Dysfunctional subcutaneous fat with reduced Dicer and brown adipose tissue gene expression in HIV-infected patients.
Bethesda, United States. In J Clin Endocrinol Metab, Feb 2016
Dicer expression was decreased in abdominal SC fat of HIV vs. non-HIV (4.88 [1.91, 11.93] vs.17.69 [10.72, 47.91], P=0.01), as were PGC1α, ZIC1, PRDM16, DIO2, and HSP60 (all P≤0.03).
Pre-Meiotic Anther Development: Cell Fate Specification and Differentiation.
Stanford, United States. In Annu Rev Plant Biol, Feb 2016
Here we describe the modern interpretation of pre-meiotic anther development, from the earliest cell specifications within the anther lobes through SPL/NZZ-, MSP1-, and MEL1-dependent pathways as well as the initial setup of the abaxial and adaxial axes and outgrowth of the anther lobes.
Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice.
Palma, Spain. In J Cell Physiol, Feb 2016
Primary white Rb(+/-) adipocytes displayed under basal conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b), but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, Shox2).
The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.
New York City, United States. In Trends Endocrinol Metab, Jan 2016
Studies have indicated crucial roles for PRDM16 in the determination and function of brown and beige fat as well as in hematopoiesis and cardiac development, highlighting the importance of PRDM16 in developmental processes in different tissues.
1p36 deletion syndrome: an update.
Houston, United States. In Appl Clin Genet, 2014
In particular, we highlight evidence implicating MMP23B, GABRD, SKI, PRDM16, KCNAB2, RERE, UBE4B, CASZ1, PDPN, SPEN, ECE1, HSPG2, and LUZP1 in various 1p36 deletion phenotypes.
Shades of brown: a model for thermogenic fat.
Berkeley, United States. In Front Endocrinol (lausanne), 2014
Here, we highlight recent advances in the understanding of brown and beige/brite adipocytes as well as transcriptional regulation for development and function of murine brown and beige/brite adipocytes focusing on EBF2, IRF4, and ZFP516, in addition to PRDM16 as a coregulator.