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Mesenchyme homeobox 1

Meox1, Mox1
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PAX3, CAN, GAX, MyoD, Pax1
Papers on Meox1
Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome.
New
Baylor-Hopkins Center for Mendelian Genomics et al., Adana, Turkey. In Am J Med Genet A, Nov 2015
Mutated genes for both dominant (GDF6 and GDF3) and recessive (MEOX1) forms of Klippel-Feil syndrome have been shown to be involved in somite development via transcription regulation and signaling pathways.
A skeletal disorder in a dog resembling the Klippel-Feil Syndrome with Sprengel's Deformity in humans.
New
Caldin et al., Padova, Italy. In J Small Anim Pract, Mar 2015
Polymerase chain reaction (PCR) and direct sequencing of MEOX1, PAX1 and FGFR3 genes were performed in this dog to investigate a possible underlying genetic predisposition, but no mutations were detected in the coding regions of the three target genes evaluated.
Two girls with short stature, short neck, vertebral anomalies, Sprengel deformity and intellectual disability.
David et al., Nantes, France. In Eur J Med Genet, 2015
However, direct sequencing of GDF6, GDF3, PAX1, and MEOX1 failed to identify any mutation.
Ski diminishes TGF-β1-induced myofibroblast phenotype via up-regulating Meox2 expression.
Wang et al., Zhengzhou, China. In Exp Mol Pathol, 2014
Western blotting was used to detect the protein expression of α-SMA, E-cadherin, Meox1, Meox2, Zeb1 and Zeb2.
Small molecule-directed specification of sclerotome-like chondroprogenitors and induction of a somitic chondrogenesis program from embryonic stem cells.
Nakayama et al., Houston, United States. In Development, 2014
Mesodermal progeny generated using such small molecules were chondrogenic in vitro, and expressed trunk paraxial mesoderm markers such as Tcf15 and Meox1, and somite markers such as Uncx, but failed to express sclerotome markers such as Pax1.
The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.
Dixon et al., Winnipeg, Canada. In J Cell Sci, 2014
We show that expression of Meox1 and Meox2 mRNA and Meox2 protein is reduced during phenoconversion of fibroblasts to myofibroblasts.
Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly.
Alkuraya et al., Riyadh, Saudi Arabia. In Am J Hum Genet, 2013
locus that harbors a homozygous frameshift deletion in MEOX1; this deletion results in complete instability of the transcript.
Mutation in MEOX1 gene causes a recessive Klippel-Feil syndrome subtype.
Kars et al., Sivas, Turkey. In Bmc Genet, 2012
Exome sequencing identified the G > A p.Q84X mutation in the MEOX1 gene, which is segregated based on pedigree status.
Induction of Pax3 gene expression impedes cardiac differentiation.
Chen et al., Ottawa, Canada. In Sci Rep, 2012
Interestingly, the inhibitory effect of small molecules on cardiac differentiation depends on the function of Pax3, but not the mesoderm factor Meox1.
β-catenin is essential for efficient in vitro premyogenic mesoderm formation but can be partially compensated by retinoic acid signalling.
Skerjanc et al., Ottawa, Canada. In Plos One, 2012
While RA could upregulate premyogenic mesoderm expression, including Pax3/7 and Meox1, only Pax3/7 and Gli2 could be upregulated by RA in the presence of β-cat/EnR.
MYOD mediates skeletal myogenic differentiation of human amniotic fluid stem cells and regeneration of muscle injury.
Park et al., In Stem Cell Res Ther, 2012
Analysis of pre-myogenic factors showed that expression of PAX3, MEOX1 and EYA2 was significantly increased by MYOD.
Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.
GeneRIF
Wang et al., Baltimore, United States. In Plos One, 2011
The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers.
Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.
GeneRIF
Bobola et al., Manchester, United Kingdom. In Mol Cell Biol, 2011
Meox1 expression is downregulated in the second arch of Hoxa2 mouse mutant embryos.
Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
GeneRIF
Wigle et al., Winnipeg, Canada. In Plos One, 2010
MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner.
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.
GeneRIF
Arnheiter et al., Bethesda, United States. In Dev Biol, 2009
Data sugges that Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation.
Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1.
GeneRIF
Wilcox et al., Los Angeles, United States. In Am J Med Genet A, 2007
No mutations were identified in the PAX1 and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis
Systems developmental biology: the use of ontologies in annotating models and in identifying gene function within and across species.
Review
Bard, Edinburgh, United Kingdom. In Mamm Genome, 2007
Second, Boolean analysis of the G-E profiles of the mesenchyme-to-epithelium transitions that take place during mouse development suggest Lhx1, Foxc1, and Meox1 as candidate transcription factors for mediating this process.
Cell transformation by the superoxide-generating oxidase Mox1.
Impact
Lambeth et al., Atlanta, United States. In Nature, 1999
Here we describe the cloning of mox1, which encodes a homologue of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox.
Mox2 is a component of the genetic hierarchy controlling limb muscle development.
Impact
Pachnis et al., London, United Kingdom. In Nature, 1999
Mox1 and Mox2 are closely related homeobox genes that are expressed in overlapping patterns in the paraxial mesoderm and its derivatives.
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