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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Mitofusin 1

Mfn1, mitofusin 1, HR-2
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSG, Utrophin, OPA1, Dynamin I, Fis1
Papers on Mfn1
Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells.
New
Moreira et al., Coimbra, Portugal. In Mol Neurobiol, Feb 2016
The inhibition of PP2A activity also promoted an alteration of the structural and spatial mitochondria network due to upregulation of mitochondrial fission (Drp1 and Fis1) and fusion (Mfn1, Mfn2 and OPA1) proteins, suggesting detrimental changes in mitochondrial dynamics.
GASZ and mitofusin-mediated mitochondrial functions are crucial for spermatogenesis.
New
Wang et al., Shanghai, China. In Embo Rep, Jan 2016
In addition, GASZ interacts with itself at the outer membrane of mitochondria and promotes mitofusion in a mitofusin/MFN-dependent manner.
Dopamine induces mitochondrial depolarization without activating PINK1-mediated mitophagy.
New
Alberio et al., Busto Arsizio, Italy. In J Neurochem, Jan 2016
Nevertheless, mitochondrial network resulted to assume a peculiar morphology with a distinct pattern of OPA1 and MFN1, key regulators of mitochondrial dynamics.
Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling.
New
Ascensão et al., Porto, Portugal. In Mitochondrion, Jan 2016
Mitochondrial dynamics (Mfn1, Mfn2, OPA1 and DRP1) and auto(mito)phagy (LC3II, Beclin1, Pink1, Parkin and p62)-related proteins were measured by semi-quantitative Western blotting.
Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization.
New
Impact
Chan et al., Pasadena, United States. In Cell Metab, Jan 2016
Using in vivo approaches, we find that OXPHOS-dependent fibers, compared to glycolytic fibers, contain elongated mitochondrial networks with higher fusion rates that are dependent on the mitofusins Mfn1 and Mfn2.
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.
New
Lin et al., Tainan City, Taiwan. In Plos Pathog, Dec 2015
Two mitofusins (MFN1 and MFN2), which mediate mitochondrial fusion and participate in the proper function of mitochondria, were cleaved by DENV protease NS2B3.
Analysis of mitochondrial structure and function in the Drosophila larval musculature.
Review
New
Geisbrecht et al., Kansas City, United States. In Mitochondrion, Dec 2015
Mutations in genes that control mitochondrial fission or fusion, such as dynamin-related protein (Drp1), Mitofusins 1 (Mfn1) and 2 (Mfn2), and Optic atrophy 1 (Opa1), result in neuropathies or neurodegenerative diseases.
Physiological roles of mitochondrial fission in cultured cells and mouse development.
Review
New
Ishihara et al., Kurume, Japan. In Ann N Y Acad Sci, Sep 2015
These changes in mitochondrial morphology occur by repeated membrane fusion and fission events, which are regulated by three types of GTPase proteins: OPA1, Mfn1/2, Drp1 in mammalian cells.
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts.
New
Impact
Dorn et al., Saint Louis, United States. In Cell Metab, Mar 2015
We uncovered distinct effects on mitophagy of inhibiting Drp1-mediated mitochondrial fission versus mitofusin-mediated mitochondrial fusion.
Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart.
Review
New
Impact
Dorn et al., Saint Louis, United States. In Cell Metab, Mar 2015
Nevertheless, mitochondrial fission factor Drp1 and fusion factors Mfn1, Mfn2, and Opa1 are abundant and indispensable in adult hearts.
Functional implications of mitofusin 2-mediated mitochondrial-SR tethering.
Review
Walsh et al., Saint Louis, United States. In J Mol Cell Cardiol, 2015
Physical proximity and functional interplay between mitochondria and SR are maintained in part through tethering of these two organelles by the membrane protein mitofusin 2 (Mfn2).
Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population.
Xu et al., Nanchong, China. In Int J Ophthalmol, 2014
AIM: To explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population.
Mitochondrial dynamics in the central regulation of metabolism.
Review
Horvath et al., New Haven, United States. In Nat Rev Endocrinol, 2014
The main proteins implicated in these studies are the mitofusins, Mfn1 and Mfn2, which are regulators of mitochondrial dynamics.
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.
Impact
Horvath et al., New Haven, United States. In Cell, 2013
Interfering with mitochondrial fusion mechanisms in Agrp neurons by cell-selectively knocking down mitofusin 1 (Mfn1) or mitofusin 2 (Mfn2) resulted in altered mitochondria size and density in these cells.
Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner.
GeneRIF
Choi et al., Taejŏn, South Korea. In Cancer Lett, 2012
These results collectively suggest a role for Mfn1 in regulating the activation of Bax on the outer mitochondrial membrane in a GTPase-dependent manner.
Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning.
GeneRIF
Zhou et al., Tianjin, China. In Psychoneuroendocrinology, 2012
Physical exercise is identified as a preventive measure to promote mitochondrial function and expressions of mitofusin, BDNF and antioxidant in brain, so as to protect brain energy metabolism against chronic mild stress.
Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1.
Impact
Moncada et al., London, United Kingdom. In Cell Metab, 2012
Changes in mitochondrial morphology and mass are due to accumulation of OPA1, MFN1, and TFAM, silencing any of which hinders cell proliferation.
High expression of Mfn1 promotes early development of bovine SCNT embryos: improvement of mitochondrial membrane potential and oxidative metabolism.
GeneRIF
Zhang et al., China. In Mitochondrion, 2012
The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.
Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.
GeneRIF
Walsh et al., Boston, United States. In Am J Physiol Heart Circ Physiol, 2012
Data suggest that Mfn-1 deletion in cardiomyocytes confers protection against reactive oxygen species-induced mitochondrial dysfunction.
Multi-patterned dynamics of mitochondrial fission and fusion in a living cell.
GeneRIF
Long et al., Beijing, China. In Plos One, 2011
Knock-out of mitofusin protein Mfn1 increased the frequency of mitochondrial fission with increased lifetime of unpaired events whereas deletion of both Mfn1 and Mfn2 resulted in an instable dynamics.
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