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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate receptor, metabotropic 5

metabotropic glutamate receptor, mGluR5, GluR5, metabotropic glutamate receptor 5
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, mGluR, mGluR1, V1a, ACID
Papers using metabotropic glutamate receptor antibodies
Intracortical excitation of spiny neurons in layer 4 of cat striate cortex in vitro
Supplier
Sherman S. Murray et al., In Frontiers in Systems Neuroscience, 1998
... To block the group 1 mGluRs, LY367385 (20 μM) for mGluR1 and MPEP (30 μM) for mGluR5 (TOCRIS, Ellisville, MO, USA) were ...
Papers on metabotropic glutamate receptor
Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.
New
Logothetis et al., Richmond, United States. In Pflugers Arch, Feb 2016
UNASSIGNED: We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011-1023, 2011) results in inverse cross-signaling, where for either receptor, strong agonists suppress and inverse agonists potentiate the signaling of the partner receptor.
The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats.
New
Gorji et al., Tehrān, Iran. In Mol Neurobiol, Feb 2016
UNASSIGNED: Modulatory function of metabotropic glutamate type 1 (mGlu1) receptors plays a crucial role in the pathophysiology of some neurological disorders, including schizophrenia and epilepsy.
Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.
Review
New
Tipre et al., Stony Brook, United States. In Eur J Nucl Med Mol Imaging, Feb 2016
UNASSIGNED: This review summarizes the contributions by various teams of scientists in assessing the metabotropic glutamate receptor 5 (mGluR5) as a biomarker in neuropsychiatric disorders and diseases.
New targets for rapid antidepressant action.
Review
New
Zarate et al., Bethesda, United States. In Prog Neurobiol, Jan 2016
This article reviews the clinical evidence supporting the use of novel glutamate receptor modulators with direct affinity for cognate receptors: (1) non-competitive NMDA receptor antagonists (ketamine, memantine, dextromethorphan, AZD6765); (2) subunit (GluN2B)-specific NMDA receptor antagonists (CP-101,606/traxoprodil, MK-0657); (3) NMDA receptor glycine-site partial agonists (GLYX-13); and (4) metabotropic glutamate receptor (mGluR) modulators (AZD2066, RO4917523/basimglurant).
Signal integration by Ca(2+) regulates intestinal stem-cell activity.
New
Impact
Jasper et al., Novato, United States. In Nature, Jan 2016
The metabotropic glutamate receptor (mGluR) is required in ISCs for this response, and for an associated modulation of cytosolic Ca(2+) oscillations that results in sustained high cytosolic Ca(2+) concentrations.
mGlu5, Dopamine D2 and Adenosine A2A Receptors in L-DOPA-Induced Dyskinesias.
Review
New
Di Paolo et al., Québec, Canada. In Curr Neuropharmacol, Jan 2016
An approach to manage LID is to add to L-DOPA specific agents to reduce dyskinesias such as metabotropic glutamate receptor (mGlu receptor) drugs.
The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder.
New
Hakonarson et al., Seattle, United States. In Sci Rep, Dec 2015
While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved in the pathophysiology of Autism Spectrum Disorder (ASD), Fragile X Syndrome and Tuberous Sclerosis, the role of other mGluRs and their associated signaling network genes in syndromic ASD is unknown.
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways.
New
Impact
Araque et al., Madrid, Spain. In Science, Sep 2015
Likewise, astrocyte subpopulations selectively regulated homotypic synapses through metabotropic glutamate receptor activation.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.
The influence of glutamatergic receptor antagonists on biochemical and ultrastructural changes in myelin membranes of rats subjected to experimental autoimmune encephalomyelitis.
Sulkowski et al., Warsaw, Poland. In Folia Neuropathol, 2014
The aim of the study was to test the effects of the glutamatergic receptor antagonists amantadine and memantine (antagonists of NMDA receptors), LY 367384 (an antagonist of mGluR1), and MPEP (an mGluR5 antagonist) on the development of neurological symptoms in immunized animals, morphological changes in cerebral myelin, and expression of mRNA of the principal myelin proteins PLP, MBP, MOG, MAG, and CNPase.
Effects of mGluR5 positive and negative allosteric modulators on brain damage evoked by hypoxia-ischemia in neonatal rats.
Łazarewicz et al., Warsaw, Poland. In Folia Neuropathol, 2014
In the present study, we examined the effects of negative and positive allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), fenobam and ADX47273, respectively, on brain damage induced by hypoxia-ischemia (H-I) in 7-day-old rats.
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Impact
Marshall et al., Welwyn Garden City, United Kingdom. In Nature, 2014
Metabotropic glutamate receptor 5 is of considerable interest as a drug target in the treatment of fragile X syndrome, autism, depression, anxiety, addiction and movement disorders.
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.
Impact
Turecki et al., Montréal, Canada. In Nat Med, 2014
Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 (GRM4) and predicts antidepressant response at baseline.
Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
Impact
Kano et al., Tokyo, Japan. In Science, 2014
The effect of Sema7A involves signaling by metabotropic glutamate receptor 1, a canonical pathway for climbing fiber synapse elimination.
Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum.
GeneRIF
Bordey et al., New Haven, United States. In Neuroscience, 2012
findings identify a unique role for glutamate acting at mGlu(5)Rs as a functional switch regulating the survival granule cell precursors in the external germinal layer
mGluR5 knockout mice display increased dendritic spine densities.
GeneRIF
Brumberg et al., New York City, United States. In Neurosci Lett, 2012
Highlighted the role that the mGluR5 receptor plays in determining morphological properties as well as densities of dendritic spines, and hence its role in potentially influencing the synaptic functioning in the brain.
Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress.
GeneRIF
Kim et al., Seoul, South Korea. In Neurosci Lett, 2012
The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
GeneRIF
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that grik1 gene expression in mouse dorsal raphe nucleus
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.
GeneRIF
Crawley et al., Bethesda, United States. In Sci Transl Med, 2012
mGluR5 receptor antagonist reduces repetitive behaviors and rescues social deficits in mouse models of autism.
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