USP7 cooperates with SCML2 to regulate the activity of PRC1.
New York City, United States. In Mol Cell Biol, Apr 2015
First, we show that SCML2, a Polycomb group protein that associates with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing PCGF4/BMI1), modulates the localization of USP7 and bridges USP7 with PRC1.4,
Mel-18 interacts with RanGAP1 and inhibits its sumoylation.
Lexington, United States. In Biochem Biophys Res Commun, 2008
The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1.