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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Mucin 7, secreted

MG2, MUC7, MCOLN1, MLIV, mucolipin-1
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, MUC5AC, MUC1
Papers using MG2 antibodies
In defense of the oral cavity: the protective role of the salivary secretions
Supplier
Bobek Libuse A. et al., In The Open Respiratory Medicine Journal, 2005
... ) and MUC7 transgenic mouse tissues ( ...
Papers on MG2
Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV.
New
Slaugenhaupt et al., Omaha, United States. In Am J Pathol, Jan 2016
Mucolipidosis IV is caused by loss-of-function mutations in the MCOLN1 gene, which encodes the transient receptor potential channel protein mucolipin-1.
Scalable synthesis and post-modification of a mesoporous metal-organic framework called NU-1000.
New
Farha et al., Evanston, United States. In Nat Protoc, Jan 2016
The procedure for the preparation of NU-1000 can be scaled up reliably, and it is suitable for the production of 50 g of the tetracarboxylic acid containing organic linker and 200 mg-2.5 g of NU-1000.
Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV.
New
Muallem et al., Bethesda, United States. In Embo Rep, Jan 2016
UNASSIGNED: Mutations in TRPML1 cause the lysosomal storage disease mucolipidosis type IV (MLIV).
Case studies putting the decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping) into practice.
New
Landsiedel et al., Arnhem, Netherlands. In Regul Toxicol Pharmacol, Jan 2016
These are soluble nanomaterials (MG1) whose further hazard assessment should rely on read-across to the dissolved materials, high aspect-ratio nanomaterials (MG2) which could be assessed according to their potential fibre toxicity and passive nanomaterials (MG3) that only elicit effects under pulmonary overload conditions.
Reduced MUC7 mucin sialylation and altered saliva rheology in Sjogren's syndrome associated oral dryness.
New
Flowers et al., London, United Kingdom. In Mol Cell Proteomics, Jan 2016
Saliva is a complicated biological fluid with major constituents including heavily glycosylated mucins MUC5B and MUC7, important for its viscoelastic, hydrating and lubricating properties.
Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases.
Review
New
Negi et al., Bhubaneshwar, India. In Glycoconj J, Nov 2015
In human it is only MUC1 and MUC7 that have mucin domains with less than 40 % serine and threonine which in turn could reduce number of PTS domains.
The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.
Impact
Xu et al., Ann Arbor, United States. In Nat Med, 2014
MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca(2+) channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities.
TRPML2 and mucolipin evolution.
Review
Wiwatpanit et al., Chicago, United States. In Handb Exp Pharmacol, 2013
The TRPML2 protein, encoded by the Mcoln2 gene, is one of the three mucolipins (TRPML1-3), a subset of the TRP superfamily of ion channels.
(68)Ga-Labeled DOTA-conjugated sCCK8[Phe(2)(p-CH2SO3H),Nle(3,6)], a sulfated cholecystokinin 8 (sCCK8) peptide derivative
Review
Chopra, Bethesda, United States. In Unknown Journal, 2013
Two cyclized MG analogs, cyclo-MG1 and cyclo-MG2, were synthesized, labeled with (99m)Tc, and evaluated with single-photon emission computed tomography (SPECT) for the detection of tumors that express CCKR (7).
(111)In-Labeled DOTA-conjugated sCCK8[Phe(2)(p-CH2SO3H),Nle(3,6)], a sulfated cholecystokinin 8 (sCCK8) peptide derivative
Review
Chopra, Bethesda, United States. In Unknown Journal, 2013
Two cyclized MG analogs, cyclo-MG1 and cyclo-MG2, were synthesized, labeled with (99m)Tc, and evaluated with single-photon emission computed tomography (SPECT) for the detection of tumors that express CCKR (7).
Phosphoinositide isoforms determine compartment-specific ion channel activity.
GeneRIF
Xu et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
PI(4,5)P(2) may serve as a negative cofactor for intracellular channels such as TRPML1
(111)In/(68)Ga-Labeled DOTA conjugated cyclo[γ-d-Glu-Ala-Tyr-d-Lys]-Trp-Nle-Asp-Phe-NH2 (cyclo-MG2), a minigastrin analog
Review
Chopra, Bethesda, United States. In Unknown Journal, 2012
Two cyclized MG analogues, cyclo-MG1 (cyclo(1,9)[γ-d-Glu(1),desGlu(2)−(6),d-Lys(9)]MG) and cyclo-MG2 (cyclo(1,9)[γ-d-Glu(1),desGlu(2)−(6),d-Lys(9),Nle(11)]MG) were synthesized, conjugated to metal chelating agents, labeled with (99m)Tc and evaluated with single photon emission computed tomography (SPECT) for the detection of tumors that express the CCKR (6).
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis.
GeneRIF
Kiselyov et al., Pittsburgh, United States. In J Biol Chem, 2012
an acute siRNA-mediated loss of TRPML1 specifically causes a leak of lysosomal protease cathepsin B (CatB) into the cytoplasm. CatB leak is associated with apoptosis, which can be prevented by CatB inhibition.
Genetic polymorphism of MUC7 in individuals with aggressive or chronic periodontitis.
GeneRIF
Soares et al., Belo Horizonte, Brazil. In J Oral Sci, 2011
expression of different numbers of terminal repeats in this salivary mucin in the oral environment does not interfere with the etiopathogenesis of aggressive or chronic periodontitis
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.
GeneRIF
Xu et al., Ann Arbor, United States. In Nat Commun, 2011
findings show that TRPML1-mediated lysosomal Ca(2 ) release is dramatically reduced in Niemann-Pick disease cells; propose that abnormal accumulation of luminal lipids causes secondary lysosome storage by blocking TRPML1- and Ca(2 )-dependent lysosomal trafficking
[Association of the polymorphism of MUC7 gene encoding the low-molecular-weight mucin MG2 with susceptibility to caries].
GeneRIF
Pol, Szczecin, Poland. In Ann Acad Med Stetin, 2010
The present study did not disclose an association between MUC7*5/*6 and MUC7*6/*6 genotypes and gingival bleeding index.
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells.
Impact
Montell et al., Baltimore, United States. In Cell, 2008
Disruption of the Transient Receptor Potential (TRP) mucolipin 1 (TRPML1) channel results in the neurodegenerative disorder mucolipidosis type IV (MLIV), a lysosomal storage disease with severe motor impairments.
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.
Impact
GeneRIF
Xu et al., Ann Arbor, United States. In Nature, 2008
TRPML1 functions as a Fe(2+) permeable channel in late endosomes and lysosomes
Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial.
Impact
European Organisation for Research and Treatment of Cancer colorectal cancer study group et al., Oxford, United Kingdom. In Lancet, 2003
METHODS: We randomly allocated 290 patients from 16 centres to receive either intravenous chemotherapy (folinic acid 200 mg/m2, fluorouracil bolus 400 mg2 and 22-h infusion 600 mg/m2, day 1 and 2, repeated every 14 days), or IHA chemotherapy designed to be equitoxic (folinic acid 200 mg/m2, fluorouracil 400 mg/m2 over 15 mins and 22-h infusion 1600 mg/m2, day 1 and 2, repeated every 14 days).
Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog.
Impact
Greenwald et al., New York City, United States. In Nat Genet, 2001
Loss of the human mucolipin-1 gene underlies mucolipidosis type IV (MLIV), a lysosomal storage disease that results in severe developmental neuropathology.
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