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Antigen p97

Melanotransferrin, MTf, melanoma-associated antigen p97
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Transferrin, p97, CAN, ACID, HAD
Papers on Melanotransferrin
Enhanced delivery of etoposide across the blood-brain barrier to restrain brain tumor growth using melanotransferrin antibody- and tamoxifen-conjugated solid lipid nanoparticles.
Wang et al., Zhengzhou, China. In J Drug Target, Feb 2016
UNASSIGNED: Melanotransferrin antibody (MA) and tamoxifen (TX) were conjugated on etoposide (ETP)-entrapped solid lipid nanoparticles (ETP-SLNs) to target the blood-brain barrier (BBB) and glioblastom multiforme (GBM).
Conjugation of Melanotransferrin Antibody on Solid Lipid Nanoparticles for Mediating Brain Cancer Malignancy.
Chao et al., Zhengzhou, China. In Biotechnol Prog, Jan 2016
UNASSIGNED: Solid lipid nanoparticles (SLNs) comprising complex internal lipids were conjugated with melanotransferrin antibody (MA) to carry anticancer etoposide across the blood-brain barrier (BBB) for managing glioblastoma multiforme (GBM).
Pattern of Melanotransferrin Expression in Human Colorectal Tissues: An Immunohistochemical Study on Potential Clinical Application.
Ziółkowski et al., Wrocław, Poland. In Anticancer Res, Dec 2015
We observed a significantly changed expression of 25% of all identified proteins between patient and matched adjacent normal mucosa, carcinoma and colorectal adenoma, including melanotransferrin.
Phylogenomic analysis of transferrin family from animals and plants.
Chen et al., Wuhan, China. In Comp Biochem Physiol Part D Genomics Proteomics, Dec 2015
Melanotransferrin and serotransferrin are widely distributed in vertebrates, while melanotransferrin-like and transferrin-like 1 are frequent in invertebrates.
Nuclear respiratory factor-2α and adenosine triphosphate synapses in rat primary cortical neuron cultures: The key role of adenosine monophosphate-activated protein kinase.
Wei et al., Beijing, China. In Mol Med Report, Oct 2015
NRF‑2α regulates mitochondrial transcription factors (mTF)A and B, and mitochondrial DNA by indirectly regulating the mitochondrial respiratory enzyme chain subunit.
Comparative proteomic analysis of drought tolerance in the two contrasting Tibetan wild genotypes and cultivated genotype.
Wu et al., Hangzhou, China. In Bmc Genomics, 2014
Among them, 6 protein spots were exclusively expressed or up-regulated under drought stress in XZ5 but not in XZ54, including melanoma-associated antigen p97, type I chlorophyll a/b-binding protein b, glutathione S-transferase 1, ribulosebisphosphate carboxylase large chain.
Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage.
Steinberg et al., Stanford, United States. In J Stroke Cerebrovasc Dis, 2012
Category B markers included apolipoprotein E (ApoE), F2-isoprostane (F2-IsoP), NOx, and the indicators for thrombin activity membrane-bound tissue factor (mTF) and thrombin-antithrombin III complex (TAT) for neurologic outcome prediction, as well as E-selectin, lactate, alpha-II spectrin breakdown products (SBDPs), asymmetric dimethyl-L-arginine (ADMA), and monocyte chemoattractant protein-1 (MCP-1) for vasospasm prognostication.
Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila.
Samakovlis et al., Stockholm, Sweden. In Nat Cell Biol, 2010
Melanotransferrin (MTf) is a phylogenetically conserved, iron-binding epithelial protein.
PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis.
Waxman et al., Boston, United States. In Mol Cancer, 2009
PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low.
Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.
Richardson et al., London, United Kingdom. In Int J Biochem Cell Biol, 2007
Biochemical and spectroscopic studies of MTF1 are reported.
Identification of distinct changes in gene expression after modulation of melanoma tumor antigen p97 (melanotransferrin) in multiple models in vitro and in vivo.
Richardson et al., Sydney, Australia. In Carcinogenesis, 2007
Novel molecular targets directly or indirectly regulated by MTf and the potential pathways involved in its function, including modulation of proliferation.
The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.
Richardson et al., Sydney, Australia. In Oncogene, 2007
this review discusses the studies that have demonstrated that melanotransferrin is not involved in iron metabolism, but plays a vital role in melanoma cell proliferation and tumorigenesis.
Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II.
Béliveau et al., Montréal, Canada. In Biol Chem, 2007
results suggest a Plg-mediated internalization mechanism for the clearance of sMTf via annexin II and LRP
Radiation carcinogenesis in mouse thymic lymphomas.
Niwa et al., Niigata, Japan. In Cancer Sci, 2006
One is the Bcl11b/Rit1 tumor suppressor gene and the other is Mtf-1 gene affecting tumor susceptibility.
The iron metabolism of neoplastic cells: alterations that facilitate proliferation?
Richardson et al., Sydney, Australia. In Crit Rev Oncol Hematol, 2002
These molecules include transferrin (Tf), the oestrogen-inducible transferrin receptor-like protein, transferrin receptor 2 (TfR2), melanotransferrin (MTf), ceruloplasmin, and ferritin.
The biology and tumour-related properties of monocyte tissue factor.
Cooper et al., Southampton, United Kingdom. In J Pathol, 2001
Several studies have shown that measurements of monocyte TF (mTF) may provide clinically significant information, particularly in patients with malignant and inflammatory diseases.
Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein.
Lindahl et al., Dallas, United States. In Cell, 1990
MTF, a murine minor histocompatibility antigen, is maternally inherited and thought to be encoded by a mitochondrial gene.
A new H-2-linked class I gene whose expression depends on a maternally inherited factor.
Chapman et al., In Nature, 1983
As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg.
Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.
Hellström et al., In Nature, 1983
p97 is a 97,000 molecular weight cell-surface glycoprotein, which is present in human melanomas but in only trace amounts in normal adult tissues.
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