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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Methylenetetrahydrofolate reductase

methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase
converts 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate; mutations in human may be associated with hyperhomocysteinaemia, and a risk factor for spina bifida in women [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: methylenetetrahydrofolate reductase, HAD, AGE, POLYMERASE, ACID
Papers on methylenetetrahydrofolate reductase
Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with preterm delivery and placental abruption: a systematic review and meta-analysis.
Wu et al., Ningbo, China. In Acta Obstet Gynecol Scand, Feb 2016
INTRODUCTION: The aim of this study was to summarize evidence on the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and odds of preterm delivery and placental abruption.
Lower Extremity Flap Salvage in Thrombophilic Patients: Managing Expectations in the Setting of Microvascular Thrombosis.
Evans et al., Washington, D.C., United States. In J Reconstr Microsurg, Feb 2016
The most common traits were the plasminogen activator inhibitor-1 4G/5G variant (n = 12) and the methylenetetrahydrofolate reductase A1298C (n = 10) and C677T (n = 9) polymorphisms.
Τwo-panel molecular testing for genetic predisposition for thrombosis using multi-allele visual biosensors.
Ioannou et al., Athens, Greece. In Anal Bioanal Chem, Feb 2016
The three most common genetic risk factors for thrombotic disorders are the G1691A mutation in factor V gene (FV Leiden), the G20210Α mutation in prothrombin gene (FII), and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene.
High homocysteine and epistasis between MTHFR and APOE: Association with cognitive performance in the elderly.
Guaita et al., Milano, Italy. In Exp Gerontol, Feb 2016
The impact of high tHcy on different cognitive domains deserves further investigation, as does the role of the C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene.
Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis.
Liu et al., Beijing, China. In J Stroke Cerebrovasc Dis, Feb 2016
To test this hypothesis, we performed a meta-analysis to investigate the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which plays a critical role in modulating plasma homocysteine concentrations, and IS risk.
A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia.
Seedat et al., Cape Town, South Africa. In Schizophr Res, Jan 2016
Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C).
Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility.
Rai et al., Jaunpur, India. In Meta Gene, Dec 2015
There are several evidences supporting the role of 5-10 methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in breast cancer (BC).
Thrombophilia and venous thromboembolism in pregnancy: a meta-analysis of genetic risk.
Zintzaras et al., Providence, United States. In Eur J Obstet Gynecol Reprod Biol, Aug 2015
Three common polymorphic variants, namely Factor V Leiden (FVL), Prothrombin G20210A (PT G20210A) and Methylenetetrahydrofolate Reductase (MTHFR) C677T are candidate genes for venous thromboembolism (VTE) in pregnancy.
Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature.
Cuomo et al., Napoli, Italy. In J Med Case Reports, 2014
He was diagnosed with hyperhomocysteinemia associated with a homozygous C677T mutation of the gene encoding the enzyme methylenetetrahydrofolate reductase.
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis.
Zheng et al., China. In Genet Mol Res, 2014
Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial.
Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer.
Romkes et al., Pittsburgh, United States. In J Clin Oncol, 2011
DNA was isolated from whole blood samples for the detection of polymorphisms in thymidylate synthase, methylenetetrahydrofolate reductase (MTHFR), and VEGF.
Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.
Seymour et al., Leeds, United Kingdom. In J Clin Oncol, 2009
Ten polymorphisms were assessed: thymidylate synthase-enhancer region (TYMS-ER), thymidylate synthase 1494 (TYMS-1494), dihydropyrimidine dehydrogenase (DPYD), methylenetetrahydrofolate reductase (MTHFR), mutL homolog 1 (MLH1), UDP glucuronyltransferase (UGT1A1), ATP-binding cassette group B gene 1 (ABCB1), x-ray cross-complementing group 1 (XRCC1), glutathione-S-transferase P1 (GSTP1), and excision repair cross-complementing gene 2 (ERCC2).
Cervical-artery dissections: predisposing factors, diagnosis, and outcome.
Leys et al., Lille, France. In Lancet Neurol, 2009
In addition to trauma to the neck, other risk factors have been suggested, such as infection, migraine, hyperhomocysteinaemia, and the 677TT genotype of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR 677TT), although evidence is sparse.
Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer.
Groen et al., Amsterdam, Netherlands. In J Clin Oncol, 2009
Polymorphisms of thymidylate synthase, the reduced folate carrier, gamma-glutamyl hydrolase, and methylenetetrahydrofolate reductase (MTHF) were investigated in peripheral WBCs of consenting patients.
Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer.
Lenz et al., Los Angeles, United States. In J Clin Oncol, 2007
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate levels, which affects DNA synthesis and methylation.
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