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CTAGE family, member 5

MGEA6, MGEA11, MEA6, CTAGE5
The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
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Top mentioned proteins: SET, Phosphogluconate Dehydrogenase, OUT, USP9Y, Tec
Papers on MGEA6
High frequency of the SDK1:AMACR fusion transcript in Chinese prostate cancer.
Ren et al., Hangzhou, China. In Int J Clin Exp Med, 2014
Four high-frequency prostate cancer (CaP) specific fusion genes, SDK1:AMACR, RAD50:PDLIM4, CTAGE5:KHDRBS3 and USP9Y:TTTY15 have been reported in Chinese CaP samples through a transcriptome sequencing study.
Analysis of the CTAGE5 P521A variation with the risk of familial idiopathic basal ganglia calcification in an Iranian population.
Khorram Khorshid et al., Tehrān, Iran. In J Mol Neurosci, 2013
Recently, a heterozygous variation (C>G, P521A) at exon 20 of the human cutaneous T cell lymphoma-associated antigen 5 (CTAGE5) gene was found in all patients of the affected large American family linked to IBGC1 (14q11.2-21.3).
Prevalence and progression of basal ganglia calcification and its pathogenic mechanism in patients with idiopathic hypoparathyroidism.
Das et al., New Delhi, India. In Clin Endocrinol (oxf), 2012
METHOD: Clinical, biochemical characteristics and a meningioma-expressed antigen-6 (MGEA6) gene polymorphism were analysed in 145 patients with IH, recruited since 1998, to determine the factors associated with BGC.
RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings.
Sun et al., Shanghai, China. In Cell Res, 2012
Notably, two novel gene fusions, CTAGE5-KHDRBS3 (20/54=37%) and USP9Y-TTTY15 (19/54=35.2%),
cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.
GeneRIF
Katada et al., Tokyo, Japan. In Mol Biol Cell, 2011
cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII
Population and computational analysis of the MGEA6 P521A variation as a risk factor for familial idiopathic basal ganglia calcification (Fahr's disease).
GeneRIF
Oliveira et al., Recife, Brazil. In J Mol Neurosci, 2011
population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings
Evaluation of T7 and lambda phage display systems for survey of autoantibody profiles in cancer patients.
Linē et al., Rīga, Latvia. In J Immunol Methods, 2008
T7 phage display system showed greater sensitivity for the detection of antibodies against members of CTAG, MAGEA and GAGE families, both systems showed equal performance in detecting the reactivity against MAGEC and SSX2 while only lambdaKM8 allowed the detection of anti-CTAGE5 antibodies.
Analysis of candidate genes at the IBGC1 locus associated with idiopathic basal ganglia calcification ("Fahr's disease").
Geschwind et al., Los Angeles, United States. In J Mol Neurosci, 2006
During the sequencing process, we identified a heterozygous nonsynonymous single nucleotide polymorphism (exon 20 of the MGEA6/c-TAGE gene) shared by the affected and not present in the controls.
cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.
Eichmüller et al., Heidelberg, Germany. In J Invest Dermatol, 2003
Rapid amplification of cDNA ends and DNA screening led to five new members of the cTAGE gene family belonging to four different genes, two of which were differentially spliced (cTAGE-1/2 and cTAGE-5).
MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies.
Meese et al., Homburg, Germany. In Oncogene, 2002
Previously, we have cloned the cDNAs for the meningioma expressed antigen 6 (MGEA6) and its splice variant MGEA11.
The MGEA6 multigene family has an active locus on 14q and at least nine pseudogenes on different chromosomes.
Meese et al., Homburg, Germany. In Genomics, 2001
The meningioma expressed antigen-6 (MGEA6) was originally identified as an immunogenic antigen in meningioma patients.
cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients.
Meese et al., Homburg, Germany. In Hum Mol Genet, 1997
The longest open reading frame was found to be 2412 bp encoding an immunoreactive antigen termed meningioma expressed antigen 6 (MEA6).
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