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MET2 Met2p

MET2, Dnmt2
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: DNA methyltransferase, ACID, CAN, HAD, V1a
Papers on MET2
Physcomitrella patens DNA Methyltransferase 2 is Required for Recovery from Salt and Osmotic Stress.
Kapoor et al., New Delhi, India. In Febs J, Jan 2016
UNASSIGNED: DNA methyltransferase 2 (DNMT2) unlike other members of the cytosine DNA methyltransferase gene family has dual substrate specificity and it methylates cytosines in both the DNA and transfer RNA (tRNA).
Dynamic expression of DNA methyltransferases (DNMTs) in oocytes and early embryos.
Ozturk et al., Antalya, Turkey. In Biochimie, Sep 2015
Five DNMT enzymes have been identified in mammals including DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L.
Egg-specific expression of protein with DNA methyltransferase activity in the biocarcinogenic liver fluke Clonorchis sinensis.
Bae et al., Inch'ŏn, South Korea. In Parasitology, Aug 2015
This ambiguity is reinforced by discoveries of DNA methyltransferase 2 (DNMT2)-only organisms and the substrate specificity of DNMT2 preferential to RNA molecules.
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
MacFarlane et al., Ottawa, Canada. In Am J Clin Nutr, Jun 2015
Other SNPs included those in the DNMT2, DPEP1, FUT2, NOX4, and PON1 genes.
Age-related microstructural differences quantified using myelin water imaging and advanced diffusion MRI.
Emsell et al., Leuven, Belgium. In Neurobiol Aging, Jun 2015
Combining multiexponential T2 relaxation (MET2) and multishell diffusion MRI (dMRI) techniques may elucidate such processes.
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Jeltsch et al., Stuttgart, Germany. In Biochimie, May 2015
The DNMT2 protein methylates C38 of tRNA-Asp and it has a role in cellular physiology and stress response and its expression levels are altered in cancer tissues.
PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation.
Pang et al., Wuhan, China. In Drug Metab Dispos, Apr 2015
After correction for the adsorption of 10%-25% dose verapamil and norverapamil onto Tygon tubing and binding to albumin and red blood cell, fitting of verapamil and formed and preformed norverapamil data with ADAPT5 revealed nonlinearity for protein binding, N-demethylation (V(max,met1)(VER --> NOR) = 96.6 ± 33.4 nmol/min; K(m,met1)(VER --> NOR) = 10.4 ± 4.1 μM), formation of other metabolites (V(max,met2(VER -->others) 288 ± 51 nmol/min; K(m.met2)(VER -->others )= 14.1 ± 4.9 μM), as well as biliary excretion (V(max,sec)(VER)= 0.911 ± 0.505 nmol/min; K(m,sec)(VER) = 4.75 ± 2.29 μM).
Identification of new Saccharomyces cerevisiae variants of the MET2 and SKP2 genes controlling the sulfur assimilation pathway and the production of undesirable sulfur compounds during alcoholic fermentation.
Blondin et al., Blagnac, France. In Microb Cell Fact, 2014
A QTL mapping strategy then enabled us to identify MET2 and SKP2 as the genes responsible for these phenotypic differences between strains and we identified new variants of these genes in the low-sulfite producer strain.
Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases.
Zhang et al., Shiyan, China. In Int J Clin Exp Med, 2014
DNA methylation is governed by the interaction of DNA methyltransferases (DNMT).
DNA methyltransferases: a novel target for prevention and therapy.
Anant et al., Kansas City, United States. In Front Oncol, 2013
DNMT2 or TRDMT1, the smallest mammalian DNMT is believed to participate in the recognition of DNA damage, DNA recombination, and mutation repair.
Identification of direct targets and modified bases of RNA cytosine methyltransferases.
Cairns et al., Salt Lake City, United States. In Nat Biotechnol, 2013
When applied in a human cell line to the RNA methyltransferases DNMT2 and NSUN2, Aza-IP enabled >200-fold enrichment of tRNAs that are known targets of the enzymes.
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
Lyko et al., Heidelberg, Germany. In Nat Struct Mol Biol, 2012
Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis.
[DNA methylation in Drosophila, a review of recent studies].
Zhang et al., Xi'an, China. In Yi Chuan, 2011
dDNMT2 shows significant homology to the mammalian methyltransferases DNMT2 family, and dMBD2/3 encodes a protein with distinct homology to mammalian methyl-binding proteins MBD2 and MBD3.
The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.
Khosla et al., Hyderābād, India. In Epigenetics, 2011
the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection.
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
Lyko et al., Heidelberg, Germany. In Genes Dev, 2010
in addition to tRNA(Asp-GTC), tRNA(Val-AAC) and tRNA(Gly-GCC) are also methylated by Dnmt2
DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia.
Bökesoy et al., Ankara, Turkey. In Mol Biol Rep, 2010
The expression of DNMT1, DNMT2, DNMT3A and DNMT3B in pediatric acute lymphoblastic leukemia patients, was investigated.
Hepatitis B virus replication induces methylation of both host and viral DNA.
Torbenson et al., Baltimore, United States. In J Virol, 2010
Hepatitis B virus-induced overexpression of DNMTs leads to viral DNA methylation and decreased viral gene expression and also leads to methylation of host CpG islands.
[Molecular mechanisms of parthenolide's action: Old drug with a new face].
Czyz et al., In Postepy Hig Med Dosw (online), 2009
At the epigenetic level, parthenolide reduces HDAC1 level and, by inhibiting DNMT2 activity, induces global hypomethylation of DNA, which can restore the expressions of some suppressor genes.
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2.
Reuter et al., Halle, Germany. In Nat Genet, 2009
ytosine-5 methyltransferase DNMT2 controls retrotransposon silencing in Drosophila somatic cells.
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
Bestor et al., New York City, United States. In Science, 2006
genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop
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