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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitogen-activated protein kinase kinase kinase 1

MEKK1, MEKK, MAPKKK, mitogen-activated protein kinase kinase kinase
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: JNK, MAPK, AP-1, p38, V1a
Papers using MEKK1 antibodies
RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis
Supplier
Malhotra Vivek et al., In The Journal of Cell Biology, 1997
... The anti–COOH-terminal MEK1 (C-18), RAF1 (C-12), and MEKK-1 (43-Y) were purchased from Santa Cruz Biotechnology.
Papers on MEKK1
A Mutant of the Bck1 Homolog from Cryphonectria parasitica Resulted in Sectorization with an Impaired Pathogenicity.
New
Park et al., Seoul, South Korea. In Mol Plant Microbe Interact, Feb 2016
UNASSIGNED: CpBck1, an ortholog of the cell wall integrity MAPKKK of Saccharomyces cerevisiae, was cloned and characterized from the chestnut blight fungus Cryphonectria parasitica.
Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.
New
Borck et al., Berlin, Germany. In Genome Res, Feb 2016
ZAK is a member of the MAPKKK family with no known role in limb development.
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
New
Zhu et al., Lanzhou, China. In Mol Med Report, Feb 2016
Therefore, netrin‑1 prevented cardiac hypertrophy and heart failure through the negative regulation of the MEKK1-dependent MEK‑ERK1/2 and JNK1/2 signaling pathways.
Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11).
New
Donahue et al., Baltimore, United States. In Oncotarget, Jan 2016
MiR-199a-5p is predicted to bind mitogen-activated protein kinase kinase kinase 11 (MAP3K11) mRNA with high affinity.
MAP3K1-targeting therapeutic artificial miRNA suppresses the growth and invasion of breast cancer in vivo and in vitro.
New
Shao et al., Nantong, China. In Springerplus, Dec 2015
MEK kinase 1 (MEKK1) is expressed by mitogen-activated kinase kinase kinase 1 (MAP3K1), an important kinase that links Ras activation to MAPK signaling.
The Accomplices of NF-κB Lead to Radioresistance.
Review
Han et al., Beijing, China. In Curr Protein Pept Sci, 2014
The primary purpose of this review is to introduce the studies of the signaling mechanisms of IR in NF-κB activation, such as ROS/NF-κB, ATM or DNA-PK/MAPKK/ p90rsk, PI3K/AKT/IKK and k-ras/c-raf/ MEKK/ NF-κB pathways.
[Inhibition of stress-responsive signaling pathway prevents neural cell death following optic nerve injury].
Review
Katome, In Nihon Ganka Gakkai Zasshi, 2014
Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein kinase kinase kinase (MAPKKK) and plays an important role in stress-induced RGC apoptosis.
MEK1/2 inhibitors in the treatment of gynecologic malignancies.
Review
Farley et al., Houston, United States. In Gynecol Oncol, 2014
While several three-tiered MAPK cascades have been elucidated in mammals, the prototypical pathway involves a network of proteins and kinases including the Rat sarcoma protein (Ras), mitogen-activated protein kinase kinase kinase (Raf or MAP3K), mitogen-activated protein kinase kinase (MEK or MAP2K), and extracellular signal regulated protein kinase (ERK or MAPK).
Glutamate signalling in roots.
Review
Forde, Lancaster, United Kingdom. In J Exp Bot, 2014
The recent finding that the MEKK1 gene is a positive regulator of glutamate sensitivity at the root tip has provided genetic evidence for the existence in plants of a glutamate signalling pathway analogous to those found in animals.
Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.
Review
Kanthasamy et al., Maywood, United States. In Genes Cancer, 2013
Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways.
The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation.
GeneRIF
Cuevas et al., Chicago, United States. In Biochem J, 2012
Proximal to the RING domain is a SWIM (SWI2/SNF2 and MuDR) domain. The MEKK1 SWIM domain, but not the RING domain, directly associates with the c-Jun DNA-binding domain, and the SWIM domain is required for MEKK1-dependent c-Jun ubiquitylation.
Association study of 45 candidate genes in nicotine dependence in Han Chinese.
GeneRIF
Ma et al., Chengdu, China. In Addict Behav, 2012
For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism.
Multilocus analysis of candidate genes involved in neurogenic inflammation in pediatric asthma and related phenotypes: a case-control study.
GeneRIF
Dmitrzak-Węglarz et al., Poznań, Poland. In J Asthma, 2012
We also observed that four Single Nucleotide Polymorphisms (SNPs) were associated with severe asthma
The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis.
GeneRIF
Zhang et al., Beijing, China. In Plant Cell, 2012
Data suggest that the MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates MEKK2 and activation of MEKK2 triggers SUMM2-mediated immune responses.
CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model.
Impact
GeneRIF
Ryoo et al., New York City, United States. In Nat Cell Biol, 2012
The CDK5 phosphorylates MEKK1, and together, they activate the JNK pathway for apoptosis.
Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway.
Impact
Wang et al., Stanford, United States. In Nature, 2012
Here we demonstrate in Arabidopsis that brassinosteroid regulates stomatal development by activating the MAPK kinase kinase (MAPKKK) YDA (also known as YODA).
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
Impact
Takekawa et al., Tokyo, Japan. In Nat Cell Biol, 2011
Oncogenic Ras inhibits MEK SUMOylation by impairing the function of the MEKK1 MAPKKK as a SUMO-E3 ligase specific for MEK.
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
Impact
Jin et al., San Diego, United States. In Cell, 2009
The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth in C. elegans and other animals.
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation.
Impact
Czech et al., Worcester, United States. In Nature, 2009
Screening with GeRPs for inflammation genes revealed that the mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) is a previously unknown mediator of cytokine expression.
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