Imaging, Feb 2016
UNASSIGNED: This review summarizes the contributions by various teams of scientists in assessing the metabotropic glutamate receptor 5 (mGluR5) as a biomarker in neuropsychiatric disorders and diseases.
New targets for rapid antidepressant action.
Review
New
Zarate et al., Bethesda, United States. In Prog Neurobiol, Jan 2016
This article reviews the clinical evidence supporting the use of novel glutamate receptor modulators with direct affinity for cognate receptors: (1) non-competitive NMDA receptor antagonists (ketamine, memantine, dextromethorphan, AZD6765); (2) subunit (GluN2B)-specific NMDA receptor antagonists (CP-101,606/traxoprodil, MK-0657); (3) NMDA receptor glycine-site partial agonists (GLYX-13); and (4) metabotropic glutamate receptor (mGluR) modulators (AZD2066, RO4917523/basimglurant).
Signal integration by Ca(2+) regulates intestinal stem-cell activity.
New
Impact
Jasper et al., Novato, United States. In Nature, Jan 2016
The metabotropic glutamate receptor (mGluR) is required in ISCs for this response, and for an associated modulation of cytosolic Ca(2+) oscillations that results in sustained high cytosolic Ca(2+) concentrations.
mGlu5, Dopamine D2 and Adenosine A2A Receptors in L-DOPA-Induced Dyskinesias.
Review
New
Di Paolo et al., Québec, Canada. In Curr Neuropharmacol, Jan 2016
An approach to manage LID is to add to L-DOPA specific agents to reduce dyskinesias such as metabotropic glutamate receptor (mGlu receptor) drugs.
The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder.
New
Hakonarson et al., Seattle, United States. In Sci Rep, Dec 2015
While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved in the pathophysiology of Autism Spectrum Disorder (ASD), Fragile X Syndrome and Tuberous Sclerosis, the role of other mGluRs and their associated signaling network genes in syndromic ASD is unknown.
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways.
New
Impact
Araque et al., Madrid, Spain. In Science, Sep 2015
Likewise, astrocyte subpopulations selectively regulated homotypic synapses through metabotropic glutamate receptor activation.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.
The influence of glutamatergic receptor antagonists on biochemical and ultrastructural changes in myelin membranes of rats subjected to experimental autoimmune encephalomyelitis.
Sulkowski et al., Warsaw, Poland. In Folia Neuropathol, 2014
The aim of the study was to test the effects of the glutamatergic receptor antagonists amantadine and memantine (antagonists of NMDA receptors), LY 367384 (an antagonist of mGluR1), and MPEP (an mGluR5 antagonist) on the development of neurological symptoms in immunized animals, morphological changes in cerebral myelin, and expression of mRNA of the principal myelin proteins PLP, MBP, MOG, MAG, and CNPase.
Effects of mGluR5 positive and negative allosteric modulators on brain damage evoked by hypoxia-ischemia in neonatal rats.
Łazarewicz et al., Warsaw, Poland. In Folia Neuropathol, 2014
In the present study, we examined the effects of negative and positive allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), fenobam and ADX47273, respectively, on brain damage induced by hypoxia-ischemia (H-I) in 7-day-old rats.
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Impact
Marshall et al., Welwyn Garden City, United Kingdom. In Nature, 2014
Metabotropic glutamate receptor 5 is of considerable interest as a drug target in the treatment of fragile X syndrome, autism, depression, anxiety, addiction and movement disorders.
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.
Impact
Turecki et al., Montréal, Canada. In Nat Med, 2014
Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 (GRM4) and predicts antidepressant response at baseline.
Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
Impact
Kano et al., Tokyo, Japan. In Science, 2014
The effect of Sema7A involves signaling by metabotropic glutamate receptor 1, a canonical pathway for climbing fiber synapse elimination.
mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes.
GeneRIF
Mikeladze et al., Tbilisi, Georgia. In Mol Immunol, 2012
Normal, non-mutated CFTR, as well as mutated forms of CFTR were associated with metabotropic mGluR1.
Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt.
GeneRIF
Kennedy et al., Toronto, Canada. In Psychiatry Res, 2012
This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248.
P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje cells.
GeneRIF
Kapfhammer et al., Basel, Switzerland. In Eur J Neurosci, 2012
Data suggest that both T-type and P/Q-type Ca(2+) channels, but not TRPC3 or other Ca(2+) -permeable channels, are involved in mGluR1 and PKC signaling leading to the inhibition of dendritic growth in cerebellar Purkinje cells.
N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity.
GeneRIF
Zhang et al., Beijing, China. In Plos One, 2011
NAC might be a potential therapeutics targeting for group I mGlus activation in the treatment of PD.
Deleterious GRM1 mutations in schizophrenia.
GeneRIF
Kalaydjieva et al., Perth, Australia. In Plos One, 2011
Deleterious GRM1 mutations are associated with schizophrenia.
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