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Neurofibromin 2

merlin, NF2, Neurofibromin 2, ACN
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, NF1, ACID
Papers using merlin antibodies
First partial proteome of the poultry pathogen Mycoplasma synoviae.
Rouet Philippe, In PLoS ONE, 2009
... Tris, acetone, bromophenol blue, Coomassie® Brilliant Blue G-250, methanol, acetic acid, ACN, and TFA were purchased from Merck KGaA (Darmstadt, Germany) ...
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation
Köster Hubert et al., In Molecular & Cellular Proteomics : MCP, 2008
... MS grade ACN, methanol, ethanol, and water were purchased from Merck; trypsin was purchased from ...
Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent-monacolin K and antiinflammation agent-monascin
Ariff Arbakariya B. et al., In Journal of Biomedicine and Biotechnology, 2005
... Other chemicals, including methanol and acetonitrile (ACN), ethyl acetate, isopropanol, butanol (HPLC grade), and ethanol (analytical grade) were obtained from Merck (Germany) ...
TPP project
Zou Hanfa et al., In BMC Bioinformatics, 2005
... Acetonitrile (ACN, HPLC grade) was from Merck (Darmstadt, Germany) ...
A catalogue of human saliva proteins identified by free flow electrophoresis-based peptide separation and tandem mass spectrometry
Roelofsen Han et al., In Biomarker Insights, 2004
... Acetonitrile (ACN) and acetone were obtained from Biosolve (Valkenswaard, The Netherlands), leupeptin from Roche (Mannheim, Germany) and ammonium acetate and 2-propanol from Merck (Darmstadt, Germany) ...
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Papers on merlin
Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis.
Chopra et al., Galveston, United States. In Proc Natl Acad Sci U S A, Feb 2016
NF2, which harbors exotoxin A (exoA) gene, was highly virulent when injected alone, but its virulence was attenuated in the presence of NF1 (exoA-minus).
Solvation of the morpholinium cation in acetonitrile. Effect of an anion.
Andreeva et al., São Paulo, Brazil. In J Mol Model, Jan 2016
We investigate local structures of protic and apropic morpholinium cations in acetonitrile (ACN) using semi-empirical molecular dynamics (MD) simulations.
Tumors displaying hybrid schwannoma and neurofibroma features in patients with neurofibromatosis type 2.
Germanwala et al., In Clin Neuropathol, Jan 2016
We report the clinicopathological features of these hybrid nerve sheath tumors in patients with neurofibromatosis type 2 (NF2).
Diagnosis, Management, and New Therapeutic Options in Childhood Neurofibromatosis Type 2 and Related Forms.
Evans et al., Catania, Italy. In Semin Pediatr Neurol, Dec 2015
which encodes for a protein called merlin or schwannomin, most similar to the exrin-readixin-moesin proteins; mosaic or segmental NF2 is because of mosaic phenomena for the NF2 gene, whereas SWNTS is caused by germline and possibly mosaic mutations either in the SMARCB1 gene (SWNTS1; MIM # 162091) or the LZTR1 gene (SWNTS2; MIM # 615670), both falling within the 22q region.
Renal carcinoma associated with a novel succinate dehydrogenase A mutation: a case report and review of literature of a rare subtype of renal carcinoma.
Netto et al., İstanbul, Turkey. In Hum Pathol, Dec 2015
Hybrid capture-based comprehensive genomic profiling identified 3 genomic alterations in tumor tissue: (i) a novel single-nucleotide splice site deletion in SDHA gene, (ii) single-nucleotide deletion in NF2 gene, and (iii) EGFR gene amplification of 19 copies.
Neuroblastoma-like schwannoma in a case of schwannomatosis: Report of a rare case.
Ramteerthakar et al., India. In Int J Health Sci (qassim), Oct 2015
Schwannomatosis is a term used to describe patients with multiple nonvestibular schwannomas with no other stigmata of neurofibromatosis type-2 (NF2).
Tumor Biology of Vestibular Schwannoma: A Review of Experimental Data on the Determinants of Tumor Genesis and Growth Characteristics.
Hogendoorn et al., Leiden, Netherlands. In Otol Neurotol, Aug 2015
BACKGROUND: Vestibular schwannomas are benign tumors originating from the eighth cranial nerve and arise due to inactivation of the NF2 gene and its product merlin.
Pleural neoplastic pathology.
Froudarakis et al., Ioánnina, Greece. In Respir Med, Aug 2015
Various genetic alterations like changes in INK4 locus, NF2, BAP1 but also epigenetic changes are present in MPM.
Neurofibromatosis type 2.
Slattery, Los Angeles, United States. In Otolaryngol Clin North Am, Jun 2015
Neurofibromatosis type 2 (NF2) is a rare syndrome characterized by bilateral vestibular schwannomas, multiple meningiomas, cranial nerve tumors, spinal tumors, and eye abnormalities.
[Treatment research progress on the treatment of neurofibromatosis type 2-associated vestibular schwannoma].
Jiang et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, May 2015
Neurofibromatosis type 2 (NF2) is a dominantly inherited genetic condition.
Merlin's wizardry guides cohesive migration.
Morrison et al., Jena, Germany. In Nat Cell Biol, Mar 2015
The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin-Rich1 complex and the Rac1 small GTPase.
A molecular mechanotransduction pathway regulates collective migration of epithelial cells.
Spatz et al., Stuttgart, Germany. In Nat Cell Biol, Mar 2015
Here we show that a tumour suppressor protein, merlin, coordinates collective migration of tens of cells, by acting as a mechanochemical transducer.
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Seshagiri et al., San Francisco, United States. In Nat Genet, 2015
We identified ten significantly mutated genes in pRCC, including MET, NF2, SLC5A3, PNKD and CPQ.
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
Giancotti et al., New York City, United States. In Cancer Cell, 2014
It is currently unclear whether Merlin/NF2 suppresses tumorigenesis by activating upstream components of the Hippo pathway at the plasma membrane or by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas.
Messiaen et al., Birmingham, United States. In Nat Genet, 2014
We sequenced highly conserved regions along 22q from eight individuals with schwannomatosis whose schwannomas involved somatic loss of one copy of 22q, encompassing SMARCB1 and NF2, with a different somatic mutation of the other NF2 allele in every schwannoma but no mutation of the remaining SMARCB1 allele in blood and tumor samples.
Clinicopathologic and molecular analysis of a choroidal pigmented schwannoma in the context of a PTEN hamartoma tumor syndrome.
Rivolta et al., Lausanne, Switzerland. In Ophthalmology, 2012
We report the first description of a pigmented choroidal schwannoma in PTEN hamartoma tumor syndrome (PHTS). This rare tumor showed a unique combination of reduction of PTEN and absence of NF2 expression.
Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
Jain et al., Boston, United States. In Neoplasia, 2012
in addition to the tumor-suppressing activity of merlin, it also functions to maintain physiological angiogenesis in the nervous system by regulating antiangiogenic factors such as SEMA3F
Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma.
Johnson et al., Boston, United States. In Neoplasia, 2012
alternative splicing and frequent codeletion of CHEK2 and NF2 contribute to the genomic instability and associated development of aggressive biologic behavior in meningiomas.
Lack of neurofibromatosis type 2 gene promoter methylation in sporadic vestibular schwannomas.
Brieger et al., Mainz, Germany. In Orl J Otorhinolaryngol Relat Spec, 2011
NF2 gene inactivation by promoter hypermethylation is a rare or very uncommon mechanism of NF2 gene inactivation in sporadic VS.
Genetic and epigenetic alterations of the NF2 gene in sporadic vestibular schwannomas.
Lee et al., Puch'ŏn, South Korea. In Plos One, 2011
The molecular genetic changes in sporadic VS identified here included mutations and allelic loss, but no aberrant hypermethylation of the NF2 gene was detected
More papers using merlin antibodies
Determination of perfluorocarboxilic acids in aqueous matrices by ion-pairing solid-phase microextraction-in-port derivatization-gas chromatography-negative ion chemical ionization mass spectrometry
Trojanowicz Marek et al., In Mikrochimica Acta, 2003
... Methanol and acetonitrile (ACN), both of chromatographic purity, were obtained from Merck (Darmstadt, Germany, ...
Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver.
Gaetani Silvana, In PLoS ONE, 2000
... Methanol (MeOH), acetone and acetonitrile (ACN) were obtained from Merck (Darmstadt, Germany) ...
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
Giancotti Filippo G. et al., In The Journal of Cell Biology, 1997
... purchased: anti-Rac1 (Upstate Biotechnology); anti-RhoGDI, anti–cyclin D1 (A-12), anti-p27 (C-19), anti-Erk2 (C-14), anti-PAK (N-20), and anti-Merlin (A-19, C-18; Santa Cruz Biotechnology, Inc.); anti–β-actin (Sigma-Aldrich); anti–phospho-ERK ...
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
Tang Dean G., In PLoS ONE, 1994
... Rabbit anti-human phospho-Merlin (Ser518) antibodyCell Signaling Technology ...
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