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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitochondrial fission factor

MFF, mitochondrial fission factor
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Top mentioned proteins: Utrophin, Dynamin I, Fis1, CAN, V1a
Papers on MFF
Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy.
Haack et al., Salzburg, Austria. In J Med Genet, Feb 2016
Deficiency of a third component (mitochondrial fission factor, MFF) was recently reported in one index patient, rendering MFF another candidate disease gene within the expanding field of mitochondrial and peroxisomal dynamics.
Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity.
Ramachandran et al., Cleveland, United States. In J Biol Chem, Feb 2016
Mitochondrial fission factor (Mff), a tail-anchored membrane protein of the mitochondrial outer membrane that recruits Drp1 to sites of ensuing fission, differentially stimulates the disparate Drp1 isoforms and alleviates the autoinhibitory effect imposed by these sequences on Drp1 function.
Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor.
Mears et al., Cleveland, United States. In J Biol Chem, Feb 2016
One such Drp1 partner protein, mitochondrial fission factor (Mff), is essential for mitochondrial division, but its mechanism of action remains unexplored.
Differential autophagic effects triggered by five different vertebrate iridoviruses in a common, highly permissive mandarinfish fry (MFF-1) cell model.
Dong et al., Guangzhou, China. In Fish Shellfish Immunol, Jan 2016
UNASSIGNED: Autophagy of five vertebrate iridoviruses, including one megalocytivirus (infectious spleen and kidney necrosis virus, ISKNV) and four ranaviruses (Chinese giant salamander iridovirus, CGSIV; Tiger frog virus, TFV; Grouper iridovirus, GIV; and Largemouth bass virus, LMBV) were investigated in a common, highly permissive mandarinfish fry (MFF-1) cell model.
The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1.
Chan et al., Pasadena, United States. In Mol Biol Cell, Jan 2016
The Drp1 receptor Mff is a major regulator of mitochondrial fission, and its overexpression results in increased fission.
Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization.
Chan et al., Pasadena, United States. In Cell Metab, Jan 2016
The domain dimensions are dependent on fiber type and are regulated by the mitochondrial dynamics proteins Mfn1, Mfn2, and Mff.
Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites.
Higgs et al., Hanover, United States. In Elife, Dec 2015
Actin filaments bind purified Drp1 and increase GTPase activity in a manner that is synergistic with the mitochondrial protein Mff, suggesting a role for direct Drp1/actin interaction.
Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.
Chan et al., Pasadena, United States. In J Cell Biol, Dec 2015
We addressed this issue by analyzing mice deficient in Mff, a protein important for mitochondrial fission.
Peroxisome homeostasis: Mechanisms of division and selective degradation of peroxisomes in mammals.
Fujiki et al., Fukuoka, Japan. In Biochim Biophys Acta, Nov 2015
In the course of peroxisomal division, peroxisomal morphogenesis is orchestrated by Pex11β, dynamin-like protein 1 (DLP1), and mitochondrial fission factor (Mff).
Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart.
Dorn et al., Saint Louis, United States. In Cell Metab, Mar 2015
Nevertheless, mitochondrial fission factor Drp1 and fusion factors Mfn1, Mfn2, and Opa1 are abundant and indispensable in adult hearts.
Roles of mitochondrial ubiquitin ligase MITOL/MARCH5 in mitochondrial dynamics and diseases.
Yanagi et al., Hachiōji, Japan. In J Biochem, 2014
MITOL plays an important role in the regulation of mitochondrial dynamics including mitochondrial morphology, transport and interaction with ER, at least in part, through the ubiquitinations of mitochondrial fission factor Drp1, microtubule-associated protein 1B and mitofusin2, respectively.
Peroxisome biogenesis in mammalian cells.
Tamura et al., Fukuoka, Japan. In Front Physiol, 2013
Peroxins are divided into three groups: (1) peroxins including Pex3p, Pex16p, and Pex19p, are responsible for peroxisome membrane biogenesis via classes I and II pathways; (2) peroxins that function in matrix protein import; (3) those such as three forms of Pex11p, Pex11pα, Pex11pβ, and Pex11pγ, are involved in peroxisome proliferation where DLP1, Mff, and Fis1 coordinately function.
A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.
Jonas et al., New Haven, United States. In Nat Cell Biol, 2013
Our evidence suggests that, during synaptic stimulation, Bcl-xL translocates to clathrin-coated pits in a calmodulin-dependent manner and forms a complex with the GTPase Drp1, Mff and clathrin.
Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates.
Nistér et al., Stockholm, Sweden. In Cell Mol Life Sci, 2013
We highlight and discuss the mechanisms regulating recruitment of cytosolic Drp1 to the mitochondrial outer membrane by Fis1, Mff, and MIEF1 in mammals and the divergences in regulation of mitochondrial dynamics between yeast and vertebrates.
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.
Wang et al., Dallas, United States. In Cell, 2012
Upon necrosis induction, PGAM5S recruited the mitochondrial fission factor Drp1 and activated its GTPase activity by dephosphorylating the serine 637 site of Drp1.
Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
Demiryurek et al., Gaziantep, Turkey. In Endocr Pathol, 2011
MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells.
van der Bliek et al., Los Angeles, United States. In Mol Biol Cell, 2008
Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes.
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