Pancholi et al., Columbus, United States. In Mol Microbiol, Aug 2015
SP-PTP also differentially regulates the expression of ∼50% of the total GAS genes, including several virulence genes potentially through the two-component regulators, CovR, WalR and PTS/HPr regulation of Mga.
Kumaraswami et al., Houston, United States. In Infect Immun, Jun 2015
Whole-genome sequencing analysis of ∼800 strains of group A Streptococcus (GAS) found that the gene encoding the multiple virulence gene regulator of GAS (mga) is highly polymorphic in serotype M59 strains but not in strains of other serotypes.
Olsen et al., Monterrey, Mexico. In Am J Pathol, Feb 2015
Whole-genome sequencing of approximately 800 serotype M59 group A Streptococcus strains, recovered during an outbreak of severe invasive infections across North America, identified a disproportionate number of SNPs in the gene encoding multiple gene regulator of group A Streptococcus (mga).
Papaioannou et al., New York City, United States. In Development, 2015
The dual specificity T-box/basic-helix-loop-helix-zipper transcription factor Mga is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantation mouse embryo, but its function has not been investigated previously.
Musser et al., Houston, United States. In Infect Immun, 2013
We previously reported that two epidemiologically unassociated serotype M3 group A Streptococcus (GAS) carrier strains had an identical 12-bp deletion in the promoter of the gene encoding Mga, a global positive gene regulator.
Goda et al., Shizuoka, Japan. In Mol Nutr Food Res, 2010
investigation of dietary control of Mgam expression in jejunum: high starch diet induces Mgam through mechanism involving increased acetylation of histones and increased binding of CREBBP, CDX2, and HNF1 to Mgam gene
McIver, College Park, United States. In Contrib Microbiol, 2008
The 'stand-alone' regulators Mga, RofA-like proteins (RALPs), and RopB/Rgg control important and diverse virulence regulons in response to growth-related signals and other environmental conditions in GAS.