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Meis homeobox 2

Meis2, Mrg1
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Meis1, ACID, CITED1, p300
Papers on Meis2
Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.
New
Zhou et al., Nijmegen, Netherlands. In Hum Genet, Jan 2016
Our analyses of these overlapping CNVs identified two genes known to be causative for human OFCs, SATB2 and MEIS2, and 12 genes (DGCR6, FGF2, FRZB, LETM1, MAPK3, SPRY1, THBS1, TSHZ1, TTC28, TULP4, WHSC1, WHSC2) that are associated with OFC or orofacial development.
MEIS2 involvement in cardiac development, cleft palate, and intellectual disability.
New
Devriendt et al., Leuven, Belgium. In Am J Med Genet A, May 2015
MEIS2 has been associated with cleft palate and cardiac septal defects as well as varying degrees of intellectual disability.
Depletion of MEIS2 inhibits osteogenic differentiation potential of human dental stem cells.
Wang et al., Beijing, China. In Int J Clin Exp Med, 2014
Here, we investigate regulatory function of homeobox gene MEIS2 in the osteogenic differentiation potential of MSCs using stem cells from apical papilla (SCAPs) and dental pulp stem cells (DPSCs) by loss-of-function experiments.
12p microRNA expression in fibroblast cell lines from probands with Pallister-Killian syndrome.
Krantz et al., Philadelphia, United States. In Chromosome Res, 2014
In particular, expression levels of MEIS2 and UQCRB were significantly decreased in Pallister-Killian syndrome samples, and an inverse linear correlation was seen between the level of miR-1244 and MEIS2 and UQCRB expression levels.
Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.
Tryggvason et al., Uppsala, Sweden. In J Am Soc Nephrol, 2014
Among these candidates, motif-driven podocyte enhancer activity of CCNC and MEIS2 was functionally analyzed in vivo.
A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies.
Kalionis et al., Jinan, China. In Reprod Sci, 2014
Immunohistochemistry of candidate genes in first trimester placental villous stromal tissue revealed homeobox genes Meis1, myeloid ectropic viral integration site 1 homolog 2 (MEIS2), H2.0-like Drosophila (HLX), transforming growth factor β-induced factor (TGIF), and distal-less homeobox 5 (DLX5) were expressed in the vascular niche where CMSCs have been shown to reside.
Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression.
Dong et al., Shanghai, China. In Plos Genet, 2014
Here, we show that the Arabidopsis Morf Related Gene (MRG) group proteins MRG1 and MRG2 act as H3K4me3/H3K36me3 readers and physically interact with CO to activate FT expression.
Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development.
Review
Srivastava et al., Baltimore, United States. In Drug Dev Res, 2014
The OCD susceptibility genes DLGAP1, RYR3, PBX1-MEIS2, LMX1A and candidate genes BDNF and GRIN2B are components of the neuronal growth, differentiation and neurogenesis pathways BDNF-mTOR.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Impact
Thomä et al., Basel, Switzerland. In Nature, 2014
Using an unbiased screen, we identified the homeobox transcription factor MEIS2 as an endogenous substrate of CRL4(CRBN).
Haploinsufficiency of MEIS2 is associated with orofacial clefting and learning disability.
Houge et al., Bergen, Norway. In Am J Med Genet A, 2014
MEIS2 is a homeodomain-containing transcription factor of the TALE superfamily that has been proven important for development.
Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.
Koseki et al., Yokohama, Japan. In Dev Cell, 2014
Here, we used the mouse Meis2 gene as a model to identify a role of a tissue-specific enhancer in removing PcG from the promoter.
Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
Ito et al., Singapore, Singapore. In Nucleic Acids Res, 2013
Here, we demonstrate that two closely related Arabidopsis homologues (MRG1 and MRG2) are localised to the euchromatin and redundantly ensure the increased transcriptional levels of two flowering time genes with opposing functions, FLOWERING LOCUS C and FLOWERING LOCUS T (FT).
MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression.
Ding et al., Yichang, China. In Cell Death Dis, 2013
MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer.
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.
Impact
Murry et al., Seattle, United States. In Cell, 2012
We used this temporal chromatin signature to identify regulators of cardiac development, including the homeobox gene MEIS2.
Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.
GeneRIF
Wotton et al., Charlottesville, United States. In Mol Cell Biol, 2011
Klf4 recruits a complex of Meis and Pbx proteins to DNA, resulting in Meis2 transcriptional activation domain-dependent activation of a subset of Klf4 target genes.
MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.
GeneRIF
Aizawa et al., Kōbe, Japan. In J Neurosci, 2011
Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression.
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
GeneRIF
van den Oord et al., Richmond, United States. In Mol Psychiatry, 2011
The Single Nucleotide Polymorphism in Meis homeobox 2 (MEIS2) mediated the effects of risperidone on hip circumference (q=0.004).
Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain.
GeneRIF
Møller et al., Copenhagen, Denmark. In Dev Neurosci, 2010
Data demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are expressed during early fetal brain development in humans.
An autoinhibitory effect of the homothorax domain of Meis2.
GeneRIF
Wotton et al., Charlottesville, United States. In Febs J, 2010
This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
The role of the MEIS homeobox genes in neuroblastoma.
Review
Versteeg et al., Amsterdam, Netherlands. In Cancer Lett, 2003
We now demonstrate high-level expression of the MEIS1 and MEIS2 genes, as well as efficient expression of most other TALE family member genes in a panel of neuroblastoma cell lines.
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