TRPML2 and mucolipin evolution.
Chicago, United States. In Handb Exp Pharmacol, 2013
The TRPML2 protein, encoded by the Mcoln2 gene, is one of the three mucolipins (TRPML1-3), a subset of the TRP superfamily of ion channels.
(111)In/(68)Ga-Labeled DOTA conjugated cyclo[γ-d-Glu-Ala-Tyr-d-Lys]-Trp-Nle-Asp-Phe-NH2 (cyclo-MG2), a minigastrin analog
Bethesda, United States. In Unknown Journal, 2012
Two cyclized MG analogues, cyclo-MG1 (cyclo(1,9)[γ-d-Glu(1),desGlu(2)−(6),d-Lys(9)]MG) and cyclo-MG2 (cyclo(1,9)[γ-d-Glu(1),desGlu(2)−(6),d-Lys(9),Nle(11)]MG) were synthesized, conjugated to metal chelating agents, labeled with (99m)Tc and evaluated with single photon emission computed tomography (SPECT) for the detection of tumors that express the CCKR (6).