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RAB8A, member RAS oncogene family

Mel, Rab8
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, tyrosinase
Papers using Mel antibodies
Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution
McGraw Elizabeth A et al., In BMC Evolutionary Biology, 2000
... Mel gene ids, ...
Papers on Mel
Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer.
Rimm et al., New Haven, United States. In Jama Oncol, Feb 2016
Human melanoma Mel 624 cells stably transfected with PD-L1 as well as Mel 624 parental cells, and human term placenta whole tissue sections were used as controls and for antibody validation.
Pro-proliferative function of mitochondrial sirtuin deacetylase SIRT3 in human melanoma.
Ahmad et al., Madison, United States. In J Invest Dermatol, Jan 2016
Conversely, forced exogenous overexpression of SIRT3 promoted increase in proliferative potential of Hs294T melanoma cells and normal immortalized Mel-ST melanocytes.
The 5'-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding.
Inga et al., Trento, Italy. In Oncotarget, Dec 2015
RNA immunoprecipitation performed in melanoma-derived SK-Mel-28 and in a patient-derived lymphoblastoid cell line indicated that YBX1 can bind the wild type p16INK4a mRNA increasing its translation efficiency, particularly during hypoxic stress.
Anti-inflammatory and cytotoxic activities of Bursera copallifera.
Rodríguez-López et al., Ecatepec, Mexico. In Pharmacogn Mag, Oct 2015
Methanol extract from the leaves (MeL) showed the highest anti-inflammatory activity (IC50 = 4.4 μg/mL), hydroalcoholic extract of leaves, and DMeL also reduce the enzyme activity, (IC50 = 6.5 μg/mL, IC50 = 5.7 μg/mL), respectively, from stems HAS exhibit activity at the evaluated concentrations (IC50 =6.4 μg/mL).
The DNA methylation inhibitor 5-azacytidine decreases melanin synthesis by inhibiting CREB phosphorylation.
Kim et al., In Pharmazie, Oct 2015
Here we examined the effects of a DNA methylation inhibitor, 5-azacytidine, on melanogenesis in Mel-Ab cells.
Review: Melatonin stimulates the synthesis and release of gonadotropin-inhibitory hormone in birds.
Tsutsui et al., Fukuoka, Japan. In Gen Comp Endocrinol, 2013
A melatonin receptor subtype, Mel(1c,) was expressed in GnIH-immunoreactive neurons, suggesting direct action of melatonin on GnIH neurons.
A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.
Guo et al., Philadelphia, United States. In J Biol Chem, 2012
Data suggest that the Rabin8-Rab8-Sec15 interaction may couple the activation of Rab8 to the recruitment of the Rab8 effector and is involved in the regulation of vesicular trafficking for primary cilium formation.
Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.
Stahl et al., Saint Louis, United States. In J Lipid Res, 2012
AS160 and Rab8a regulate membrane recruitment of CD36.
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
Jan et al., San Francisco, United States. In Neuron, 2012
This study demonistrated that Rabin8 regulates spine development.
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Gao et al., Newark, United States. In J Clin Invest, 2012
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.
Bretscher et al., Ithaca, United States. In Mol Biol Cell, 2012
EPI64 regulates membrane trafficking both by stabilizing Arf6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing Rab8a-GTP levels.
Mucosal strengthening activity of central and peripheral melatonin in the mechanism of gastric defense.
Brzozowski et al., Kraków, Poland. In J Physiol Pharmacol, 2009
Treatment with luzindole, an antagonist of Mel(2) receptors, or with L-NNA, the NO-synthase inhibitor, significantly attenuated melatonin- and L-tryptophan-induced protection and the acceleration of ulcer healing and the accompanying increase in the GBF and luminal content of NO.
The Rab8 GTPase regulates apical protein localization in intestinal cells.
Harada et al., Japan. In Nature, 2007
One microvillus inclusion disease patient who shows an identical phenotype to Rab8-deficient mice expresses a reduced amount of RAB8A
Epithelioid trophoblastic tumor: review of a rare neoplasm of the chorionic-type intermediate trophoblast.
Garcia et al., Seattle, United States. In Arch Pathol Lab Med, 2006
Inhibin-alpha is typically expressed, as well as focal, more variable expression of other trophoblastic markers including beta-human chorionic gonadotropin, human placental lactogen, placental alkaline phosphate, and Mel-CAM (CD148).
Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH): a review.
Wingfield et al., Hiroshima, Japan. In J Exp Zool A Comp Exp Biol, 2006
Interestingly, melatonin induced dose-dependently GnIH expression and melatonin receptor (Mel(1c)) was expressed in GnIH neurons.
Normal human melanocyte homeostasis as a paradigm for understanding melanoma.
Herlyn et al., Philadelphia, United States. In J Investig Dermatol Symp Proc, 2005
These melanoma cells escape from control by keratinocytes through five major mechanisms: (1) downregulation of receptors important for communication with keratinocytes such as E-cadherin, P-cadherin, and desmoglein, which is achieved through growth factors such as hepatocyte growth factor, platelet-derived growth factor, and endothelin-1 produced by fibroblasts or keratinocytes; (2) upregulation of receptors and signaling molecules important for melanoma cell-melanoma cell and melanoma cell-fibroblast interactions such as N-cadherin, Mel-CAM, and zonula occludens protein-1; (3) deregulation of morphogens such as Notch receptors and their ligands; (4) loss of anchorage to the basement membrane because of an altered expression of cell-matrix adhesion molecules; (5) increased elaboration of metal-loproteinases.
Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
Sarfarazi et al., Farmington, United States. In Science, 2002
The OPTN gene codes for a conserved 66-kilodalton protein of unknown function that has been implicated in the tumor necrosis factor-alpha signaling pathway and that interacts with diverse proteins including Huntingtin, Ras-associated protein RAB8, and transcription factor IIIA. Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role.
The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors.
Koseki et al., Chiba, Japan. In Immunity, 1997
mel-18 is a mammalian homolog of Drosophila melanogaster Polycomb group genes.
Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.
Seed et al., Boston, United States. In Nature, 1989
We report here that Leu-8 is the human homologue of the mouse Mel-14 homing receptor, a molecule that promotes the initial adhesion of blood-borne lymphocytes to the specialized post-capillary endothelium of peripheral lymph nodes.
Adhesion molecules controlling lymphocyte migration.
Stoolman, Ann Arbor, United States. In Cell, 1989
In contrast, the node-specific homing receptor Mel-14 consists of substructures homologous to calcium-dependent lectins, EGF, and complement binding proteins.
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