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Methylenetetrahydrofolate dehydrogenase

Methylenetetrahydrofolate Dehydrogenase
a trifunctional enzyme combining a 10-formyl-H4folate synthetase, a 5,10-methenyl-H4folate cyclohydrolase, and a 5,10-methylene-H4folate dehydrogenase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, methylenetetrahydrofolate reductase, CAN, HAD, methionine synthase
Papers on Methylenetetrahydrofolate Dehydrogenase
Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status.
New
Murphy et al., Reus, Spain. In J Nutr, Jan 2016
METHODS: The associations between the methylenetetrahydrofolate reductase (MTHFR) 677C > T, methionine transferase reductase (MTRR) 66A > G, MTRR 524C > T, 5,10-methylenetetrahydrofolate dehydrogenase-5,10-methylenetetrahydrofolate cyclohydrolase-10-formyltetrahydrofolate synthetase (MTHFD1) 1958G > A, MTHFD1 -105C > T, dihydrofolate reductase (DHFR) 19-bp insertion/deletion, and solute carrier family 19A, member 1 (SLC19A1) 80G > A polymorphisms and fasting plasma folate (PF), red cell folate (RCF), and plasma total homocysteine (tHcy) were tested by ANCOVA and Cox regression analysis in 781 Spanish adults.
Physiological role of methylenetetrahydrofolate dehydrogenase (FolD), methenyl tetrahydrofolate cyclohydrolase (FchA) and formyl tetrahydrofolate synthetase (Fhs) from Clostridium perfringens in a heterologous model of Escherichia coli.
New
Varshney et al., In Microbiology, Dec 2015
UNASSIGNED: Organisms possess bifunctional FolD (5, 10-methylenetetrahydrofolate dehydrogenase/5, 10-methenyltetrahydrofolate cyclohydrolase) to generate NADPH and 10-formyltetrahdrofolate (10-CHO-THF) required in various metabolic steps.
Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring.
New
Kim et al., Seoul, South Korea. In Mol Cell Proteomics, Nov 2015
We determined that betaine-homocysteine S-methyltransferase 1, methylenetetrahydrofolate dehydrogenase 1, and ATP synthase subunit beta mitochondrial (ATP5B) expression levels were significantly reduced in the livers of rat offspring exposed to maternal food restriction during gestation compared with in the offspring of rats fed a normal diet (p < 0.05).
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
New
Costi et al., Milano, Italy. In J Med Chem, Nov 2015
The bifunctional enzyme N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclo hydrolase (FolD) is essential for growth in Trypanosomatidae.
Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.
New
Ulrich et al., New Brunswick, United States. In Cancer, Nov 2015
RESULTS: Statistically significant associations were observed between CRC risk and functionally defined candidate SNPs of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1; K134R), 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR; P450R), and PR domain containing 2 with ZNF domain (PRDM2; S450N) and a literature candidate SNP of thymidylate synthase (TYMS; g.676789A>T; nominal P < .05).
Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species.
New
Park et al., Seoul, South Korea. In Biochem Biophys Res Commun, Nov 2015
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase (NMDMC) is a bifunctional enzyme involved in folate-dependent metabolism and highly expressed in rapidly proliferating cells.
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells.
New
MacFarlane et al., Ottawa, Canada. In Br J Nutr, Oct 2015
Folate is an essential B vitamin required for de novo purine and thymidylate synthesis, and for the remethylation of homocysteine to form methionine. Folate deficiency has been associated with placenta-related pregnancy complications, as have SNP in genes of the folate-dependent enzymes, methionine synthase (MTR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1).
Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.
New
Jyothy et al., Hyderābād, India. In Dev Med Child Neurol, Oct 2015
AIM: This study aimed to evaluate the role of methylenetetrahydrofolate dehydrogenase (MTHFD1) G1958A variant (rs2236225) as a 'maternal, paternal, or embryonic' genetic risk factor for neural tube defect (NTD) susceptibility.
Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment.
Review
New
Baumgartner et al., Zürich, Switzerland. In J Inherit Metab Dis, Sep 2015
In the folate cycle MTHFD1, encoded by MTHFD1, is a trifunctional enzyme containing 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase activity.
Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.
Yang et al., Beijing, China. In Med Sci Monit, 2014
BACKGROUND: The polymorphism of methylenetetrahydrofolate dehydrogenase (MTHFD1) has been reported as a risk factor for neural tube defects (NTDs).
Quantitative flux analysis reveals folate-dependent NADPH production.
Impact
Rabinowitz et al., Princeton, United States. In Nature, 2014
As folate metabolism has not previously been considered an NADPH producer, confirmation of its functional significance was undertaken through knockdown of methylenetetrahydrofolate dehydrogenase (MTHFD) genes.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Review
Rosenblatt et al., Montréal, Canada. In J Inherit Metab Dis, 2012
Deficiency in the trifunctional enzyme containing methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase and formyltetrahydrofolate synthetase activities, has been identified in a single patient with megaloblastic anemia, atypical hemolytic uremic syndrome and severe combined immune deficiency.
Hippocampal levels of gamma-enolase, C-1-tetrahydrofolate synthase and serotransferrin fluctuate over the estrous cycle in the rat.
GeneRIF
Lubec et al., Vienna, Austria. In Neuroscience, 2008
C-1-tetrahydrofolate synthase levels were elevated in proestrous as compared with estrous
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases.
Review
Mackenzie et al., Montréal, Canada. In Vitam Horm, 2007
The products of these nuclear genes were derived from trifunctional precursor proteins, expressing methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetase activities.
Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development.
GeneRIF
Appling et al., Austin, United States. In Gene, 2003
Gene encodes the cytoplasmic isozyme of C1-tetrahydrofolate (THF) synthase, a trifunctional enzyme containing formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase activities (EC Numbers: 1.5.1.5, 3.5.4.9, 6.3.4.3).
Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism.
Review
Szpecht-Potocka et al., Warsaw, Poland. In J Appl Genet, 2001
Genes encoding methylenetetrahydrofolate reductase (MTHFR) or methylenetetrahydrofolate dehydrogenase (MTHFD) belong to the first group.
Folic acid metabolism and its disruption by pharmacologic agents.
Review
Vitols et al., Los Angeles, United States. In Nci Monogr, 1986
The following enzymes are particularly attractive as targets for future exploitation in chemotherapy: 1) the two transformylases involved in purine nucleotide synthesis, 2) serine hydroxymethyltransferase, 3) methionine synthetase, and 4) methylenetetrahydrofolate dehydrogenase.
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