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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

5-methyltetrahydrofolate-homocysteine methyltransferase

methionine synthase, MTR
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: methylenetetrahydrofolate reductase, SRA, ACID, CAN, HAD
Papers using methionine synthase antibodies
An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.
Supplier
Culhane Aedín C., In PLoS ONE, 2010
... The MTR-3 line (MCF-7 Tamoxifen-Resistant-3) was derived from the parental MCF-7 cells by continuously culturing the cells in the presence of 1 µM Tam (Sigma Aldrich) in phenol red-free DMEM ...
Papers on methionine synthase
An intact putative mouse telomerase essential N-terminal (TEN) domain is necessary for proper telomere maintenance.
New
Autexier et al., Montréal, Canada. In Biol Cell, Feb 2016
The Insi1 variant exhibited reduced DNA substrate binding in vitro and both variants exhibited a reduction in binding the telomerase RNA, mTR, when expressed in mTERT(-/-) ES cells.
Exploring sulfur assimilation of Aspergillus fumigatus reveals biosynthesis of sulfur-containing amino acids as a virulence determinant.
New
Krappmann et al., Erlangen, Germany. In Infect Immun, Feb 2016
Interestingly, we demonstrate that methionine synthase is essential for A. fumigatus virulence, defining the biosynthetic route of this proteinogenic amino acid as a potential antifungal target.
Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer.
New
Kutala et al., Thanjāvūr, India. In Gene, Feb 2016
Multifactor dimensionality reduction analysis showed the following interactions in responders to folate: RFC1 G80A× MTHFR C677T (primary), COMT H108L×CYP1A1 m2 (secondary), MTR A2756G (tertiary).
Amide Proton Transfer (APT) MR imaging and Magnetization Transfer (MT) MR imaging of pediatric brain development.
New
Peng et al., Beijing, China. In Eur Radiol, Feb 2016
The APT-weighted (APTW) and MT ratio (MTR) signals were quantitatively analyzed in multiple brain areas.
Crystal Structures and Coordination Behavior of Aqua- and Cyano-Co(III) Tetradehydrocorrins in the Heme Pocket of Myoglobin.
New
Hayashi et al., Suita, Japan. In Inorg Chem, Feb 2016
Taken together, the cyano-Co(III) tetradehydrocorrin in myoglobin is appropriate for investigation as a structural analogue of methylcobalamin, a key intermediate in methionine synthase reaction.
Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression.
Review
New
Singh et al., Patiāla, India. In Fundam Clin Pharmacol, Dec 2015
Impaired metabolism due to genetic alteration in metabolic enzymes (methionine synthase, methyltetrahydrofolate reductase (MTHFR), cystathionine β-synthase (CβS), and cystathionine-γ-lyase (CγL) or deficiency in cofactors (vitamin B6 , B12 , folate) may lead to acquired metabolic anomaly known as hyperhomocysteinemia. Hcy excess decreases the S-adenosylmethionine (SAM)-dependent synthesis of catecholamines, viz.
Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency.
Review
New
Nexo et al., Århus, Denmark. In Mol Nutr Food Res, Jul 2015
Methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl) are coenzymes for methionine synthase and methylmalonyl-CoA mutase, respectively.
Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice.
New
Impact
Pellegrini et al., Los Angeles, United States. In Cell Metab, Jul 2015
Methylation levels were regulated by genetics largely in cis, but we also found evidence of trans regulation, and we demonstrate that genetic variation in the methionine synthase reductase gene Mtrr affects methylation of hundreds of CpGs throughout the genome.
Redox regulation by reversible protein S-thiolation in bacteria.
Review
Antelmann et al., Greifswald, Germany. In Front Microbiol, 2014
In Bacillus subtilis, protein S-bacillithiolation controls the activities of the redox-sensing OhrR repressor and the methionine synthase MetE in vivo.
Associations of the A66G Methionine Synthase Reductase Polymorphism in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Review
Singh et al., Philippines. In Biomark Cancer, 2014
Inconsistency in the reported associations between the A66G polymorphism in the methionine synthase reductase (MTRR) gene and colorectal cancer (CRC) prompted a meta-analysis, so that we could obtain a more precise estimate.
Amaranthaceae pollens: review of an emerging allergy in the mediterranean area.
Review
Rodríguez et al., In J Investig Allergol Clin Immunol, 2013
To date, 9Amaranthaceae pollen allergens from Chenopodium album, Salsola kali, and Amaranthus retroflexus have been described and are listed in the International Union of Immunological Societies allergen nomenclature database.The major allergens ofAmaranthaceae pollen belong to the pectin methylesterase, Ole e 1-like, and profilin panallergen families, whereas the minor allergens belong to the cobalamin- independent methionine synthase and polcalcin panallergen families.
What's the Mtrr with your grandparents?
Impact
Shi et al., Boston, United States. In Cell Metab, 2013
(2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descendants for up to four generations.
Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development.
Impact
Watson et al., Cambridge, United Kingdom. In Cell, 2013
The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle.
Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia.
Impact
Pui et al., Memphis, United States. In J Clin Oncol, 2013
Children with the A2756G polymorphism in methionine synthase (MS) were more likely to demonstrate deficits in attentiveness (P = .03)
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Impact
Gems et al., London, United Kingdom. In Cell, 2013
Alterations in metformin-induced longevity by mutation of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-induced methionine restriction in the host, consistent with action of this drug as a dietary restriction mimetic.
Folate gene polymorphisms MTR A2756G, MTRR A66G, and BHMT G742A and risk for coronary artery disease: a meta-analysis.
GeneRIF
Lele et al., Mumbai, India. In Genet Test Mol Biomarkers, 2012
We found weak evidence of a recessive effect of the G allele in MTR A2756G (odds ratio, 1.61 [95% confidence interval, 0.98-2.66]; p=0.06)and risk for coronaryh artery diseae.
Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia.
GeneRIF
Filipenko et al., Novosibirsk, Russia. In Bull Exp Biol Med, 2012
No statistically significant association with prostate cancer was detected for the polymorphic locus A2756G of methionine synthase gene.
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India.
GeneRIF
Kaur et al., Chandīgarh, India. In Exp Oncol, 2011
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India
Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.
GeneRIF
Iqbal et al., Karāchi, Pakistan. In Plos One, 2011
The average changes in plasma homocysteine levels for methionine synthase 2756AG and GG variants were negative [beta(SE beta), -0.56(0.58) and -0.83(0.99) micromol/L, respectively].
The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.
GeneRIF
Yu et al., Chongqing, China. In Int J Biol Sci, 2011
No significant association was found between MTR A2756G polymorphisms and the risk of CRC.
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