Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations.
New York City, United States. In Cell Mol Neurobiol, Oct 2015
Recent evidence implicates vascular oxidative stress and activation of the non-selective cationic channel transient receptor potential melastatin (TRPM)-2 on endothelial cells in the mechanisms of Aβ-induced neurovascular dysfunction.
Magnesium in man: implications for health and disease.
Nijmegen, Netherlands. In Physiol Rev, 2015
Over the last decade, several hereditary forms of hypomagnesemia have been deciphered, including mutations in transient receptor potential melastatin type 6 (TRPM6), claudin 16, and cyclin M2 (CNNM2).
The Genetics of Deafness in Domestic Animals.
Baton Rouge, United States. In Front Vet Sci, 2014
Across species, the genes identified with deafness or white pigmentation patterns include MITF, PMEL, KIT, EDNRB, CDH23, TYR, and TRPM1 in dog, cat, horse, cow, pig, sheep, ferret, mink, camelid, and rabbit.
mGluR6 deletion renders the TRPM1 channel in retina inactive.
Guangzhou, China. In J Neurophysiol, 2012
The results suggested that the TRPM1 channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized.
The menthol receptor TRPM8 is the principal detector of environmental cold.
San Francisco, United States. In Nature, 2007
One such channel--TRP melastatin 8 (TRPM8) or cold and menthol receptor 1 (CMR1)--is activated by chemical cooling agents (such as menthol) or when ambient temperatures drop below approximately 26 degrees C, suggesting that it mediates the detection of cold thermal stimuli by primary afferent sensory neurons.