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Serpin peptidase inhibitor, clade I

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, P10, CAN, Plasminogen, vascular endothelial growth factor
Papers on MEPI
Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis.
Martínez et al., Murcia, Spain. In Hum Reprod, Oct 2015
STUDY FUNDING/COMPETING INTERESTS: This work was supported by research grants by ISCIII and FEDER (PI11/00091, PI11/00566, PI14/01309, PI14/00253 and FI12/00012), RIC (RD12/0042/0029 and RD12/0042/0050), IIS La Fe 2011-211, Prometeo 2011/027 and Contrato Sara Borrell CD13/0005.
Expression of candidate genes for residual feed intake in Angus cattle.
Chen et al., Armidale, Australia. In Anim Genet, 2014
Gene expression of eight candidate genes (AHSG, GHR, GSTM1, INHBA, PCDH19, S100A10, SERPINI2 and SOD3), previously identified as differentially expressed between divergent lines of high- and low-RFI animals, was measured in an unselected population of 60 steers from the Angus Society Elite Progeny Test Program using quantitative real-time PCR.
Physician tracking in sub-Saharan Africa: current initiatives and opportunities.
Rugarabamu et al., Washington, D.C., United States. In Hum Resour Health, 2013
Primary data on physician tracking activities was collected as part of the Medical Education Partnership Initiative (MEPI) - through two rounds over two years of annual surveys to 13 medical schools in 12 sub-Saharan countries.
Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa.
Hassan et al., Wayne, United States. In J Perinat Med, 2013
RESULTS: i) 43 and 28 genes were differentially expressed in early- and late-onset PE compared to the control group, respectively; ii) qRT-PCR confirmed the microarray results for early and late-onset PE in 77% (33/43) and 71% (20/28) of genes, respectively; iii) 20 genes that are involved in coagulation (SERPINI2), immune regulation (VSIG4, CD24), developmental process (H19) and inflammation (S100A10) were differentially expressed in early-onset PE alone.
Common polymorphisms in the SERPINI2 gene are associated with refractive error in the 1958 British Birth Cohort.
Rahi et al., London, United Kingdom. In Invest Ophthalmol Vis Sci, 2012
The findings indicate that SERPINI2 is a promising candidate for further investigations of the genetic susceptibility to myopia.
Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.
Pscherer et al., Heidelberg, Germany. In Leukemia, 2009
CCDC50 (coiled coil domain containing protein 50), SERPINI2 and SMARCC2 mediated a reduction of cell viability in primary CLL cells as well as in cell lines.
Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer.
Groen et al., Groningen, Netherlands. In J Pathol, 2009
The down-regulated genes included several tumour suppressor genes, such as C9orf9, INHBB, LRIG1, SCGB3A1, SERPINI2, STEAP3 and ZMYND10.
Altered expression of angiogenesis-related placental genes in pre-eclampsia associated with intrauterine growth restriction.
Ryynanen et al., Oulu, Finland. In Gynecol Endocrinol, 2007
RESULTS: Gene expression profiling revealed that the expression level of nine genes--ECGF1, JAG1, Palladin, COL18A1, TNFSF12, VEGF, ANPEP, PDGFRA and SERPIN12 - was downregulated whereas the level of four genes--EPAS1, FLT1, SIGLE10 and ANG4--was upregulated in the study group compared with the control group.
Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency.
Pavan et al., Bethesda, United States. In Plos Genet, 2005
The rescue of growth retardation, immunodeficiency, and mortality by either Serpini2 bacterial artificial chromosome transgenic expression or by pancreatic enzyme supplementation demonstrates these phenotypes as secondary to malnutrition.
Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26.
Wu et al., Taipei, Taiwan. In Genes Chromosomes Cancer, 2000
We have studied a novel serpin gene cluster at 3q26 containing at least two recently identified members: the pancreas-specific protease inhibitor, pancpin (PI14), and the brain-associated protease inhibitor, neuroserpin (PI12).
Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells.
Shi et al., Long Beach, United States. In Proc Natl Acad Sci U S A, 1999
In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and thus was named myoepithelium-derived serine proteinase inhibitor (MEPI).
Effect of 3'-azido-3'-deoxythymidine (AZT) on organic ion transport in rat renal brush border membrane vesicles.
Sokol et al., Indianapolis, United States. In J Pharmacol Exp Ther, 1992
AZT inhibited pH-driven [3H]N'-methylnicotinamide transport (pHi = 6.0, pH0 = 7.5), but not as effectively as mepiperphenidol (MEPI), a known organic cation transport blocker; the corresponding IC50 values for AZT and MEPI were 2500 and 25 microM, respectively.
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